Structure of PDB 6yan Chain f Binding Site BS01

Receptor Information

>6yan Chain f (length=71) Species: 9986 (Oryctolagus cuniculus)

KKSYTTPKKNKHKRKKVKLAVLKYYKVDENGKISRLRRECPSDECGAGVF
MASHFDRHYCGKCCLTYCFNK

Ligand information

>6yan Chain 2 (length=1744)

uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgccuacuuggauaacugugguaauu
cuagagcuaauacaugccgacggcgcugacucccuuugugugggaugcgu
gcauuuaucagaucaaaaccaacccggucggcggcuuuggugacucuaga
uaaccucgggccgaucgcagcccuccguggcggcgacgacccauucgaac
gucugcccuaucaacuuucgaugguagucgccgugccuaccauggugacc
acgggugacggggaaucaggguucgauuccggagagggagccugagaaac
ggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccga
cccggggagguagugacgaaaaauaacaauacaggacucuuucgaggccc
uguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggag
ggcaagucuggucgcagcagccgcgguaauuccagcuccaauagcguaua
uuaaaguugcugcaguuaaaaagcucguaguuggaucuuguggaggguuc
cccgccccuugccucucggcgccggcccgaagcguuuacuuugaaaaaau
uagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaaua
auggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccau
gauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaa
uucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaaug
uuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauacc
gucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuau
ucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccg
gggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggca
ccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccuc
acccggcccggacacggacaggauugacagauugauagcucuuucucgau
ucugugggugguggugcauggccguucuuaguugguggagcgauuugucu
gguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcga
cccccgagcggucggcgucccccaacuucuuagagggacaaguggcguuc
agccacccgagauugagcaauaacaggucugugaugcccuuagaugucgg
ggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgcc
ggcaggcgcggguaacccguugaaccccauucgugauggggaucggggau
ugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaag
cuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacua
ccgauuggaugguuuagugaggcccucggaucggcccgccggggugcccu
ggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaa
gucguaacaagguuuccguaggugaaccugcggaaggaucauua

...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.
[[[..<<....<<....<<..........>>...>>.>>......{{...
.....[[[......{{....[[[.........<<.....<<.<<<.....
>>>.>>......>>........<<<<...<<.<......>.>>...>>>>
[[..(((((.....<<<<<<<<<<<<.....>>>....<......>..))
)))......]]...<<<<.<<<......>>>.>>>>....]]]...}}..
..]]].<<<....<<<....<<<<<<<.........>>>>>>>>>>....
..>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<.........
.>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<<.
..>>>>..>>>......}}.......<<<<<<<<<.<<<....>>>.>>.
>>>>.>>>......<<..<...........>..>>.........<<<<<(
(....<.<<<<.....<<..))>>.......>>>>>>>>>>..)))))).
]]]............{{.......{{...[[[.[[....<<<<.<<...>
>>>>>........<......<<..>>....>....<<<<<<.<.......
<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>
>.......[[....(((((((.....>>>>>>>>>.)))))))...]]..
..]]....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......
>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>
>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>
>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<
....>>>>>>>>>>>.>..>>>...<<..}}>>...>>.....>>>....
.<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<
..<<..<<<<<..<<<.<<<<<<......<<........>>.........
.<<<<<......<<<<<<.......<<.<<<........>>>.>>.....
>>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<
<<......>>>...>>.>>>....<<<...<...<<<<..<<<<....<<
<.<.<<<....>>>>.>>>....>>>>..>>>>..>.....<<<<<....
.>>>>>........>>>....>>>.>>>...>.>>>>>>>......>>>>
>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<
....>>>>.>>>....>.........>>>.>>............<<<<<.
.........>>>>>...........>>>>>.....<<<<<<<<.......
>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.
<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<..>>>>
>>>>....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...
>.>>...>.....<<<<<<<<<....>>>>>>>>>.........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6yan Structural Insights into the Mammalian Late-Stage Initiation Complexes.
• Resolution: 3.48 Å
• Binding residue (original residue number in PDB): K82 K83 S84 Y85 P88 K90 N91 K92 H93 K94 R95 K97 K99 L100 A101 V102 L103 K104 Y105 R118 V130 F131 A133 H135 R138 Y140 G142 C145
• Binding residue (residue number reindexed from 1): K1 K2 S3 Y4 P7 K9 N10 K11 H12 K13 R14 K16 K18 L19 A20 V21 L22 K23 Y24 R37 V49 F50 A52 H54 R57 Y59 G61 C64

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome

External links

• PDB: RCSB:6yan, PDBe:6yan, PDBj:6yan
• PDBsum: 6yan
• PubMed: 32268096
• UniProt: G1SK22|RS27A_RABIT Ubiquitin-ribosomal protein eS31 fusion protein (Gene Name=RPS27A)