Structure of PDB 7opd Chain e Binding Site BS01

Receptor Information
>7opd Chain e (length=711) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RDRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKV
SPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIM
IRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILL
LIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQ
RLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEH
LTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFG
TAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFI
NKRPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDV
FEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDM
ELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMI
KLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLV
LLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEV
EDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDA
AIVRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERD
KDNPNQYHYVA
Ligand information
>7opd Chain f (length=21) Species: 10090 (Mus musculus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
KKRFEVKKWNAVALWAWDIVV
Receptor-Ligand Complex Structure
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PDB7opd Structural basis of human transcription-DNA repair coupling.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		P520 I521 D522 L523 T524 V525 N526 I527 L528 E581
Binding residue
(residue number reindexed from 1)		P472 I473 D474 L475 T476 V477 N478 I479 L480 E533
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0061630 ubiquitin protein ligase activity
GO:0160072 ubiquitin ligase complex scaffold activity
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0001701 in utero embryonic development
GO:0006281 DNA repair
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006974 DNA damage response
GO:0007283 spermatogenesis
GO:0008283 cell population proliferation
GO:0008284 positive regulation of cell population proliferation
GO:0016567 protein ubiquitination
GO:0030097 hemopoiesis
GO:0030853 negative regulation of granulocyte differentiation
GO:0034644 cellular response to UV
GO:0035019 somatic stem cell population maintenance
GO:0042110 T cell activation
GO:0042254 ribosome biogenesis
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045732 positive regulation of protein catabolic process
GO:0048511 rhythmic process
GO:0051246 regulation of protein metabolic process
GO:0097193 intrinsic apoptotic signaling pathway
GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:2000001 regulation of DNA damage checkpoint
GO:2000819 regulation of nucleotide-excision repair
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0031461 cullin-RING ubiquitin ligase complex
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex
GO:0080008 Cul4-RING E3 ubiquitin ligase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7opd, PDBe:7opd, PDBj:7opd
PDBsum7opd
PubMed34526721
UniProtQ13619|CUL4A_HUMAN Cullin-4A (Gene Name=CUL4A)

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