Structure of PDB 8p2h Chain e Binding Site BS01

Receptor Information
>8p2h Chain e (length=199) Species: 93061 (Staphylococcus aureus subsp. aureus NCTC 8325) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ARFRGSNWKKSRRLGISLSGTGKELEKRPYAPGQHGPNQRKKLSEYGLQL
REKQKLRYLYGMTERQFRNTFDIAGKKFGVHGENFMILLASRLDAVVYSL
GLARTRRQARQLVNHGHILVDGKRVDIPSYSVKPGQTISVREKSQKLNII
VESVEINNFVPEYLNFDADSLTGTFVRLPERSELPAEINEQLIVEYYSR
Ligand information
>8p2h Chain a (length=1534) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auggagaguuugauccuggcucaggaugaacgcuggcggcgugccuaaua
caugcaagucgagcgaacggacgagaagcuugcuucucugauguuagcgg
cggacgggugaguaacacguggauaaccuaccuauaagacugggauaacu
ucgggaaaccggagcuaauaccggauaauauuuugaaccgcaugguucaa
aagugaaagacggucuugcugucacuuauagauggauccgcgcugcauua
gcuaguugguaagguaacggcuuaccaaggcaacgaugcauagccgaccu
gagagggugaucggccacacuggaacugagacacgguccagacuccuacg
ggaggcagcaguagggaaucuuccgcaaugggcgaaagccugacggagca
acgccgcgugagugaugaaggucuucggaucguaaaacucuguuauuagg
gaagaacauauguguaaguaacugugcacaucuugacgguaccuaaucag
aaagccacggcuaacuacgugccagcagccgcgguaauacguagguggca
agcguuauccggaauuauugggcguaaagcgcgcguaggcgguuuuuuaa
gucugaugugaaagcccacggcucaaccguggagggucauuggaaacugg
aaaacuugagugcagaagaggaaaguggaauuccauguguagcggugaaa
ugcgcagagauauggaggaacaccaguggcgaaggcgacuuucuggucug
uaacugacgcugaugugcgaaagcguggggaucaaacaggauuagauacc
cugguaguccacgccguaaacgaugagugcuaaguguuagggggccccuu
agugcugcagcuaacgcauuaagcacuccgccuggggaguacgaccgcaa
gguugaaacucaaaggaauugacggggacccgcacaagcgguggagcaug
ugguuuaauucgaagcaacgcgaagaaccuuaccaaaucuugacauccuu
ugacaacucuagagauagagccuuccggacaaagugacagguggugcaug
guugucgucagcucgugucgugagauguuggguuaagucccgcaacgagc
gcaacccuuaagcuuaguugccaucauuaaguugggcacucuaaguugac
ugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugcc
ccuuaugauuugggcuacacacgugcuacaauggacaauacaaagggcag
cgaaaccgcgaggucaagcaaaucccauaaaguuguucucaguucggauu
guagucugcaacucgacuacaugaagcuggaaucgcuaguaaucguagau
cagcaugcuacggugaauacguucccgggucuuguacacaccgcccguca
caccacgagaguuuguaacacccgaagccgguggaguaaccuuuuaggag
cuagccgucgaaggugggacaaaugauuggggugaagucguaacaaggua
gccguaucggaaggugcggcuggaucaccuccuu
.....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<
<.<<<..<<<..<<.<<<<...<<<..........>>>...>>>>.>>>>
>......<<........<<<<<<<..<<...<<<<<<<.<<<<.....<<
<<<<....>>>>>>......>>>>......<<<<<<<<<<..>>>>>>>>
>>......<<<<<<...>>>>>>.>>>>>>>..>>>>>>>>>.<<<....
<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<
....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....
>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>
.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<<<<<<<
.......<.<<<<<<<........>>>>>>>.>........>>>>>>...
>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>.
.>>>>>>>>>..........<<<((.....<<<<<..<<<.<<<<<<<.<
<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>
>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......
>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>
>.>>>...>>>..>>>>>....<<<<<<<...<...<<<<.........>
>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<..>>>>>
>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....
>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<
<<<<......<<........>>..........<<<<<<<......<<<<<
<......<<<<....>>>>...........>>>>.>>.<<<.<<<..<<<
<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>
.....<<<<.<<<<<<<..<<..<<<......>>>>>...>>>>>>>...
..<<<<<.....>>>>>........>>>>.........>>>...>>>>>>
>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<
<...<<<....>>>...>>....>>>.....>>>>>>>......<....<
<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..
.......>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.
<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<<...>>>.>
>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<
<<<<<<<<....>>>>>>>>>.............
Receptor-Ligand Complex Structure
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PDB8p2h Staphylococcus aureus 70S ribosome with elongation factor G locked with fusidic acid with a tRNA in pe/E chimeric hybrid state
Resolution2.49 Å
Binding residue
(original residue number in PDB)
R3 R5 S7 W9 K10 R13 R14 K28 R29 Y31 P33 G34 Q35 H36 Y47 K54 Q55 T64 E65 R66 Q67 N70 K77 R105 T106 R108 Q109 Q112 N115 H116 H118 D127 I128 S130 L148 E196 R200
Binding residue
(residue number reindexed from 1)
R2 R4 S6 W8 K9 R12 R13 K27 R28 Y30 P32 G33 Q34 H35 Y46 K53 Q54 T63 E64 R65 Q66 N69 K76 R104 T105 R107 Q108 Q111 N114 H115 H117 D126 I127 S129 L147 E195 R199
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
GO:0042274 ribosomal small subunit biogenesis
Cellular Component
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8p2h, PDBe:8p2h, PDBj:8p2h
PDBsum8p2h
PubMed38902339
UniProtQ2FXK6|RS4_STAA8 Small ribosomal subunit protein uS4 (Gene Name=rpsD)

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