Structure of PDB 6gsm Chain f Binding Site BS01

Receptor Information

>6gsm Chain f (length=69) Species: 284590 (Kluyveromyces lactis NRRL Y-1140)

KKVYTTPKKIRHKHKKVKLAVLNYYKVDDEGKVAKLRKECPNCGPGIFLA
NHGDRFYCGKCHSTFATQK

Ligand information

>6gsm Chain 2 (length=1798)

uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcuca
uuaaaucaguuaucguuuauuugauaguuccuuuacuacauggauaucug
ugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagag
auguauuuauuagauaaaaaaucaaugucuucggacuccuugaugauuca
uaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaa
uuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuuc
aacggguaacggggaauaaggguucgauuccggagagggagccugagaaa
cggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccua
auucagggagguagugacaauaaauaacgauacagggcccauucgggucu
uguaauuggaaugaguacaauguaaauaccuuaacgaggaacaacuggag
ggcaagucuggugccagcagccgcgguaauuccagcuccaguagcguaua
uuaaaguuguugcaguuaaaaagcucguaguugaacuuugggucugguug
uccgguccgacuuuaugucgcgcacugguuuucaaccggaucuuuccuuc
uggcuaaccuguacuccuugugggugcaggcgaaccaggacuuuuacuuu
gaaaaaauuagaguguucaaagcaggcgaaagcucgaauauauuagcaug
gaauaauggaauaggacguuugguucuauuuuguugguuucuaggaccau
cguaaugauuaauagggacggucgggggcaucaguauucaauugucagag
gugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugcca
aggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugauca
gauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugg
uguuuuucuuaugacccacucggcaccuuacgagaaaucaaagucuuugg
guucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacgga
agggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggg
aaacucaccagguccagacacaauaaggauugacagauugagagcucuuu
cuugauuuugugggugguggugcauggccguucuuaguugguggagugau
uugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaggg
uugcuggcacuugccgguugacucuucuuagagggacuaucgguuucaag
ccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucu
gggccgcacgcgcgcuacacugacggagccagcgaguacaaccuuggccg
agaggucuggguaaucuugugaaacuccgucgugcuggggauagagcauu
guaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagc
uugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguac
cgauugaauggcuuagugaggccucaggauuugcuuagagaagggggcaa
cuccaucucagagcgaagaaucuggucaaacuuggucauuuagaggaacu
aaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua

...<<<<<...[[[[>>>>>[[[[.((((((................[[[
.[[[...<....<<....<<..........>>...>>.>.......{{..
......[[[......{{....[[[{...............<<.....<<.
.<.......>..>>......>>........<<<<<............>>>
>>{..[[.((((......<<<<<<<<.<......>...............
))))]].....}...<<<<..<<<.....>>>.>>>>..}.]]]...}}.
...]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>...
...>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<........
..>>>.>>.<.<......>.>...]]]]]].........<<<....<<<.
....>>>..>>>................<..<<<<<.<.......>..>>
>>>...>.......<<..<...........>.>.>.........<<<<<(
(......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]
]]].........[[[{{.......{{...[[[.{{.....<<<<<<<<<<
.<<<<<.<<<.......>>>...>>>>>....>>>>>>>>>>.....<<<
<<<......<.................>......>>>>>>...<<<<<.<
<......<<<...<.......>..<<<....>>>....>>.>....>>.>
>..>>>.........[[[..(((((((.....>>>>>>>>..))))))).
]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<.
.......>>......>.>>>>>>..>>.......<<....>>...>>>>.
..>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<....
.....>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<
.<<.<.......>>>>>>>>>>>..>>>...<<..}}>>...>>.....>
>>.]]].<<<......<.<......>.>....>>>..]]]]..<<<<<.<
<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>...
.......<<<<<.<....<<<<<........<<..<<........>>..>
>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<......
>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<....<<
<<<.<<<<....>>>>.>.>>>>....>>>>.>>....<<<<<<.....>
>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>
>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<<..<<<.
...>>>..>>>....>>.......>>>>>>>......<....<<<<<<..
........>>>>>>....>.....>>>>>>....<<<<<<<<.......>
>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<
<....<<<<<<<<.<<<..<<<<......<<<<<<.<<............
......>>...>>>>>>......>>>>..>>>.>>>>>>>>...>>.>>>
>...>.>>...>.....<<<<<<<<<....>>>>>>>>>.........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6gsm Large-scale movement of eIF3 domains during translation initiation modulate start codon selection.
• Resolution: 5.15 Å
• Binding residue (original residue number in PDB): P88 K90 I91 R92 H93 H95 K97 V98 V102 N104 R118 F129 L130 A131 H133 Y138 H143
• Binding residue (residue number reindexed from 1): P7 K9 I10 R11 H12 H14 K16 V17 V21 N23 R37 F48 L49 A50 H52 Y57 H62

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome

External links

• PDB: RCSB:6gsm, PDBe:6gsm, PDBj:6gsm
• PDBsum: 6gsm
• PubMed: 34648019
• UniProt: P69061|RS27A_KLULA Ubiquitin-ribosomal protein eS31 fusion protein (Gene Name=ubi3)