Structure of PDB 5obm Chain c1 Binding Site BS01

Receptor Information
>5obm Chain c1 (length=142) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TVQSERAFQKQPHIFNNPKVKTSKRTKRWYKNAGLGFKTPKTAIEGSYID
KKCPFTGLVSIRGKILTGTVVSTKMHRTIVIRRAYLHYIPKYNRYEKRHK
NVPVHVSPAFRVQVGDIVTVGQCRPISKTVRFNVVKVSAAAG
Ligand information
>5obm Chain 6 (length=1739) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcuca
uuaaaucaguuaucguuuauuugauaguucccuacaugguauaacugugg
uaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagaug
uauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaa
uaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuu
cugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaac
ggguaacggggaauaaggguucgauuccggagagggagccugagaaacgg
cuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauu
cagggagguagugacaauaaauaacgauacaguuguaauuggaaugagua
caauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccag
cagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguu
aaaaagcucguaguugaacuuugggcccgguuggccgguacuggauuucc
aacggggccuuuccuucuggcuaacuggcgaaccaggacuuuuacuuuga
aaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcaugg
aauaauagaauaggacguuugguucuauuuuguugguuucuaggaccauc
guaaugauuaauagggacggucgggggcaucaguauucaauugucagagg
ugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaa
ggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucag
auaccgucguagucuuaaccauaaacuaugccgacuagggaucggguggu
guuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggg
uucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaa
gggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggga
aacucaccagguccagacacaauaaggauugacagauugagagcucuuuc
uugauuuugugggugguggugcauggccguucuuaguugguggagugauu
ugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauagugg
ugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaag
ccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucu
gggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccg
agaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauu
guaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagc
uugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguac
cgauugaauggcuuagugaggccucaggaucugcuuagagaagccaucuc
agagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucgu
aacaagguuuccguaggugaaccugcggaaggaucauua
...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<...<......<<<
.<<<..<<....<<....<<..........>>...>>.>>......<<..
......<<<..<<..<<....<<<..............<.....<<.<<.
......>>.>>......>.........<<<<<..<<....>>..>>>>>.
...<<<<<<......(((((((....<..>.................>>>
>>>.........<<<<..<<<.....>>>.>>>>....>>>...>>>>..
>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......
>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>
>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<....
.>>>..>>>..>....>.>.....<<<<<<<..>>>>.>>.>.....<<.
.<...........>..>>.........<<<<<((....<.<<<<.....<
<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<[[
.....<.<<...<<<.<<....<<<<<<.<<<..<<<<..>>>>......
>>>.>>>>>>....<<<<<<............>>>>>>...<<<<<.<<.
......<<...<.......>..<<<.....>>>....>>......>>.>>
..>>>.........<<<..<<<<<<<<.....))))))).>>>>>>>>.>
>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<.
.....>>>......>.>>>>>>..>>......<<<....>>>..>>>>..
.>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.....
....>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.
<<<<.....>.>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>
>.>>>.<<<......<<<......>>>....>>>..]]]].}<<<<<.<<
<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>....
......<<<<<.<....<<<<<........<<.<<<........>>>.>>
......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>
>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<
.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>
>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>
>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<.
...>>>>..>>....>>.......>>>>>>>...........<<<<<<..
........>>>>>>..........>>>>>>....<<<<<<<<.......>
>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<
<....<<<<<<<<.<<<..<.<<......<<<<<<<.<<<<.....>>>>
.>>>>>>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>.
..>.....<<<<<<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
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PDB5obm Aminoglycoside interactions and impacts on the eukaryotic ribosome.
Resolution3.4 Å
Binding residue
(original residue number in PDB)
E10 A12 Q14 P17 H18 F20 K26 T27 S28 K29 W34 K36 N37 A38 G39 L40 K46 E50 K57 S65 I66 R67 G68 K69 K79 M80 H81 T83 Y90 H92 K96 R99 K102 R103 H104 K105 N106 Q127 R129 P130 I131 S132 K133 T134 R136 F137
Binding residue
(residue number reindexed from 1)
E5 A7 Q9 P12 H13 F15 K21 T22 S23 K24 W29 K31 N32 A33 G34 L35 K41 E45 K52 S60 I61 R62 G63 K64 K74 M75 H76 T78 Y85 H87 K91 R94 K97 R98 H99 K100 N101 Q122 R124 P125 I126 S127 K128 T129 R131 F132
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0030686 90S preribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:5obm, PDBe:5obm, PDBj:5obm
PDBsum5obm
PubMed29208708
UniProtP0CX47|RS11A_YEAST Small ribosomal subunit protein uS17A (Gene Name=RPS11A)

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