Structure of PDB 5ll6 Chain e Binding Site BS01

Receptor Information

>5ll6 Chain e (length=97) Species: 4932 (Saccharomyces cerevisiae)

PKKRASNGRNKKGRGHVKPVRCVNCSKSIPKDKAIKRMAIRNIVEAAAVR
DLSEASVYPEYALPKTYNKLHYCVSCAIHARIVRVRSREDRKNRAPP

Ligand information

>5ll6 Chain 2 (length=1325)

uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcuca
uuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacu
gugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaaga
gauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauuc
auaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaa
auuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuu
caacggguaacggggaauaaggguucgauuccggagagggagccugagaa
acggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccu
aauucagggagguagugacaauaaauaacgauacagggcccauucggguc
uuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauugga
gggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguau
auuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguu
ggccggucggauuuccaacggggccuuuccuucuggcuaaccuugagucc
uuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguu
caaagcaggcguauugcucgaauauauuagcauggaauaauagaauagga
cguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagg
gacggucgggggcaucaguauucaauugucagaggugaaauucuuggauu
uauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaa
ucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucu
uaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacc
cacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguau
ggucgcaaggcugaaacuuaaaggaauugacggaagguugguggagugau
uugucugauaacgcccuuuguacacaccgcccgucgcuaguaccgauuga
auggcuuagugaggccucaggaucugcuuagagaucucagagcggagaau
uuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuucc
guaggugaaccugcggaaggaucau

...<<<<<...[[[[>>>>>[[[[.((((((................[[[
.[[[..<<....<<....<<..........>>...>>.>>......{{..
......[[[..{{..{{....[[[..................<<....<<
.<<<.....>>>.>>.....>>.........<<<<<..<<....>>..>>
>>>[...((((((......<<<<<<<.<<<....>>>.............
.)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}
}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>..
....>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<.......
...>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<
.....>>>..>>>...............<<<<<<<<..<<......>>..
>>>>>.>>>......<<..<...........>..>>.........<<<<<
((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))
]]]].........[[[<<.......{{...[[[.[[....<<<<<<.<<<
<<............>>>>>.>>>>>>....<<<<<...............
..................>>>>>...<<<<<.<<.......<<...<...
....>..<<<.....>>>....>>......>>.>>..>>>.........[
....(((((((......>>>>>>>..)))))))...].....]]....<<
<<<<.<<...<<<<..<<<.<<<<<<.<...<<<......>>>......>
.>>>>>>.>>>.......<<....>>...>>>>...>>>>>.>>>...]]
]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>
>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>
>>>>>>>..>>>...<<..>>>>...>>.....>>>.]]].<<<......
<<<<....>>>>....>>>..]]]]..<<<<<.<<<<...<<<<......
>>........>>..>>>>>>>.>>....<..<<.<..<<<<.<<....<<
<<<<<<.<<<..<.<<..<...<<<<<<<..........>>>>>>>...>
..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<
<<<<<....>>>>>>>>>.......

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5ll6 Structure of the 40S-ABCE1 post-splitting complex in ribosome recycling and translation initiation.
• Resolution: 3.9 Å
• Binding residue (original residue number in PDB): P2 K3 K4 R5 S7 N8 R10 N11 K13 G14 R15 H17 K19 K32 K34 K37 R38 K70 V75 S76 I79 H80 V84 R85 R87 S88 R92 K93 R95 P97
• Binding residue (residue number reindexed from 1): P1 K2 K3 R4 S6 N7 R9 N10 K12 G13 R14 H16 K18 K31 K33 K36 R37 K69 V74 S75 I78 H79 V83 R84 R86 S87 R91 K92 R94 P96

Gene Ontology

Molecular Function

• GO:0003729 mRNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding
• GO:0008270 zinc ion binding

Biological Process

• GO:0000054 ribosomal subunit export from nucleus
• GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0042255 ribosome assembly

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:0030686 90S preribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:5ll6, PDBe:5ll6, PDBj:5ll6
• PDBsum: 5ll6
• PubMed: 28368393
• UniProt: P39938|RS26A_YEAST Small ribosomal subunit protein eS26A (Gene Name=RPS26A)