Structure of PDB 7a5h Chain c Binding Site BS01

Receptor Information
>7a5h Chain c (length=275) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VKKGFRAAFRFQKELERQRLLRCPPPPVRRSEKPNWDYHAEIQAFGHRLQ
ENFSLDLLKTAFVNSCYIKSEEAKRQQLKSNQELSEQGTSFSQTCLTQFL
EDEYPDMPTEGIKNLVDFLTGEEVVCHVARNLAVEQLTLSEEFPVPPAVL
QQTFFAVIGALLQSSGPERTALFIRDFLITQMTGKELFEMWKIINPMGLL
VEELKKRNVSAPESRLTRQSGGTTALPLYFVGLYCDKKLIAEGPGETVLV
AEEEAARVALRKLYGFTENRRPWNY
Ligand information
>7a5h Chain A (length=1457) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcuaaaccuagccccaaacccccaccuuacuaccaaaccuuagccaaacc
auuuacauaaaguauaggcgauagaaauugggcgcaauagauauaguacc
gcaagggaaagaugaaaaaaccaagcauaauauagcaaggacuaaccccu
auaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagcca
aagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaagagca
cacccgucuauguagcaaaauagugggaagauuuauagguagaggcgaca
aaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguuc
aacuuuaaauuugcccacagaaccaaauccccuuguaaauuuaacuguua
guccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagag
aguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaag
aaagcguucaagcucaacacaaaaaucccaaacauauaacugaacuccuc
acacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguau
aaguaacaugaaaacauucuccuccgcauaagccugcgucagcaacugac
aauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccuca
cugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaa
aggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucua
gcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacgg
ccgcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaaau
agggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuua
accagugaaauugaccugcccgugaagaggcgggcauaacacagcaagac
gagaagacccuauggagcuuuaauuuauuaaugcaaacaccugcauuaaa
aauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguaca
ugcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuuga
ccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagagu
ccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccg
auggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccuac
gugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuua
uuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcg
ccuucccccguaaaugauaucaucucaacuuagauacccacacccaagaa
caggguu
<<<.......<<<<...............................<....
..>...........<<.....>>.......>>.>>.............<<
....>>.................>>>...........<<<.......>>>
...<.<........>.>.<<<<<<.........<<<.<<..<<....>>.
..>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<...>>>.
..<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.....
..>>......>.>>>>......>.>>..<<<<<<....<<<<....>>>>
<<<.<<<<<<<<<<.....<<......>>.....>>>>>>>>>>..>>>.
<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<
<<...<...................<<<.........>>>..........
..<<<......>>>..........................>...>>>>>>
........>>>>>>...<<<<<......>>>>>.........>>>>>><.
.....<<..<<<....>>><<<<..<<<<........<<<<<...>>>>>
......<<<...<<<<.......................>>>>.......
>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.
<<.........<......<<<<<<..<<<.........>>>...<<<<<<
.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>
><<<<..........>>>>........<...........<<<<<<.....
>>>>>>.....>....>>>....>>.>>>>.....>..>>.>>>>>>>>>
>>>.>>.....>.....<<<<<........>>>>>.......<<..<<<.
<<......<<<<.<<<<<<..<<<<<.<<<<<<<<......>>>>>>>>>
>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<....
.<<<..<<<<.....>>>>..>>>....>>.........<<<....>>>.
...........>>>>..>>>>>>.......<<<..<.<<<<<<...<<..
.....>>...>>>>>>...>.>>.>.......<<<<<..<<<<<..<<.<
<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..
....>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>..<
<<.<<<.................>>>.>>><<<<<...<<<....>>>.>
>>>>......<<<................>>>.........<<<<.....
..>>>>.
Receptor-Ligand Complex Structure
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PDB7a5h Elongational stalling activates mitoribosome-associated quality control.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		V31 K33 G34 F35 R36 F39 L45 R49
Binding residue
(residue number reindexed from 1)		V1 K3 G4 F5 R6 F9 L15 R19
Enzymatic activity
Enzyme Commision number 3.1.26.-
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0004519 endonuclease activity
GO:0004525 ribonuclease III activity
GO:0005515 protein binding
Biological Process
GO:0006396 RNA processing
GO:0032543 mitochondrial translation
GO:0070125 mitochondrial translational elongation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:0005886 plasma membrane
GO:0016604 nuclear body
GO:0070877 microprocessor complex
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7a5h, PDBe:7a5h, PDBj:7a5h
PDBsum7a5h
PubMed33243891
UniProtQ9H9J2|RM44_HUMAN Large ribosomal subunit protein mL44 (Gene Name=MRPL44)

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