Structure of PDB 8oz0 Chain c Binding Site BS01

Receptor Information
>8oz0 Chain c (length=129) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VRMNVLADALKSINNAEKRGKRQVLIRPCSKVIVRFLTVMMKHGYIGEFE
IIDDHRAGKIVVNLTGRLNKCGVISPRFDVQLKDLEKWQNNLLPSRQFGF
IVLTTSAGIMDHEEARRKHTGGKILGFFF
Ligand information
>8oz0 Chain W (length=1716) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucugaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucgccuacuuggauaacuguggu
aauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggg
gaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgca
cgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuu
cgaugguagucgccgugccuaccauggugaccacgggugacggggaauca
ggguucgauuccggagagggagccugagaaacggcuaccacauccaagga
aggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacg
aaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugagucc
acuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagc
agccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguua
aaaagcucguaguuggaucuugggagcggccccgccccucucggcggccc
gaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgc
cuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuugu
ugguuuucggaacugaggccaugauuaagagggacggccgggggcauucg
uauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccaga
gcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucgga
gguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccg
accggcgaugcggcggcguuauucccaugacccgccgggcagcuuccggg
aaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacu
uaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaau
uugacucaacacgggaaaccucacccggcccggacacggacaggauugac
agauugauagcucuuucucgauuccgugggugguggugcauggccguucu
uaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucu
ggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuu
cuuaagggacaaguggcguucagccacccgagauugagcaauaacagguc
ugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcu
cagcgugugccuacccuacgccggcaggcgcggguaacccguugaacccc
auucgugauggggaucggggauugcaauuauuccccaugaacgaggaauu
cccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuug
uacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucg
gaucggccccgccgggggcccuggcggagcgcugagaagacggucgaacu
ugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaacc
ugcggaaggaucauua
...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<...<....<.....<<..........>>....>.>.......<<...
.....<<<.<....<<...<.<<<<...........<<.....<<.<<..
.....>>.>>......>>.........<<<<...<<<<........>>>>
...>>>><<..<<<<<.............>>>>>......>>....<<<.
.<<<......>>>.>>>..>>>>.>...>>..>.>>>.<<<....<<<..
..<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<..
..>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>
.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>
>.>.....<..<<<<<<............>>.>>>>...>......<<..
<...........>..>>.........<<<<<((....<.<<<<.....<<
..))>>.......>>>>>>>>>>..>>>>>>.>>>.........<.<((.
....<.<<...<<<.<<.....<<..........>>.<<...........
..>>...<<<<<<.<.......<<...<.......>.<<<<.......>>
>>...>>......>.>>>..>>>........<.<<.<<<..<<.......
........>>..>>>.>>.>....>>....<<<<<<..<...<<<<..<<
..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......
<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<
<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.
<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<.
.))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>
>..)))).]<<<...<<<<<<<..<<..<<<<<..<<<.<<<<<<.....
.<<........>>..........<<<<<......<<<<<<.......<<.
<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<..
..<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<.
......<<<<...<<<<<<<<<<<.......>>>>.>>>>.....>>>..
.>>>.>......<<<<<.....>>>>>........>>>....>>>.>>>.
....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<..<<..
......<.......<<<.<<<<....>>>>.>>>....>.........>>
..>>......<.....<<<<<..........>>>>>.....>.....>>>
>>.....<<<<<<<<.......>>>>>>>>......>>...>>.>>>>>.
>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<.
..<<<<<.......................>>>>>...>>.>>>>..>>>
.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>
>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8oz0 The structure of a human translation initiation complex reveals two independent roles for the helicase eIF4A.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		V2 M4 N16 R20 R28 K32 R57 A58 K71 V74 S76 R78 D80 Q82 T105 T106 S107 H120 G122 K124
Binding residue
(residue number reindexed from 1)		V1 M3 N15 R19 R27 K31 R56 A57 K70 V73 S75 R77 D79 Q81 T104 T105 S106 H119 G121 K123
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0008284 positive regulation of cell population proliferation
GO:0009615 response to virus
GO:0042274 ribosomal small subunit biogenesis
GO:0045787 positive regulation of cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0032040 small-subunit processome
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8oz0, PDBe:8oz0, PDBj:8oz0
PDBsum8oz0
PubMed38287194
UniProtP62244|RS15A_HUMAN Small ribosomal subunit protein uS8 (Gene Name=RPS15A)

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