Structure of PDB 4kzy Chain f Binding Site BS01

Receptor Information

>4kzy Chain f (length=71) Species: 9986 (Oryctolagus cuniculus)

KKSYTTPKKNKHKRKKVKLAVLKYYKVDENGKISRLRRECPSDECGAGVF
MASHFDRHYCGKCCLTYCFNK

Ligand information

>4kzy Chain i (length=1840)

uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucgcuccucuccuacuuggauaa
cugugguaauucuagagcuaauacaugccgacggcgcugacucccuuugu
gugggaugcgugcauuuaucagaucaaaaccaacccggucagccuccccg
ccggccggggggguggggcggcggcuuuggugacucuagauaaccucggg
ccgaucgcagcccuccguggcggcgacgacccauucgaacgucugcccua
ucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacg
gggaaucaggguucgauuccggagagggagccugagaaacggcuaccaca
uccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagg
uagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauugga
augaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucug
gucgcagcagccgcgguaauuccagcuccaauagcguauauuaaaguugc
ugcaguuaaaaagcucguaguuggaucuuggagggugcguagcgggccac
cgcccguccccgcccugccucucggcgcccccucgaugcucuuagcugag
ugucccgcggggcccgaagcguuuacuuugaaaaaauuagaguguucaaa
gcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggacc
gcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggac
ggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggc
gcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaauca
agaacgaaagucggagguucgaagacgaucagauaccgucguaguuccga
ccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgc
cgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguauggu
ugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggagugg
agccugcggcuuaauuugacucaacacgggaaaccucacccggcccggac
acggacaggauugacagauugauagcucuuucucgauucuguggguggug
gugcauggccguucuuaguugguggagcgauuugucugguuaauuccgau
aacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcgguc
ggcgucccccaacuucuuagagggacaaguggcguucagccacccgagau
ugagcaauaacaggucugugaugcccuuagaugucggggcugcacgcgcg
cuacacugacuggcucagcgugugccuacccuacgccggcaggcgcgggu
aacccguugaaccccauucgugauggggaucggggauugcaauuauuccc
caugaacgaggaauucccaguaagugcgggucauaagcuugcguugauua
agucccugcccuuuguacacaccgcccgucgcuacuaccgauuggauggu
uuagugaggcccucggaucggcccgccggggucggcccacggcccuggcg
gagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucg
uaacaagguuuccguaggugaaccugcggaaggaucauua

...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.
[[[..<<....<<....<<..........>>...>>.>>......{{...
.....[[[......{{....[[[....................<<.....
<<.<<<.....>>>.>>......>>.......<..<<...<<.<......
>.>>...>>.>[[..(((((.....<<<<<<<<<<<<.<...<.<<<...
.......>..>.>.>.....>>>>..............)))))......]
]...<<<<.<<<......>>>.>>>>....]]]...}}....]]].<<<.
...<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<
<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.
<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>
>......}}.......<<<<<<<<<.<<<....>>>.>.>>>>>.>>>..
....<<..<...........>..>>.........<<<<<((......<<<
<.....<<..))>>.......>>>>.>>>>>..)))))).]]].......
.....{{.......{{...[[[.[[....<..<<<...<..<........
>..>...>>>..>...<<.<......<<<<<...<<<<<<<......>>>
>>>>....>>>>>...>.>>..<<<<<..<.......<<...<.......
>.<<<<.......>>>>...>>......>..>>..>>>.......[[...
.(((((((.....>>>>>>>>>.)))))))...]]....]]....<<<<<
<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>
>>>.>.>>.......<<....>>...>>>>..>..>>>.>>>...]]]..
.}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>
>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>
>>.>..>>>...<<..}}>>...>>.....>>>.....<<<......<<<
......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<..<<<<<..
<<<.<<<<<<......<<........>>..........<<<<<......<
<<<<<.......<<.<<<........>>>.>>.....>>>>>>.<.<<.<
<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>..
.>>.>>>....<<<...<...<<<<..<<<<....<<<..<<<<....>>
>>.>>>....>>>>..>>>>..>.....<<<<<.....>>>>>.......
.>>>....>>>.>>>...>.>>>>>>>>.....>>>>>...>>.>>>>.>
>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>.
...>.........>>>.>>............<<<<<..........>>>>
>...........>>>>>.....<<<<<<<<.......>>>>>>>>.....
.>>...>>>>>>>>>>.>>.......<<.<..<<<<.<<....<<<<<<<
<.<<<..<<<<.<<...<<<<<.<<<<<<<<<<<.....>>>>>>>>>>.
>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>
.........<<<<<<<<<....>>>>>>>>>.........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4kzy The initiation of mammalian protein synthesis and mRNA scanning mechanism.
• Resolution: 7.01 Å
• Binding residue (original residue number in PDB): K82 K83 Y85 T87 K92 K94 R95 K97 L100 A101 R118 A133 H135 R138 Y140 G142 K143 C145 L146
• Binding residue (residue number reindexed from 1): K1 K2 Y4 T6 K11 K13 R14 K16 L19 A20 R37 A52 H54 R57 Y59 G61 K62 C64 L65

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0031386 protein tag activity
• GO:0031625 ubiquitin protein ligase binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006412 translation
• GO:0016567 protein ubiquitination
• GO:0019941 modification-dependent protein catabolic process

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022626 cytosolic ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:4kzy, PDBe:4kzy, PDBj:4kzy
• PDBsum: 4kzy
• PubMed: 23873042
• UniProt: G1SK22|RS27A_RABIT Ubiquitin-ribosomal protein eS31 fusion protein (Gene Name=RPS27A)