Structure of PDB 7nkl Chain d Binding Site BS01

Receptor Information

>7nkl Chain d (length=327) Species: 246196 (Mycolicibacterium smegmatis MC2 155)

QQLIRQLRTGLGAEAVNKAAEIVRAHVADPQAQSATVDRFLSELEQMAPS
STSRLRAASRQSLAALVEKFDSVAGGLDADGLTNLADELASVAKLLLSET
ALNKHLAEPTDDSAPKVRLLERLLSDKVSATTLDLLRTAVSNRWSTESNL
IDAVEHTARLALLKRAEIAGEVDEVEEQLFRFGRVLDAEPRLSALLSDYT
TPAEGRVALLDKALTGRPGVNQTAAALLSQTVGLLRGERADEAVIDLAEL
AVSRRGEVVAHVSAAAELSDAQRTRLTEVLSRIYGRPVSVQLHVDPELLG
GLSITVGDEVIDGSIASRLAAAQTGLP

Ligand information

>7nkl Chain C (length=27) Species: 246196 (Mycolicibacterium smegmatis MC2 155)

AADIEGAIEDYVSSFSEGLPSLDEHSV

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7nkl Structure of the ATP synthase from Mycobacterium smegmatis provides targets for treating tuberculosis.
• Resolution: 3.67 Å
• Binding residue (original residue number in PDB): E306 R308 L312 T317 L326 A330 R334
• Binding residue (residue number reindexed from 1): E189 R191 L195 T200 L209 A213 R217

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0015078 proton transmembrane transporter activity
• GO:0046933 proton-transporting ATP synthase activity, rotational mechanism

Biological Process

• GO:0006754 ATP biosynthetic process
• GO:0015986 proton motive force-driven ATP synthesis
• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)
• GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)

External links

• PDB: RCSB:7nkl, PDBe:7nkl, PDBj:7nkl
• PDBsum: 7nkl
• PubMed: 34782468
• UniProt: A0R203|ATPFD_MYCS2 ATP synthase subunit b-delta (Gene Name=atpFH)