Structure of PDB 8om2 Chain c Binding Site BS01

Receptor Information
>8om2 Chain c (length=483) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KELRLLSKTLQGQSYRDQLELNPDVSKAINNNIMAVHIPNNLRRVATNYY
KEIQEPNSLHRPCRTKMEVDAHIASIFLQNYGSIFQSLKELQKRVGPDNF
KPQRILDVGYGPATGIVALNDILGPNYRPDLKDAVILGNAEMQERAKIIL
SRQLNEVVDTTKKINIMTNLRSSIPASKEYDLIILTHQLLHDGNQFPIQV
DENIEHYLNILAPGGHIVIIERGNPMGFEIIARARQITLRPENFPDEFGK
IPRPWSRGSSNYFLKVIAPCPHQRKCPLQVGNPNFYTHKEGKDLKFCNFQ
KSIKRPKFSIELKKGKLLATSWDRNGRDYEILNYSYLIFERSHKDENTLK
EIKKLRNENVNGKYDIGSLGDDTQNSWPRIINDPVKRKGHVMMDLCAPSG
ELEKWTVSRSFSKQIYHDARKSKKGDLWASAAKTQIKGLGDLNVKKFHKL
EKERIKQLKKEERQKARKAMESYNELEDSLQFD
Ligand information
>8om2 Chain r (length=1486) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auaagaauaugauguugguucagauuaagcgcuaaauaaggacaugacac
augcgaaucauacguuuauuauugauaagauaauaaauaugugguguaaa
cgugaguaauuuuauuaggaauuaaugaacuauagaauaagcuaaauacu
uaauauauaaaaaggauauauaauauauuuaucuauagucaagccaauaa
ugguuuagguaguagguuuauuaagaguuaaaccuagccaacgauccaua
aucgauaaugaaaguuagaacgaucacguugacucugaaauauagucaau
aucuauaagauacagcagugaggaauauuggacaaugaucgaaagauuga
uccaguuacuuauuaggaugauauauaaauauauauauauaaauugauua
aaaauaaaauccauaaauaauuaaaauaaugauauuaauuaccauauauu
uuuauauggauauauuuuaauaguccugacuaauauuugugccagcaguc
gcgguaacacaaagagggcgagcguuaaucauaaugguuuaaaggauccg
uagaaugaauuauauauuauaauuuagaguuaauaaaauuaauuaaagaa
uuauaauaguaaagaugaaauaaauaauuauaagacuaauauaugugaaa
auauuaauuaaauauuaacugacauugagggauuaaaacuagaguagcga
aacggauucgauacccguguaguucuaguaguaaacuaugaauacaauua
uuuauauauauauauauaaauaauaaaugaaaaugaaaguauuccaccug
aagaguacguuagcaauaaugaaacucaaaacaauagacgguuacagacu
uaagcaguggagcauguuauuuaauucgauaauccacgacuaaccuuacc
auauuuugaauauuauaauaauuaaauuauuauauuacaggcguuacauu
guugucuuuaguucgugcugcaaaguuuuagauuaaguucauaaacgaac
aaaacuccauauauauaauuuuaauuauauauaauuuuauauuauuuauu
aauauaaagaaaggaauuaagacaaucauaaugauccuuauaauaugggu
aauagacgugcuauaauaaaaugauaauaaaauuauauaaaauauauuua
auuauauuuaauuaauaauauaaaacauuuuaauuuuuaauauauuuuuu
uauuauauauuaauaugaauuauaaucugaaauucgauuauaugaaaaaa
gaauugcuaguaauacguaaauuaguauguuacggugaauauucuaacug
uuucgcacuaaucacucaucacgcguugaaacauauuauuaucuuauuau
uuauauaauauuuuuuaauaaauuuauuaauuuauauuuauuuauaucag
aaauaauaugaauuaaugcgaaguugaaauacaguuaccguaggggaacc
ugcggugggcuuauaaauaucuuaaauauucuuaca
....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<
.<<<..<<<..<<<<<<<<<<<<.....>>>>>>>>>>..>>>>>.....
<<<........<<<<<.<<.........<<<<<<<<.<<<<.......>>
>>...........<<<<<<<<.>>>>>>>>.>>>>>>>>....>>>>>>>
<<<....<<<..<<<<<<<<........>>>>>>>>>>>......>>>..
<<<<.<<<<....>>>>...>>>>.>>><<<<<<.........>>>>>><
