Structure of PDB 7of5 Chain c Binding Site BS01

Receptor Information

>7of5 Chain c (length=275) Species: 9606 (Homo sapiens)

VKKGFRAAFRFQKELERQRLLRCPPPPVRRSEKPNWDYHAEIQAFGHRLQ
ENFSLDLLKTAFVNSCYIKSEEAKRQQLKSNQELSEQGTSFSQTCLTQFL
EDEYPDMPTEGIKNLVDFLTGEEVVCHVARNLAVEQLTLSEEFPVPPAVL
QQTFFAVIGALLQSSGPERTALFIRDFLITQMTGKELFEMWKIINPMGLL
VEELKKRNVSAPESRLTRQSGGTTALPLYFVGLYCDKKLIAEGPGETVLV
AEEEAARVALRKLYGFTENRRPWNY

Ligand information

>7of5 Chain A (length=1389)

gcuaaaccuagccccaaaccccaccuuacuaccaaaccuuagccaaacca
uuuacauaaaguauaggcgauagaaauugauggcgcaauagauauaguac
cgcaagggaaagaugaaaaacaagcauaauauagcaaggacuaaccccua
uaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaa
agcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaaagagc
acacccgucuauguagcaaaauagugggaagauuuauagguagaggcgac
aaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguu
caacuuuaaauuugcccacagaacccaaauccccuuguaaauuuaacugu
uaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagag
agaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauua
agaaagcguucaagcucaacacaaaaaucccaaacauauaacugaacucc
ucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuagu
auaaguaacaugaaaacauucuccuccgcauaagccugcgucagcugaca
auuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucac
ugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaa
ggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuag
caucaccaguauuagaggcaccgccuuccuuaaauagggauggcuccacg
aggguucagcugucucuuacuuuuaaccagugaaauugaccugcccguga
agaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauu
uauuaaugcaaacaccugcauuaaaaauuucgguuggggcgaccucggag
cagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcg
aaccucaauugauccaauaacuugaccaacggaacaaguuacccuaggga
uaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgac
cucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguuc
guuuguucaacgauuaaaguccuacgugaucugaguucagaccggaguaa
uccaggucgguuucuaucuacuuuaauuccucccuguacgaaaggacaag
agaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucauc
ucaacuuaguauuauacccacacacccaagaacaggguu

<<<.......<<<<..............................<.....
.>...........<<.....>>.........>>.>>.............<
<....>>...............>>>...........<<<.......>>>.
..<.<........>.>.<<<<<<.........<<<.<<..<<....>>..
.>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<.....>>>
...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<....
...>>......>.>>>>......>.>>..<<<<<<....<<<<....>>>
><<<.<<<<<<<<<<.....<<.......>>.....>>>>>>>>>>..>>
>.<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<
.<<<...<..............<....<<<.........>>>....>...
....<<<......>>>..........................>...>>>>
>>........>>>>>>...<<<<<......>>>>>.........>>>>>>
.......<<..<<<....>>><<<<..<<<<........<<<<..>>>>.
.....<<<...<<<<.......................>>>>.......>
>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<
<.........<......<<<<<<..<<<.........>>>...<<<<<<.
............>>>>>>....<<<.<<<<.....>>>>..>>>....>>
.>>>>.....>..>>.>>>>>>>>>>>>.>>...........<<<<<...
.....>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<
<.<<<<<<<<......>>>>>>>>>>>>>..<<<<.....>>>><<<<<<
...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>.
...>>.........<<<....>>>............>>>>..>>>>>>..
.....<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>
......<<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<
<<<.....>>>>>.....>>>>>..>...>>>.>>>...<<<<<<<....
>>>.>>>>....>>..>>>.>>...<<<.<<<.................>
>>.>>><<<<<...<<<....>>>.>>>>>......<<<...........
.....>>>...............<<<<.......>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7of5 Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling.
• Resolution: 2.9 Å
• Binding residue (original residue number in PDB): V31 K33 F35 R36 F39 F41
• Binding residue (residue number reindexed from 1): V1 K3 F5 R6 F9 F11

Enzymatic activity

• Enzyme Commision number: 3.1.26.-

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003725 double-stranded RNA binding
• GO:0004519 endonuclease activity
• GO:0004525 ribonuclease III activity
• GO:0005515 protein binding

Biological Process

• GO:0006396 RNA processing
• GO:0032543 mitochondrial translation
• GO:0070125 mitochondrial translational elongation

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:0005886 plasma membrane
• GO:0016604 nuclear body
• GO:0070877 microprocessor complex
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7of5, PDBe:7of5, PDBj:7of5
• PDBsum: 7of5
• PubMed: 34135319
• UniProt: Q9H9J2|RM44_HUMAN Large ribosomal subunit protein mL44 (Gene Name=MRPL44)