Structure of PDB 5ndv Chain d3 Binding Site BS01

Receptor Information
>5ndv Chain d3 (length=144) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GKGKPRGLNSARKLRVHRRNNRWAENNYKKRLLGTAFKSSPFGGSSHAKG
IVLEKLGIESKQPNSAIRKCVRVQLIKNGKKVTAFVPNDGCLNFVDENDE
VLLAGFGRKGKAKGDIPGVRFKVVKVSGVSLLALWKEKKEKPRS
Ligand information
>5ndv Chain 6 (length=1683) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcuca
uuaaaucaguuaucguuuauuugauaguuccuuacaugguauaacugugg
uaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagaug
uauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaa
uaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuu
cugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaac
ggguaacggggaauaaggguucgauuccggagagggagccugagaaacgg
cuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauu
cagggagguagugacaauaaauaacgauacaggggucuuguaauuggaau
gaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggu
gccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguug
caguuaaaaagcucguaguugaacuuugggcccgguuaacggggccuuuu
uacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauau
uagcauggaauaauagaauaggacguuugguucuauuuuguugguuucua
ggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauu
gucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagca
uuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaag
augaucagauaccgucguagucuuaaccauaaacuaugccgacuagggau
cgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaag
ucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaau
ugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaa
cacggggaaacucaccagguccagacacaauaaggauugacagauugaga
gcucuuucuugauuuugugggugguggugcauggccguucuuaguuggug
gagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacua
aauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucg
guuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuua
gacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaac
cuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggau
agagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaag
ucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccguc
gcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagcg
gagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaag
guuuccguaggugaaccugcggaaggaucauua
...<<<<..{.((((.>>>><<<<.<<<<<<.....<...<......<<<
.<<<..<<....<<....<<..........>>...>>.>>......<<..
......<<<..<<..<<....<<<..............<.....<<.<<<
.....>>>.>>......>.........<<<<<..<......>..>>>>>.
...<<<<<<......{..(((..<<......>>....<<......>>>>>
>>>.........<<<<..<<<.....>>>.>>>>....>>>...>>>>..
>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......
>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>
>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<....
.>>>..>>>..>....>.......<<<<<<<<<..>.>>>>>.>>>....
..<<..<...........>..>>.........<<<<<((......<<<<.
....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........
<<<[[.....<.<<...<<<.<<....<<<<<<.<<..>>.>>>>>>..<
<<<<.<<.......<<...<.......>..<<<.....>>>....>>...
...>>.>>..>>>.........<<<..<<<<<<<.......)))..}..>
>>>>>>.>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.
<...<<<......>>>......>.>>>>>>..>>.......<<....>>.
..>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<
<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<
<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>
>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}
<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<......
..>>..........<<<<<......<<<<<........<<.<<<......
..>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<
<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<
<..<<<<<.<<<<<<<..>>>>>>>...>>>>>..>>>>.>>....<<<<
<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>.
.....>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<
<..<<<<....>>>>..>>....>>.......>>>>>>>...........
<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<
.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<
..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<...>>>>
>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>...
..<<<<<<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5ndv Aminoglycoside interactions and impacts on the eukaryotic ribosome.
Resolution3.3 Å
Binding residue
(original residue number in PDB)
G2 K3 G4 K5 P6 R7 G8 N10 R13 K14 R19 R20 N22 R23 W24 A25 E26 K30 R32 F38 K39 S40 S46 S47 H48 A49 K50 K62 Q63 N65 S66 A67 I68 R69 K70 K78 P88 N89 D90 G91 G106 G108 R109 K110 K114 G115 D116 R121 K126 L133 W136 K139 K140
Binding residue
(residue number reindexed from 1)
G1 K2 G3 K4 P5 R6 G7 N9 R12 K13 R18 R19 N21 R22 W23 A24 E25 K29 R31 F37 K38 S39 S45 S46 H47 A48 K49 K61 Q62 N64 S65 A66 I67 R68 K69 K77 P87 N88 D89 G90 G105 G107 R108 K109 K113 G114 D115 R120 K125 L132 W135 K138 K139
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006412 translation
GO:0006450 regulation of translational fidelity
GO:1990145 maintenance of translational fidelity
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:5ndv, PDBe:5ndv, PDBj:5ndv
PDBsum5ndv
PubMed29208708
UniProtP0CX29|RS23A_YEAST Small ribosomal subunit protein uS12A (Gene Name=RPS23A)

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