Structure of PDB 8gxs Chain c Binding Site BS01

Receptor Information
>8gxs Chain c (length=263) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VSVNLEAFSQAISAIQALRSSVSRVFDCLKDGMRNKETLEGREKAFIAHF
QDNLHSVNRDLNELERLSNLVLYSQLLQAYKWSNKLQYHAGLASGLLNQQ
SLKRSANQLVLPPQYVDDVISRIDRMFPEMSIHLSRPNGTSAMLLVTLGK
VLKVIVVMRSLFIDRTIVKGYNENVYTEDLDIWSKSNYQVFQKVTDHATT
ALLHYQLPQMPDVVVRSFMTWLRSYIKLFQAPCQRCGKFLQDGLPPTWRD
FRTLEAFHDTCRQ
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8gxs Chain c Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8gxs Structures of +1 nucleosome-bound PIC-Mediator complex.
Resolution4.16 Å
Binding residue
(original residue number in PDB)		C281 H306 C309
Binding residue
(residue number reindexed from 1)		C233 H258 C261
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0016567 protein ubiquitination
GO:0032968 positive regulation of transcription elongation by RNA polymerase II
GO:0035019 somatic stem cell population maintenance
GO:0051123 RNA polymerase II preinitiation complex assembly
GO:0060261 positive regulation of transcription initiation by RNA polymerase II
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0016592 mediator complex
GO:0070847 core mediator complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8gxs, PDBe:8gxs, PDBj:8gxs
PDBsum8gxs
PubMed36201575
UniProtQ6P2C8|MED27_HUMAN Mediator of RNA polymerase II transcription subunit 27 (Gene Name=MED27)

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