Structure of PDB 6eml Chain e Binding Site BS01

Receptor Information
>6eml Chain e (length=261) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALPEKVIKAYTTVGSILKTWTHGKLPKLFKVIPSLRNWQDVIYVTNPEEW
SPHVVYEATKLFVSNLTAKESQKFINLILLERFRDNIETSEDHSLNYHIY
RAVKKSLYKPSAFFKGFLFPLVETGCNVREATIAGSVLAKVSVPALHSSA
ALSYLLRLPFSPPTTVFIKILLDKKYALPYQTVDDCVYYFMRFRILDDGS
NGEDATRVLPVIWHKAFLTFAQRYKNDITQDQRDFLLETVRQRGHKDIGP
EIRRELLAGAS
Ligand information
>6eml Chain 2 (length=1675) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcuca
uuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacu
gugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaaga
gauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauuc
auaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaa
auuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuu
caacggguaacggggaauaaggguucgauuccggagagggagccugagaa
acggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccu
aauucagggagguagugacaauaaauaacgauacagggcccauucggguc
uuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauugga
gggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguau
auuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguu
ggccggucggauuuccaacggggccuuuccuucuggcuaaccaggacuuu
uacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauau
uagcauggaauaauagaauaggacguuugguucuauuuuguugguuucua
ggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauu
gucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagca
uuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaag
augaucgucguagucuuaaccauaaacuaugccgacuagggaucgggugg
uguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuugg
guucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacgga
agggcaccaccaggaguggagccugcggcuuaauuuggaaacucaccagg
uccagacacaauaaggauugacagauugagagcucuuucuugauuuugug
ggugguggugcauggccguaguugguggagugauuugucugcuuaauugc
gauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcug
guuauccacuucuuagagggacuauauggaaguuugaggacaggucugug
augcccuuagacguucugggccgcacgcgcgcuacacugacggagccagc
gagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgu
gcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuagu
aagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacgcu
aguaccgauugaauggcuuagugaggccucaggaucugcuuagagaucuc
agagcggagaauuuggacaaacuuggucauuuagaggaacuaauuuccgu
aggugaaccugcggaaggaucauua
...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<...<......<<<
.<<<..<<....<<....<<..........>>...>>.>>......<<..
......<<<..<<..<<....<<<..................<.....<<
.<<<.....>>>.>>......>.........<<<<<..<<....>>..>>
>>><.<.<<<<<<......((((((...<<....>>.....<<......>
>>>>>>>.>...>...<<<<..<<<.....>>>.>>>>....>>>...>>
>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>..
....>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<.......
...>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<
.....>>>..>>>..>....>.>.....<<<<<<<<<.<<.....>>..>
>>>>>.>>>......<<..<...........>..>>.........<<<<<
((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>
>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<
<<...........>.>>>>.>>>>>>.......<<.....>.>......<
<<<<.<<.......<<...<.......>..<<<.....>>>....>>...
...>>.>>..>>>.........<....<<<<<.........))))))...
.>>>>>...>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.
<...<<<......>>>......>.>>>>>>..>>.......<<....>>.
..>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<
<......>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<
.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>
>>.>>>.<<<......<<<<....>>>>....>>>..]]]].}..<<.<<
<<<<<<..<<.<<<<<<..<<<.<<<<<<................<<<<<
.<....<<<<<.....<..<<.<<<........>>>.>>.>....>>>>>
...<<.<<<.....<<<<<.<<<.<<<<<....>>>...<<<......>>
>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>
>>...>>>>>..>>>>.>>....<..>.......>>>>>>>.>>>.....
..>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<.....
.<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>..
....<....<<<<<<..........>>>>>>....>.....>>>>>>...
.<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>....<
<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.........
.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>..<<<<<<
<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6eml Cryo-EM structure of a late pre-40S ribosomal subunit fromSaccharomyces cerevisiae.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		H226 G227 K228 P230 D296 H297 S298 Y312 N331 V332 A343 V345 S346
Binding residue
(residue number reindexed from 1)		H22 G23 K24 P26 D92 H93 S94 Y108 N127 V128 A139 V141 S142
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0030515 snoRNA binding
Biological Process
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364 rRNA processing
GO:0016973 poly(A)+ mRNA export from nucleus
GO:0030490 maturation of SSU-rRNA
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0030686 90S preribosome
GO:0030688 preribosome, small subunit precursor
GO:0032040 small-subunit processome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6eml, PDBe:6eml, PDBj:6eml
PDBsum6eml
PubMed29155690
UniProtP38333|ENP1_YEAST Essential nuclear protein 1 (Gene Name=ENP1)

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