Structure of PDB 4kzz Chain d Binding Site BS01

Receptor Information

>4kzz Chain d (length=53) Species: 9986 (Oryctolagus cuniculus)

QQLYWSHPRKFGQGSRSCRVCSNRHGLIRKYGLNMCRQCFRQYAKDIGFI
KLD

Ligand information

>4kzz Chain i (length=1797)

uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucgcuccucuccuacuuggauaa
cugugguaauucuagagcuaauacaugccgacggcgcugacucccuuugu
gugggaugcgugcauuuaucagaucaaaaccaacccggucagccuccccg
ccggccggggggguggggcggcggcuuuggugacucuagauaaccucggg
ccgaucgcagcccuccguggcggcgacgacccauucgaacgucugcccua
ucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacg
gggaaucaggguucgauuccggagagggagccugagaaacggcuaccaca
uccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagg
uagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauugga
augaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucug
gucgcagcagccgcgguaauuccagcuccaauagcguauauuaaaguugc
ugcaguuaaaaagcucguaguuggaucuuggagggugcguagcgggccac
cgcccguccccgcccugccuccgaagcguuuacuuugaaaaaauuagagu
guucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaa
uaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaa
gagggacggccgggggcauucguauugcgccgcuagaggugaaauucuug
gaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuuca
uuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucgua
guuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccau
gacccgccgggcagcuuccgggaaaccaaagucuuuggguuccgggggga
guaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccacca
ggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccgg
cccggacacggacaggauugacagauugauagcucuuucucgauucugug
ggugguggugcauggccguucuuaguugguggagcgauuugucugguuaa
uuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccg
agcggucggcgucccccaacuucuuagagggacaaguggcguucagccac
ccgagauugagcaauaacaggucugugaugcccuuagaugucggggcugc
acgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcagg
cgcggguaacccguugaaccccauucgugauggggaucggggauugcaau
uauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcg
uugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauu
ggaugguuuagugaggcccucggaucggcccgccggggucggcccacggc
ccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaagua
aaagucguaacaagguuuccguaggugaaccugcggaaggaucauua

...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.
[[[..<<....<<....<<..........>>...>>.>>......{{...
.....[[[......{{....[[[....................<<.....
<<.<<<.....>>>.>>......>>.........<<<...<<.<......
>.>>...>>>.[[..(((((.....<<<<<<<<<<<<.<...<.<<<...
.......>..>.>.>.....>>>>..............)))))......]
]...<<<<.<<<......>>>.>>>>....]]]...}}....]]].<<<.
...<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<
<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.
<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>
>......}}.......<<<<<<<<<.<<<....>>>.>.>>>>>.>>>..
....<<..<...........>..>>.........<<<<<((......<<<
<.....<<..))>>.......>>>>.>>>>>..)))))).]]].......
.....{{.......{{...[[[.[[....<..<<<...<..<........
>..>...>>>..>...<<.<...>.>>..<<<<<..<.......<<...<
.......>.<<<<.......>>>>...>>......>..>>..>>>.....
..[[....(((((((.....>>>>>>>>>.)))))))...]]....]]..
..<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>...
...>>>>>>>.>.>>.......<<....>>...>>>>..>..>>>.>>>.
..]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...
>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>
>>>>>>>>>.>..>>>...<<..}}>>...>>.....>>>.....<<<..
....<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<..
<<<<<..<<<.<<<<<<......<<........>>..........<<<<<
......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>
.<.<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<....
..>>>...>>.>>>....<<<...<...<<<<..<<<<....<<<..<<<
<....>>>>.>>>....>>>>..>>>>..>.....<<<<<.....>>>>>
........>>>....>>>.>>>...>.>>>>>>>>.....>>>>>...>>
.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>
>>.>>>....>.........>>>.>>............<<<<<.......
...>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>
>>......>>...>>>>>>>>>>.>>.......<<.<..<<<<.<<....
<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<<<.....>>>>
>>>>>>.>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>
...>.>>.........<<<<<<<<<....>>>>>>>>>.........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4kzz The initiation of mammalian protein synthesis and mRNA scanning mechanism.
• Resolution: 7.0305 Å
• Binding residue (original residue number in PDB): L6 W8 H10 P11 R12 K13 F14 G15 Q16 R19 R22 N26 R27 H28 G29 R32 K33 Y34 R40 Q41 R44 Q45 L55 D56
• Binding residue (residue number reindexed from 1): L3 W5 H7 P8 R9 K10 F11 G12 Q13 R16 R19 N23 R24 H25 G26 R29 K30 Y31 R37 Q38 R41 Q42 L52 D53

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0008270 zinc ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005783 endoplasmic reticulum
• GO:0005791 rough endoplasmic reticulum
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:4kzz, PDBe:4kzz, PDBj:4kzz
• PDBsum: 4kzz
• PubMed: 23873042
• UniProt: G1U7M4|RS29_RABIT Small ribosomal subunit protein uS14 (Gene Name=RPS29)