Structure of PDB 6y7c Chain c Binding Site BS01

Receptor Information

>6y7c Chain c (length=63) Species: 559292 (Saccharomyces cerevisiae S288C)

TPVTLAKVIKVLGRTGSRGGVTQVRVEFLEDTSRTIVRNVKGPVRENDIL
VLMESEREARRLR

Ligand information

>6y7c Chain 2 (length=1735)

uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcuca
uuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacu
gugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaaga
gauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauuc
auaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaa
auuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuu
caacggguaacggggaauaaggguucgauuccggagagggagccugagaa
acggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccu
aauucagggagguagugacaauaaauaacgauacagggcccauucggguc
uuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauugga
gggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguau
auuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguu
ggccggucggauuuccaacggggccuuuccuucuggcuaaccaggacuuu
uacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauau
uagcauggaauaauagaauaggacguuugguucuauuuuguugguuucua
ggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauu
gucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagca
uuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaag
augaucagauaccgucguagucuuaaccauaaacuaugccgacuagggau
cgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaag
ucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaau
ugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaa
cacggggaaacucaccagguccagacacaauaaggauugacagauugaga
gcucuuucuugauuuugugggugguggugcauggccguucuuaguugguu
uugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauagug
gugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaa
gccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguuc
ugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggcc
gagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcau
uguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucag
cuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuagua
ccgauugaauggcuuagugaggccucaggaucugcuuagagaucucagag
cggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaaca
agguuuccguaggugaaccugcggaaggaucauua

...<<<<......[[.>>>><<<<.<<<<<<...<.<...<......<<<
.<<<..<<....<<....<............>...>>.>>......<<..
......<<<..<<..<<....<<<..................<.....<<
.<<<.....>>>.>>......>.........<<<<<..<<....>>..>>
>>><...<<<<<<......((((((................<<......>
>>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>
>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>..
....>>>...<<<.<<.<....>.>>....>>>.>>.<<.<<<.......
...>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<
.....>>>..>>>..>....>.>.....<<<.<<<<<<<<......>>>>
>>>>..>>>......<<.................>>.........<<<<<
((......<<<<.....<...)).>.......>>>>.>>>>>..>>>>>>
>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<
<<............>>>>>>.>>>>>.......<<<....>>>......<
<<<<.<<.......<<...<.......>..<<<.....>>>....>>...
...>>.>>..>>>..............<<<<.<<.......))))))..>
>.>>>>.........>>....<<<.<<.<<...<<<<..<<..<<<<<<.
....<<........>>........>>>>>>..>>......<<<....>>>
..>>>>..>>.>>..>>>...>>>...>>.>....<<<<<<..<.<...<
<<<.........>>>>...>>>>>>>>..........<<<..<.<<<..<
<<<<<<..<<..........>>.>>>>>>>..>>>...<<..]]>>...>
......>>>.>>>.<<<......<<<<....>>>>....>>>..]]....
...<<.<<<<<<<..<<..<<<....<<<.<<<<<<..............
..............<<<<<......<<.<<...........<<<......
..>>.>........>>.>>..........<<<..<<.<......<<.<<.
....................>>.>>.....<<<<........<<..<<<<
<.<<<<<<....>>>>>>...>>>>>..>>...........<<<<.....
>>>>..........>>>>.....>..>>...>>>..............>>
>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<......
..........>>....>>.......>>>>>>>...........<<<<<<.
.........>>>>>>............>>>......<<<<<<<.......
>>>>>>>.......>>...>>>>>>>>>.....<<<....<....<<<<.
<<..<<<<<<<<<<.<<<..<.<<..<...<<<<<<............>>
>>>>...>..>>.>..>>>.>>>>>>>>>>.>>.>>>>.....>......
.>>>.<<<<<<<<....>>>>>>>>..........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6y7c Good Vibrations: Structural Remodeling of Maturing Yeast Pre-40S Ribosomal Particles Followed by Cryo-Electron Microscopy.
• Resolution: 3.8 Å
• Binding residue (original residue number in PDB): R18 S21 R22
• Binding residue (residue number reindexed from 1): R14 S17 R18

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0000028 ribosomal small subunit assembly
• GO:0000054 ribosomal subunit export from nucleus
• GO:0006412 translation
• GO:0030490 maturation of SSU-rRNA
• GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6y7c, PDBe:6y7c, PDBj:6y7c
• PDBsum: 6y7c
• PubMed: 32138239
• UniProt: Q3E7X9|RS28A_YEAST Small ribosomal subunit protein eS28A (Gene Name=RPS28A)