<<<.....>>>>..>>>>>>.........<<<....<<<<....>>>>..
>>>..>>.>>>>>>.<<<<..<<<<<<........>>>>>>..<<.....
.>>.....>>>>..<<<<<<<<..............>>>>><<<<<<<..
..>>>>>>><<..>>>>>....<<<<<(((.....<<<<.....<<.)))
>>.......>>>>.>>>>>..>>>>>>>>>.....<<<((.....<<<<.
..<.<<.<<<<<<<...>>>>>>>...<<<<<<<<...<<<<<<<<<<..
<<<<<<<...................>>>>>>>..>>.......<<....
>>.>>>>>>>>.>>>>>>>>...>>>...>>>>....<<<<<<...<<..
.<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<
<<<<<<<<<..>>>>>>>>>>>>>..<<..))>>....>>>>>>.>>>.<
<.......<<<<....>>>>.....>>..)))).]<<.<<...<<<<...
.<.<<<<<..<<<<<<<<<<............................<<
<<<<<.....<<.<<<<<<<<<<.>>>>>>>>>>.>>.<<<.<<..<<<<
<<<<<<<<..<<<<<<<<<....>>>....<<......>>....>>>>>>
.....<<<.<<<<<<<<........>>>>>>>>..<<<<<<<<<.....>
>>>>>>>>....>>>...>>>>>>>...>>>>>>>>>>...>>>>>>>..
.>>.>>>>>>>>.....<<<<<<........<<<..<<..<<<<<<....
..>>>>>>..>>....>>>......>>>>>>......<<<<<........
>>>>>..........<....<<<<<<<........>>>>>>>....>...
..>>>>>.....<<.<<<<<.........>>>>>>>.....>.....>>>
>..>>..>>....<.<<<.<.<<<<<<<<..<<<<<<<<<.<<<...<<<
..<<<.<<<<<...<<<<<<<..>>>>>>>...>>>>>>>>..>>>..>>
>>>>>>>>>>..>>>>>>>>..>.>>>..>.....<<<<<<<<<....>>
>>>>>>>.............................
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8om2 METTL17 is an Fe-S cluster checkpoint for mitochondrial translation.
Resolution2.57 Å
Binding residue
(original residue number in PDB)
Y109 I112 Q113 I135 Q138 I287 G312 N313 P314 H391 K392 K398 F399 Q403 R408 K416 K419 L421 A422 T423 S424 W425 R441 N442 G443 R444 Y446 I448 N450 I498 N499 R504 K505 H507 M509 D511 K521 R526 S527 R537 E570 L575 K576 E579 R580 Q581 R584 K585
Binding residue
(residue number reindexed from 1)
Y50 I53 Q54 I76 Q79 I198 G223 N224 P225 H288 K289 K295 F296 Q300 R305 K313 K316 L318 A319 T320 S321 W322 R324 N325 G326 R327 Y329 I331 N333 I381 N382 R387 K388 H390 M392 D394 K404 R409 S410 R420 E453 L458 K459 E462 R463 Q464 R467 K468
Enzymatic activity
Enzyme Commision number 2.1.1.-
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0008168 methyltransferase activity
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006412 translation
GO:0032543 mitochondrial translation
GO:0180026 mitochondrial small ribosomal subunit assembly
Cellular Component
GO:0005739 mitochondrion
GO:0005763 mitochondrial small ribosomal subunit

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8om2, PDBe:8om2, PDBj:8om2
PDBsum8om2
PubMed38199006
UniProtP36056|RT22_YEAST Ribosome assembly protein RSM22, mitochondrial (Gene Name=RSM22)

[Back to BioLiP]