Structure of PDB 7yev Chain c Binding Site BS01

Receptor Information
>7yev Chain c (length=1082) Species: 538123 (Mammalian orthoreovirus 3) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HGYQCHVCSAVLFSPLDLDAHVASHGLHGNRHITEFISSWQNHPIVQVSA
DVENRKTAQLLHADTPRLVTWDAGLCTSFKIVPIVPAQVPQDVLAYTFFT
SSYAIQSPFPEAAVSRIVVHTRWASNVDFDRDSSVIMAPPTENNIHLFKQ
LLNTETLSVRGANPLMFRANVLHMLLEFVLDNLYLNRHTGFSQDHTPFTE
GANLRSLPGPDAEKWYSIMYPTRMGTPNVSKICNFVASCVRNRVGRFDRA
QMMNGAMSEWVDVFETSDALTVSIRGRWMARLARMNINPTEIEWALTECA
QGYVTVTSPYAPSVNRLMPYRISNAERQISQIIRVMNIGNNATVIQPVLQ
DISVLLQRISPLQIDPTIISNTMSTQTLSPASSILGKLRPSNSDFSSFRV
ALAGWLYNGVVTTVIDDSSYPKDGGSVTSLENLWDFFILALALPLTTDPC
APVKAFMTLANMMVGFETIPMDNQIYTQSRRASAFSTPHTWPRCFMNIQL
ISPIDAPILRQWAEIIHRYWPNPSQIRYGTPNVFGSANLFTPPEVLLLPI
DHQPANVTTPTLDFTNELTNWRARVCELMKNLVDNQRYQPGWTQSLVSSM
RGTLGKLKLIKSMTPMYLQQLAPVELAVIAPMLPFPPFQVPYVRLDRDRV
PTMVGVTRQSRDTITQPALSLSTTNTTVGVPLALDARAITVALLSGKYPP
DLVTNVWYADAIYPMYADTEVFSNLQRDVITCEAVQTLVTLVAQISETQY
PVDRYLDWIPSLRASAATAATFAEWVNTSMKTAFDLSDMLLEPLLSGDPR
MTQLAIQYQQYNGRTFNVIPEMPGSVIADCVQLTAEVFNHEYNLFGIARG
DIIIGRVQSTHLWSPLAPPPDLVFDRDTPGVHIFGRDCRISFGMNGAAPM
IRDETGMMVPFEGNWIFPLALWQMNTRYFNQQFDAWIKTGELRIRIEMGA
YPYMLHYYDPRQYANAWNLTSAWLEEITPTSIPSVPFMVPISSDHDISSA
PAVQYIISTEYNDRSLFCTNSSSPQTIAGPDKHIPVERYNILTNPDAPPT
QIQLPEVVDLYNVVTRYAYETPPITAVVMGVP
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7yev Chain c Residue 1301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7yev In situ structures of polymerase complex of mammalian reovirus illuminate RdRp activation and transcription regulation.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		C186 H199 H203
Binding residue
(residue number reindexed from 1)		C8 H21 H25
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006370 7-methylguanosine mRNA capping
Cellular Component
GO:0019028 viral capsid
GO:0039625 viral inner capsid

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7yev, PDBe:7yev, PDBj:7yev
PDBsum7yev
PubMed36469786
UniProtC9E874

[Back to BioLiP]