Structure of PDB 8a98 Chain c Binding Site BS01

Receptor Information
>8a98 Chain c (length=227) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AAFKQQQTESFKKAVVARKAAKAALKKTAYLRARKYSREYRGAEKKLVTL
RRQAASHGNYYLEAKPKVAVVTRIRGIAKVNPKQRKILQLLRLRQIFNTV
FVKMNKPMENMLRAVEPYIAYGYPSLATVRAMVYKRGYLKINGQRVKITD
NQMIKDKYNNVDIVCAEDMVNQIYTCGKHFRTVTHGMWPFKLAPPAGGMR
QKRRHFVEGGDYGNRDTLINRFLARMI
Ligand information
>8a98 Chain 1 (length=1579) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agaccugaguguggcaggacuacccgccgaacuuaagcauauuacucagc
ggaggaaaagaaaacaaccgugauucucucagugagcggcgagcgaagag
ggaacgaacucguugccgaaucgggucuuacaaggccuuaaguuguggca
caaauaucauuucgugguuggugcaggaguggcgaaauucaagcgcaaag
caaacccguugcugaauacaacccuucaugugaguauugagccaaagaag
guguuagcccauugagccauaaaccugagcgccucaugaacaagcgagua
gcacuguuugggaaugcagugucaaguuggcagguauuugucugccaaag
uuaaauacagaguaggaagaccgauagcgaacaaguagcgugagcgaaag
uuugaaaagcacuuuggaaagagagugaaauagaaccugaagucgugaca
aagacaauggaaguaccuccauuucaagagccagaaccagcccuacugca
uuauccugucgggggucaaaauccggcgggcaacgaagugcaagaggguc
uuggugaaaugagcggaguauuugagcuggcacgggcacgcacucuucuc
cgugaugcuccauguuggcgauggaaauggggugcccccacccgucuuga
aacacggaccaaggagucaaacagacgcgcaagggaggagauauggccag
uacuucucucguacugaaagggagaugcaaaaugcaucuguggugugcac
acgucaaauccguuugauuugcccaacaccgaccggcccuccguggguug
cguuggagugugccuguuuggacccgaaagguggugaacuaugccugaac
aaggugaagcccggggaaacccagguggaggccuguagcgaugcugacgu
gcaaaucgcucguaugauuuggguaucggagcgaaagacucaucgaacca
ccuaguagcugguucacaucgaaguuucccucaggauagcuggugcuagu
agaaguauugugcgguaaagcgauacuuuaaaugugcaaacaaaccggcc
uuagccaacugcaaggccggaaagaaaagaauuagaggcaccaagugggc
cuucuucgguaagcggagcaggcgaugcggaaugaaccgcuuagggauau
guggcgucaaaacuuaugggcucauucucgauacguaaaggguguuggug
gccaccggccccgaaaauggaugacgcuuaaggccaauuagugaaugccc
auuauuccuuugguaagggcggaaacggagaaaguguagcccuuccgaug
uagauguggccuggagguuaggacgaagcuuauggcgugagccuaagaug
gaccggccucuagugcagaucuugguuggcguagcaaagaucuaacggag
auauacucaacaugcaacguuggauacuggagcggggaaggauuucgugc
caacggcacucguacacgaguuguucggaaacugagcacaacguuauauc
guuuuguuaggaaagugaaguacugaaaaggggcaacagagaaccuggga
uuauauuccaaaaagaaauugcauguggg
......................<<<<<......<<....>>.......>>
>>.>.........<<....>>..<<<<<<......<<.....>>....>>
>>>>...<<<...<<<<<..<.<<<<<......>>>>>..>....>>>>>
..........<<<<<<...<<<<<<<<.<<<<<......<<<......<<
<<.......>>>>.....<<........>>......>>>.<<.......(
(.....>>)).....>>>>>...>>>..>>>>>.>>>>>>..........
<<<<<<<........>>>>>>>......<<<<<........>>>>>..>>
>....................................<<....>>.....
...........<<<<....>>>>...........................
.......(((..<<<<<<.<<<<<.....<<<<<.<<<<<<<<<...<<<
<<..<<<<<<<<<........>>>>>>>>>.....>>.>>>...>>>>>.
.>>>>........<<<<<.....<<....<<.<..>...>>..>>..>>>
>>.....<<<<...>>>>>.....>>>>>>>>>>>..))).<<<<.....
...>>>><<<<<<....<<<<<<<.<<<<<..<<<<..<<.<........
.>>>..>>>>...<<....>>..<<<<<.....>>>>>...<<<<<...<
<.<<<<<<....>>>>>>.>>....>>>>><<<<<<<<<.....>>>>>>
.>>>...>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<.
.<<<....<<<.<<<....>>>.>>>.....>>>...<<<<.<<.<<...
.....>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>
>>...>..>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<...
..<<...<<<<<<<...<<<.....>>.>...>>>>>>>.....<<<<<<
<<.<<.....>>>>>>>>>>...........>>...>>>>>>>.>>..<<
<<.<<<<<.....>>>>>.>>>>...<<<<......>>>>..<<<<<<<.
..<<<<<<......[..((.(........(.........<<<.<<<<<<<
..>>>>>>>>>>..........>>>.)....).)).].........>>>.
..>>>>>>>((((.<<<<<.......>>>>.........>>>>>))))..
..>>>>>..<.<<<<<<<<........<<<<..<<<....>>>.>>>.>.
....>>>>>>>>..>.....>>>>>>..............<<<<<<<...
.................>>>>>>>....................<<<<<.
...<<.....>>..>>>>>....<<..........<<.<<<<<......>
>>>...............<....>......>.>>..........<<<<..
.......>>....>>.>>...........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8a98 CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : snoRNA MUTANT
Resolution2.46 Å
Binding residue
(original residue number in PDB)
S35 Y55 R59 R63 G67 K70 R77 H82 R100 G101 I102 K104 N106 P107 K108 K111 I112 L115 R117 Q120 N130 P132 N135 S150 R161 Q169 R170 R206 H210 K216 L217 P219 A221 G222 G223 M224 K227 T242 N245 R246 A249 R250
Binding residue
(residue number reindexed from 1)
S10 Y30 R34 R38 G42 K45 R52 H57 R75 G76 I77 K79 N81 P82 K83 K86 I87 L90 R92 Q95 N105 P107 N110 S125 R136 Q144 R145 R181 H185 K191 L192 P194 A196 G197 G198 M199 K202 T217 N220 R221 A224 R225
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8a98, PDBe:8a98, PDBj:8a98
PDBsum8a98
PubMed38722744
UniProtQ4Q9H4

[Back to BioLiP]