Structure of PDB 8gzu Chain c2 Binding Site BS01

Receptor Information

>8gzu Chain c2 (length=599) Species: 312017 (Tetrahymena thermophila SB210)

MWGNLWTEASYQLNFNIGFSSLRSDVLIHLAQWQYWWWFWFALIWSFYYF
IILKVARFRVLKMRPKISTSYRPHGKWGDFLACIIPLIWCINILTNSNLI
LRLIEWQNESSLFTVRVRARQWYWIYKFELKNFTDILSTPKNIGNNRWQI
NTFGELQTADDYLHVLQLRSQNKWVKNYWNRSLQETGKTNKAHVISPQEQ
LRLSLINQYKSLNLSSSIKHNAPFINRDLYVFDDLFSYNLGDITTKKSLF
NDKNSFLTSYSYLNNNSWNNNEFDLIDNLPFTTLFDNNDLFNNYKSFFQD
SIFNSPKKQLSSDSKQLFKHIIYRSIKNNIIQDYTKLVKHEDFDEYSRWI
KRSPGEVLPLRIIKYPLGLETIHNNIFENTNNEGNVELFRLRFNSNSSKM
QHKLVQDTIYLTLKQKRYNRKKVVAPQIKYYKKTDLVKYTGKPYLSNDKL
LKQSIYDQTTQYKLIKKNKKRGELIPVTLARRILRTKKTLVLPAHVNITL
ITNSYDIVHSWFIPGLGIKLDCVPGRSTHHTFFIDNVGFYYGQCAEICGR
YHHHMPIRVCALPFEHFLLWWNTFGLPKMLNTVSRKRFETHYELRKYSW

Ligand information

• Ligand ID: CU
• InChI: InChI=1S/Cu/q+2
• InChIKey: JPVYNHNXODAKFH-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Cu+2]
  CACTVS 3.341: [Cu++]
• Formula: Cu
• Name: COPPER (II) ION
• DrugBank: DB14552
• PDB chain: 8gzu Chain c2 Residue 701

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8gzu Structures of Tetrahymena thermophila respiratory megacomplexes on the tubular mitochondrial cristae.
• Resolution: 4.18 Å
• Binding residue (original residue number in PDB): E551 C553
• Binding residue (residue number reindexed from 1): E546 C548
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 7.1.1.9: cytochrome-c oxidase.

Gene Ontology

Molecular Function

• GO:0004129 cytochrome-c oxidase activity
• GO:0005507 copper ion binding
• GO:0016491 oxidoreductase activity

Biological Process

• GO:0042773 ATP synthesis coupled electron transport
• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0005739 mitochondrion
• GO:0016020 membrane

External links

• PDB: RCSB:8gzu, PDBe:8gzu, PDBj:8gzu
• PDBsum: 8gzu
• PubMed: 37248254
• UniProt: Q950Y9