Structure of PDB 8qsj Chain c Binding Site BS01

Receptor Information

>8qsj Chain c (length=286) Species: 9606 (Homo sapiens)

VKKGFRAAFRFQKELERQRLLRCPPPPVRRSEKPNWDYHAEIQAFGHRLQ
ENFSLDLLKTAFVNSCYIKSEEAKRQQLGIVLLNLKSNQELSEQGTSFSQ
TCLTQFLEDEYPDMPTEGIKNLVDFLTGEEVVCHVARNLAVEQLTLSEEF
PVPPAVLQQTFFAVIGALLQSSGPERTALFIRDFLITQMTGKELFEMWKI
INPMGLLVEELKKRNVSAPESRLTRQSGGTTALPLYFVGLYCDKKLIAEG
PGETVLVAEEEAARVALRKLYGFTENRRPWNYSKPK

Ligand information

>8qsj Chain A (length=1418)

gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagc
caaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcg
caauagauauaguaccgcaagggaaagaugaaaaauaccaagcauaauau
agcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaa
cuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccu
aagaacagcuaaaagagcacacccgucuauguagcaaaauagugggaaga
uuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguc
caagauagaaucuuaguucaacuuuaaauuugcccacagaacccucuaaa
uccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggaca
cuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguagg
ccuaaaagcagccaccaauuaagaaagcguucaagcucaacacaaaaaau
cccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacc
cuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccg
cauaagccugcgucagacacugaacugacaauuaacagcccaauaucuac
aaucaaccaacaagucauuauuacccucacugucaacccaacacaggcau
gcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuacc
ccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggca
ccgccgcuccacgaggguucagcugucucuuacuuuuaaccagugaaauu
gaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccua
uggagcuuuaauuuauuaaugcaaacaaccugcauuaaaaauuucgguug
gggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuu
caccagucaaagcgaacacucaauugauccaauaacuugaccaacggaac
aaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaac
aauagggcgaccucgauggaucaggacaucccgauggugcagccgcuauu
aaagguucguuuaacgauuaaaguccuacgugaucugaguucagaccgga
guaauccaggucgguuucuaucuacuuaaauuccucccuguacgaaagga
caagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauuc
ucaacuuaguauacccaccccacccaagaacaggguuuauauauauauau
auauauauauauauauau

<<<.......<<<<....................................
.<<....>>.........<.....<<.....>>....>........>>.>
>.............<<....>>..................>>>.......
....<<<.......>>>...<.<........>.>.<<<<<<.........
<<<.<<..<<....>>...>>.>>>...<<.<..<<<<<.<.....<<<<
<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>....
>>>.>>>>>...<<.......>>......>.>>>>...>..>.>>..<<<
<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<..........
>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>.
..<<<......>>>....<<<.<<<...<..............<....<<
<.........>>>....>.......<<<......>>>.............
..............>...>>>>>>........>>>>>>...<<<<<....
..>>>>>.........>>>>>><......<<..<<<....>>><<<<..<
<<<........<<<<<........>>>>>......<<<...<<<<.....
..................>>>>.......>>>.....<<......>>.>>
>>.....>>>>..<<<<...<<<<<<<<.<<................<<<
<<<..<<<.........>>>...<<<<<<.............>>>>>>..
..<<.>>....>>.>>>>........>>.>>>>>>>>>>>>.>>.....>
.....<<<<<........>>>>>.......<<..<<<.<<<.....<<<<
.<<<<<<..<<<<<.<<<<<<<<.......>>>>>>>>>>>>>..<<<<.
....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.
....>>>>..>>>.....>>.........<<<....>>>...........
.>>>>..>>>>>>.......<<<...<<<<<<<...<<.......>>...
>>>>>>>>>.>.....<<<<.<<<<<<..<<.<<<<<<......>>>>>>
...>>.<<<<<.>>>>>.....>>>>>..>...>>>>......<<<<<<<
....>>>.>>>>...>>>..>>>.>>...<<<.<<<..............
...>>>.>>><<<<<...<<<....>>>.>>>>>......<<<.......
.....>>>.............<<<<.......>>>>.<<<<<<..>>>>>
>.<<<<<<<..>>>>>>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8qsj Structural insights into the role of GTPBP10 in the RNA maturation of the mitoribosome.
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): V31 K33 G34 F35 R36 F39 K43 L45 R49
• Binding residue (residue number reindexed from 1): V1 K3 G4 F5 R6 F9 K13 L15 R19

Enzymatic activity

• Enzyme Commision number: 3.1.26.-

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003725 double-stranded RNA binding
• GO:0004519 endonuclease activity
• GO:0004525 ribonuclease III activity
• GO:0005515 protein binding

Biological Process

• GO:0006396 RNA processing
• GO:0032543 mitochondrial translation
• GO:0070125 mitochondrial translational elongation

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:0005886 plasma membrane
• GO:0016604 nuclear body
• GO:0070877 microprocessor complex
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8qsj, PDBe:8qsj, PDBj:8qsj
• PDBsum: 8qsj
• PubMed: 38042949
• UniProt: Q9H9J2|RM44_HUMAN Large ribosomal subunit protein mL44 (Gene Name=MRPL44)