Structure of PDB 8etg Chain e Binding Site BS01

Receptor Information
>8etg Chain e (length=117) Species: 4896 (Schizosaccharomyces pombe) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VNIIKKRTKPFKRHQSDRFKRVGESWRKPRGIDSCVRRRFRGTISMPKIG
YGNNKKTRYCMPNGLKAFLVRNVSDVELLLMHNKTYAAEIAGNVSARKRV
EIVEKARALGVKVTNAG
Ligand information
>8etg Chain 1 (length=2018) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uugaccucaaaucagguaggacuacgcgcugaaaauaagcgcaggaaaag
aaaauaaccaugauucccucaguaacgugaagcgggaaaagcucaaauuu
gaaaucuggcaacauuucuuuuguuguccgaguuguaauuucaagaagcu
gcuuugaguguagacgaucggucuaaguuccuuggaacaggacgucagag
agggugagaaccccgucuuuggucgauuggauaugccauauaaagcgcuu
ucgaagagucgaguugugcagcucuaaauggguggucaucuaaagcuaaa
uauuggcgagagaccgauagcgaacaaguagagugaucgaaagaugaaaa
gaacuuugaaaagagaguuaaauaguacgugaaauugcugaaagggaagc
auuggaaaucaggucagcaucaguuuucgggggcggaaaaagaauaaggg
aagguggcuguuuauagcccuuguuguaauacguccacuggggacugagg
acugcggcuucgugccaaggaugcugacauaaugguuuucaauggcccgu
ccacggaccaaggagucuagcaucuaugcgaguguuugggugaugaaaac
ccauccgcgaaaugaaagugaggugggaacgcccuuguggcgugcaccau
cgaccguaagagcauagcuguugggacccgaaagauggugaaaccaucua
guagcugguuccugccgaaguuucccucaggauagcagaaacucagauca
guuuuaugaguauguaaaaugagaguuucuagugggccauuuuugguaag
cagaacuggcgaugcgggaugaaccgaacgugagguuaaggugccggaau
guacgcucaucagaagaaaagguguuaguucaucuagacagcaggacggu
ggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccg
aaugaacuagcccugaaaauggauggcgcuuaagcguacuacccauaccu
caccgucuggguuaggaagcucagacgaguaggcaggcguggagguuugu
gacgaagccuugggcgugagccugggucgaacagccucuagugcagaucu
ugguggaaguagcuucaaaugagaacuuugaagacugaaguggggaaagg
uuccaugugaacagcaguuggacauggguuagucgauccuaagagauagg
gaagcuccguaugaaaggcacgauuuuucgugccuaucgagggaauccgg
uuaauauuccggaaccagaagguggaauacggcaacguaaaugaaguugg
agacgucggcgggagcccugggaagaguucucuuuucuuuuuaacaaacc
auuacccugacuaggguaugguguuuggaagaguucagcgccucaugcug
aauccggugcgcucucgacggccaaaauccaacggaaguuuucacaucug
gucguacucuccaaggugaacagccucuaguugauagaacaauguagaua
agggaagaaugggcccacugucccuaucuacuaucuagcgaaaccacagc
cuggggggccaggcaaaaucagcggcuuguggcagccaagcgcgacguug
cucggcucuuccuaucauaccgaagcagaauucgguaagcguuggaccca
cuaauagggaacgugagcuggccuacugaugaagugucgucgcaauggua
auucaacuuaguacgagaggaaccguugauucagaucauugguauuugcg
gcugccugacaaggcaaugccgcggagcuaucaucugcuggauaacggcu
gaacgccucuaagccagaauccgugccagaaagcgacgauuuguauaaaa
auagagguaggcuacucuccuguaucguagaagaugggcgaugguugaug
aaacggaaguguuuuauugacuuguccaugaaauuccagaauccauugca
uacgacuuuaauguggaacgggguauuguaagcagcugcugagauuaagc
cuuuguucccaagauuug
........................<<<<<<.......>>>>>.>......
