Structure of PDB 7unr Chain c Binding Site BS01

Receptor Information

>7unr Chain c (length=208) Species: 208964 (Pseudomonas aeruginosa PAO1)

GQKVHPNGIRLGIVKEHTSVWYADRKNYADYLFADLKVREYLQDKLKSAS
VSRIDIHRPAQTARITIHTARPGIVIGKKGEDVEKLRQDLTKQMGVPVHI
NIEEIRKPELDAMLVAQSVAQQLERRVMFRRAMKRAVQNAMRIGAKGIKI
QVSGRLGGAEIARTEWYREGRVPLHTLRADIDYATYEAHTTYGVIGVKVW
IFKGEVIG

Ligand information

>7unr Chain a (length=1522)

gaacugaagaguuugaucauggcucagauugaacgcuggcggcaggccua
acacaugcaagucgagcggaugaagggagcuugcuccuggauucagcggc
ggacgggugaguaaugccuaggaaucugccugguagugggggauaacguc
cggaaacgggcgcuaauaccgcauacguccugagggagaaagugggggau
cuucggaccucacgcuaucagaugagccuaggucggauuagcuaguuggu
gggguaaaggccuaccaaggcgacgauccguaacuggucugagaggauga
ucagucacacuggaacugagacacgguccagacuccuacgggaggcagca
guggggaauauuggacaaugggcgaaagccugauccagccaugccgcgug
ugugaagaaggucuucggauuguaaagcacuuuaaguugggaggaagggc
aguaaguuaauaccuugcuguuuugacguuaccaacagaauaagcaccgg
cuaacuucgugccagcagccgcgguaauacgaagggugcaagcguuaauc
ggaauuacugggcguaaagcgcgcguaggugguucagcaaguuggaugug
aaauccccgggcucaaccugggaacugcauccaaaacuacugagcuagag
uacgguagagggugguggaauuuccuguguagcggugaaaugcguagaua
uaggaaggaacaccaguggcgaaggcgaccaccuggacugauacugacac
ugaggugcgaaagcguggggagcaaacaggauuagauacccugguagucc
acgccguaaacgaugucgacuagccguugggaucgaucuuaguggcgcag
cuaacgcgauaagucgaccgccuggggaguacggccgcaagguuaaaacu
caaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauu
cgaagcaacgcgaagaaccuuaccuggccuugacaugcugagaacuuucc
agagauggauuggugccuucgggaacucagacacaggugcugcauggcug
ucgucagcucgugucgugagauguuggguuaagucccguaacgagcgcaa
cccuuguccuuaguuaccagcaccucgggugggcacucuaaggagacugc
cggugacaaaccggaggaagguggggaugacgucaagucaucauggcccu
uacggccagggcuacacacgugcuacaauggucgguacaaaggguugcca
agccgcgagguggagcuaaucccauaaaaccgaucguaguccggaucgca
gucugcaacucgacugcgugaagucggaaucgcuaguaaucgugaaucag
aaugucacggugaauacguucccgggccuuguacacaccgcccgucacac
caugggaguggguugcuccagaaguagcuagucuaaccgcaagggggacg
guuaccacggagugauucaugacuggggugaagucguaacaagguagccg
uaggggaaccugcggcuggauc

........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<....
.<<<.<<<..<<<..<<.<<....<<<<<<..>>>>>>....>>.>>>>>
......<<.......<<<<<<<..<<...<<<<<<<<<.<<.....<<<<
<<....>>>>>>......>>.>.....<<<....>>>....<<<<<<..<
<....>>>>>>>>>>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<
<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>..
.>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>
>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<
<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<<<<
<<<<<<.......>>>>>>>>>>........>>>>>....>..<<<<<((
(...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>
..........<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<.
.....<<<<<<.....>>>>>>....>>>>>>>>..>>.>>>>>>...<<
<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>
>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>
>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>
>>>>..........<<<<<<..<<<<<<<<<<<..>>>>>>>>>>>...<
<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>
>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......
<<........>>..........<<<<<<<......<<<<<<<......<<
<....>>>.......<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.
......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>....
.<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<
<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>
...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..
.<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<
<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.....
....>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<
<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>
>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<
<<<<....>>>>>>>>>.....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7unr Compact IF2 allows initiator tRNA accommodation into the P site and gates the ribosome to elongation
• Resolution: 2.9 Å
• Binding residue (original residue number in PDB): G2 Q3 K4 V5 R26 R127 S154 R156 E161 A163 R169 R172 V173 P174 H176 T177 L178 R179 E188 Y193 V195
• Binding residue (residue number reindexed from 1): G1 Q2 K3 V4 R25 R126 S153 R155 E160 A162 R168 R171 V172 P173 H175 T176 L177 R178 E187 Y192 V194

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003723 RNA binding
• GO:0003729 mRNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7unr, PDBe:7unr, PDBj:7unr
• PDBsum: 7unr
• UniProt: Q9HWE1|RS3_PSEAE Small ribosomal subunit protein uS3 (Gene Name=rpsC)