Structure of PDB 8pj5 Chain d Binding Site BS01

Receptor Information
>8pj5 Chain d (length=142) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENW
FYTRAASTARHLYLRGGAGVGSMTKIYGGRQRNGVMPSHFSRGSKSVARR
VLQALEGLKMVEKDQDGGRKLTPQGQRDLDRIAGQVAAANKK
Ligand information
>8pj5 Chain A (length=1754) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucugaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucgcuccuacuuggauaacugug
guaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggg
gggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucg
cacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacu
uucgaugguagucgccgugccuaccauggugaccacgggugacggggaau
caggguucgauuccggagagggagccugagaaacggcuaccacauccaag
gaaggcagcaggcgcgcaaauuacccacucccgacccggggagguaguga
cgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugagu
ccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugcca
gcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcagu
uaaaaagcucguaguuggaucuugggagcgggcgggcgguccgccgcgag
gcgagccaccgcccguccccgccccucucggcggcccgaagcguuuacuu
ugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcag
cuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaac
ugaggccaugauuaagagggacggccgggggcauucguauugcgccgcua
gaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuug
ccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacga
ucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcgg
cggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuu
uggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugac
ggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacg
ggaaaccucacccggcccggacacggacaggauugacagauugauagcuc
uuucucgauuccgugggugguggugcauggccguucuuaguugguggagc
gauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacua
guuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaa
guggcguucagccacccgagauugagcaauaacaggucugugaugcccuu
agauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccu
acccuacgccggcaggcgcggguaacccguugaaccccauucgugauggg
gaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugc
gggucauaagcuugcguugauuaagucccugcccuuuguacacaccgccc
gucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgc
cgggggcccuggcggagcgcugagaagacggucgaacuugacuaucuaga
ggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggauc
auua
...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<.<....<<....<<<<<.............<<.....<<.<<
<.....>>>.>>......>>.........<<<<...<<<<........>>
>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<
<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<
....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<
....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....
>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>..
.>>.>.....<..<...<<..<<....>>..>>.....>...>.....<<
..<...........>..>>.........<<<<<((....<.<<<<.....
<<..))>>.......>>>>>>>>>>..>>>>>>.>>>.........<.<(
(.....<.<<...<<<.<<.....<..<<<<<<<<<<<<<.<<<<....>
>>>....>>>>>>>>..>>>>>.><<.............>>...<<<<<<
.<.......<<...<.......>.<<<<.......>>>>...>>......
>.>>>..>>>........<.<<.<<<.<..................>..>
>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...
<<<......>>>......>>>>>>>>..>>.......<<....>>...>>
>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.
<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<
<<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>...
..>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<
<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>
..........<<<<<.<....<<<<<<.......<<.<<<........>>
>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<..
..>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<
<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....
<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.
....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.....
..<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.
..<.<<<<<..........>>>>>>....>.....>>>>>.....<<<<<
<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<
<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.....
..................>>>>>...>>.>>>>..>>>.>>>>>>>>...
>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>.....
....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8pj5 Structural basis for translational control by the human 48S initiation complex from codon scanning toward subunit joining
Resolution2.9 Å
Binding residue
(original residue number in PDB)
G3 V4 Q12 V15 R16 W33 V37 K38 L39 K43 E44 L45 P47 Y48 R56 S59 R62 H63 R67 G71 V72 G73 S74 K77 I78 R82 R84 G86 V87 M88 P89 S90 H91 F92 S96 K97 S98 R101 Q105 G120 R121 P125 Q128 R129 D132 R133
Binding residue
(residue number reindexed from 1)
G1 V2 Q10 V13 R14 W31 V35 K36 L37 K41 E42 L43 P45 Y46 R54 S57 R60 H61 R65 G69 V70 G71 S72 K75 I76 R80 R82 G84 V85 M86 P87 S88 H89 F90 S94 K95 S96 R99 Q103 G118 R119 P123 Q126 R127 D130 R131
External links
PDB RCSB:8pj5, PDBe:8pj5, PDBj:8pj5
PDBsum8pj5
PubMed
UniProtP39019|RS19_HUMAN Small ribosomal subunit protein eS19 (Gene Name=RPS19)

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