...<<....>>..<<<<<......<..>.....>>>>>..<<<..<<...
....<<.<<<<<<<.......>>>>>>>.>>.......>>....<<<<<.
<<<<<..<<<<<..<<<<<<<<<.....<<<<......>>>>.((.....
.<<<.....))>>>......>>>>>>>>>..>>>>>.....>>>>>>>>.
>>........<<<<<<..>>>>>>.....<<<<<..>>>>>..>>>....
..............................<<....>>............
...<<<<....>>>>..................................<
<<<<<<<<<<<.<<<<<<<.<<<<<<<<<<<<<<<........<<<<<<<
.................>>>>>>>.......>>>>>.>>>>>>>>>>...
.....<<<.....>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<
..>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.......>>
>>...>>>...<<....>>..<<<<<..<<<<<.....>>>>>...>>>>
>.<<.>>....>>>>>>.>>>>>>..<<.<...<<<<<<...>>>>>>..
....>.>>..<<<<<<....<..<<....>>..><<<<<<<<<<...<<<
.<<<<<<<....>>>>>>>>>>>>>>>>>>.>>..<<<<.<<<<<.....
>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....
<<<<<<.....<<......<<<.<<<<<<<<<<.......<<<<<.<<..
..<<.........>>....>>.........<<......>>...>>>>>..
.>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>...>>>>
>>><<<<<<<<<......>>>>>>>>>....>>>>>><.<<<<<<<<.<<
......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>
>>>><<.....<<<<<<<<.......>>>>>><<<<.....<<<...<<.
..<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<
<....>>>........<<<<<<......>>>>>>..>>..>>...<<<<<
........>>>>>))<<<<..<<<<...<<<....>>>.......<<<<<
<...<<<<.<<<<<<<.<<<<<<<<<<.......>>>>>>....<<<<..
..<<<<<<<..>>>>>>>.....>>>>.....<<<<<<<<.....>>>>>
>>>>>>>...>>>>>>>.>>>>.....>>>>>>......>..>>>.>>>>
>>>>..>>.>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<
.<<.......<<..>>.....>>.>>>>>>>..>>>>>>....>>....<
<<<<....>>>>>....<<<<<.<.......<<<<<...<..>...>>>>
>.<<<<...<<<<..<.<<<<<<<......>>>>>>>...>.<<<..>>>
.....>>>>.......>>>>...>.>>>>>......<<<<<<<..<<<<.
<.<<<<<.................>>>>>.><<<<<...<<<<....<<<
<<<<<<......>>>>..>>>>>...>>>>..>>>>>.<<<<....<<<<
...........>>>>....>>>>.>>>>....>>>>>>>.....<<....
...<<<<<.<..>>.>>>>....>>........<<<<<....<<<<<<<<
<<<<......>>>>>>>>>>>>..>>>>>.........<<<<<.<.....
........>.....<<<<<<<<<.<<<....<<<..>>>...>>>....>
>>>.>>>>>...>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8etg Chromatin localization of nucleophosmin organizes ribosome biogenesis.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		K9 T11 K12 F14 R16 Q18 D20 F22 K23 R24 V25 S28 W29 R30 K31 R33 R41 R42 F43 R44 P50 K51 I52 G53 Y54 G55 N56 K58 K59 R61 Y62 P65 L72 N75 E92 A94 G95 N96 S98 R100 K101
Binding residue
(residue number reindexed from 1)		K6 T8 K9 F11 R13 Q15 D17 F19 K20 R21 V22 S25 W26 R27 K28 R30 R38 R39 F40 R41 P47 K48 I49 G50 Y51 G52 N53 K55 K56 R58 Y59 P62 L69 N72 E89 A91 G92 N93 S95 R97 K98
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8etg, PDBe:8etg, PDBj:8etg
PDBsum8etg
PubMed36423630
UniProtP79015|RL32A_SCHPO Large ribosomal subunit protein eL32A (Gene Name=rpl3202)

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