Structure of PDB 7m4u Chain c Binding Site BS01

Receptor Information

>7m4u Chain c (length=215) Species: 480119 (Acinetobacter baumannii AB0057)

GQKVHPIGIRLGVVKRHNANWYANPKQYAEYLLKDLQVREFLTKKLKNAM
VSNILIERPSGAAKVTISTARPGIVIGKKGEDIEKLQRELTNIMGVPAQV
SINEIDRPDLDARLVAEAIASQLEKRVMFRRAMKRAVQNTMRAGAKGIKV
EVSGRLGGAEIARTEWYREGRVPLHTLRADIDYATMRAETTYGTIGVKVW
IFRGEILGGMKQVMN

Ligand information

>7m4u Chain a (length=1528)

uaacugaagaguuugaucauggcucagauugaacgcuggcggcaggcuua
acacaugcaagucgagcgggggaagguagcuugcuaccggaccuagcggc
ggacgggugaguaaugcuuaggaaucugccuauuagugggggacaacauc
ucgaaagggaugcuaauaccgcauacguccuacgggagaaagcaggggau
cuucggaccuugcgcuaauagaugagccuaagucggauuagcuaguuggu
gggguaaaggccuaccaaggcgacgaucuguagcgggucugagaggauga
uccgccacacugggacugagacacggcccagacuccuacgggaggcagca
guggggaauauuggacaauggggggaacccugauccagccaugccgcgug
ugugaagaaggccuuaugguuguaaagcacuuuaagcgaggaggaggcua
cucuaguuaauaccuagggauaguggacguuacucgcagaauaagcaccg
gcuaacucugugccagcagccgcgguaauacagagggugcgagcguuaau
cggauuuacugggcguaaagcgugcguaggcggcuuauuaagucggaugu
gaaauccccgagcuuaacuugggaauugcauucgauacuggugagcuaga
guaugggagaggaugguagaauuccagguguagcggugaaaugcguagag
aucuggaggaauaccgauggcgaaggcagccaucuggccuaauacugacg
cugagguacgaaagcauggggagcaaacaggauuagauacccugguaguc
caugccguaaacgaugucuacuagccguuggggccuuugaggcuuuagug
gcgcagcuaacgcgauaaguagaccgccuggggaguacggucgcaagacu
aaaacucaaaugaauugacgggggcccgcacaagcgguggagcauguggu
uuaauucgaugcaacgcgaagaaccuuaccuggccuugacauacuagaaa
cuuuucagagauggauuggugccuucgggaaccuagauacaggugcugca
uggcugucgucagcucgugucgugagauguuggguuaagucccgcaacga
gcgcaacccuuuuccuuacuugccagcauuucggaugggaacuuuaagga
uacugccagugacaaacuggaggaaggcggggacgacgucaagucaucau
ggcccuuacggccagggcuacacacgugcuacaauggucgguacaaaggg
uugcuacacagcgaugugaugcuaaucucaaaaagccgaucguaguccgg
auuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucgcg
gaucagaaugccgcggugaauacguucccgggccuuguacacaccgcccg
ucacaccaugggaguuuguugcaccagaaguagcuagccuaacugcaaag
agggcgguuaccacgguguggccgaugacuggggugaagucguaacaagg
uagccguaggggaaccugcggcuggauc

........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<....
.<<<.<<<..<<<..<<.<<<...<<<<<<..>>>>>>...>>>.>>>>>
......<<.......<<<<<<<..<<...<<<<<<<<<.<<.....<<<<
<<....>>>>>>......>>.>.....<<<....>>>....<<<<<<..<
<....>>>>>>>>>>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<
<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>..
.>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>
>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<
<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<<<
<<<<<<.......>>>>>>.>>>>........>>>>>....>..<<<<<(
((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>
>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<
......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<
<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......
>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>
>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>
>>>>>..........<<<<<<..<<<<<<<<<<<<<...>>>>>>>>>>>
>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>
....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<
......<<........>>..........<<<<<<<......<<<<<<...
<..<<<<....>>>>..>...<<....>>...>>>>.>>.<<<.<<<..<
<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>
>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>
.....<<<<<.....>>>>>........>>>>.........>>>...>>>
>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<
..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<..
..<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<
<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<
.<.<<<<.<<<..<<<.<<<<<<<<....<<<<<<.<<<<..<<....>>
.>>>>>>>>>>...>>>>>>>>.>>>..>>>.>>>>..>.>>...>....
.<<<<<<<<<....>>>>>>>>>.....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7m4u Cryo-EM Determination of Eravacycline-Bound Structures of the Ribosome and the Multidrug Efflux Pump AdeJ of Acinetobacter baumannii.
• Resolution: 2.71 Å
• Binding residue (original residue number in PDB): G2 Q3 K4 V5 I10 S154 R156 G159 E161 A163 R169 R172 V173 P174 L175 H176 T177 L178 R179 R188 Y193 T195 K199
• Binding residue (residue number reindexed from 1): G1 Q2 K3 V4 I9 S153 R155 G158 E160 A162 R168 R171 V172 P173 L174 H175 T176 L177 R178 R187 Y192 T194 K198

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003723 RNA binding
• GO:0003729 mRNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7m4u, PDBe:7m4u, PDBj:7m4u
• PDBsum: 7m4u
• PubMed: 34044590
• UniProt: B7IA33|RS3_ACIB5 Small ribosomal subunit protein uS3 (Gene Name=rpsC)