Structure of PDB 5mrc Chain c Binding Site BS01

Receptor Information

>5mrc Chain c (length=119) Species: 4932 (Saccharomyces cerevisiae)

GGLLWKIPWRMSTHQKTRQRERLRNVDQVIKQLTLGLHVQRCQDKGLTYQ
EAMESKKKYKPRSKSLRLLNKPSVFPKENQMSSKDKYWTFDKKAVGYRKG
IHKVPKWTKISIRKAPKFF

Ligand information

>5mrc Chain A (length=2709)

guagaauaauagauuugaaauauuuauuauauagauuuaaagagauaauc
auggaguauaauaauuaaauuuaauuuaauauaacuauuaauagaagguu
acuaauaaauuaauaauuaauuuuaaaaccuaaagguaaaccuuuauauu
aauaauguuaugaauaauuauuaauaauaauaaacuaagugaacugaaac
aucuaaguaacuuaaggauaagaaaucaacagagauauuaugaguauugg
ugagagaaaauaauaaaggucuaauaaguauuaugugaaaaaaauguaag
aaaauaggauaacaaauucuaagacuaaauacuauuaauaaguauaguaa
guaccguaagggaaaguaugaaaaugauuauuuuauaagcaaucaugaau
auauuauauuauauuaaugauguaccuuuuguauaaugggucagcaagua
auuaauauuaguaaaacaauaaguuauaaauaaauagaauaauauauaua
uauaaaaaaauauauauuuaauuaauauuaauugacccgaaagcaaacga
ucuaacuaugauaagauggauaaacgaucgaacagguugauguugcaaua
ucaucugauuaauugugguuaguagugaaagacaaaucugguuugcagau
agcugguuuucuaugaaauauauguaaguauagccuuuauaaauaauaau
uauuauauaauauauuauauaaagaaugguacagcaauuaauauauauua
gggaacuaguuuuuuaauaauauuaaaucucgaaauauuuaauuauauau
aauaaagagucagauuaugugcgauaagguaaauaaucuaaagggaaaca
gcccagauuaagauauaaaguuccuaauaaauaauaagugaaauaaauau
uaaaauaaauauuuaaaaucaaauauauauauauuuguuaauagauaaua
uacggaucuuaauaauaagaauuauuuaauuccuuggaauauuauauuuu
aaaauauaaauacugaauaucuaaauauuauuauuauaauaauaauaaua
ugguaauagaacauuuaaugauaauauauauuaguuauuaauuaauauau
guauuaauuaaauagagaaugcugacaugaguaacgaaaaaaagguauaa
accuuuucaccuaaaacauaagguuuaacuauaaaaguacggccccuaau
uaaauuaaauauaaauauauuuaagaugggauaaucuauauuaauauuua
ucuuaaaauauauaauuauauuauauauuauauauuuauauaauauaaac
uaauaaagaucaggaaaauuaauguauaccguaauguagaccgacucagg
uauguaaguagagaauaugaaggugaauuagauaauuaaagggaaggaac
ucggcaaagauagcucauaaguuagucaauaaagaguaauaagaacaaag
uuguacaacuguuuacuaaaaacaccgcacuuugcagaaacgauaaguuu
aaguauaaggugugaacucugcuccaugcuuaauauauaaauaaaauuau
uuaacgauaauuuaauuaaauuuagguaaauagcagccuuauuaugaggg
uuauaauguagcgaaauuccuuggccuauaauugaggucccgcaugaaug
acguaaugauacaacaacugucuccccuuuaagcuaagugaaauugaaau
cguagugaagaugcuauguaccuucagcaagacggaaagacccuaugcag
cuuuacuguaauuagauagaucgaauuauuguuuauuauauauaaugaua
auucuaaucuuauacuuaauucuuaaguaauauauaauauauauauauau
uauauauuauaagagacaaucucuaauugguaguuuugauggucauuauc
agcaaaaguaucugaauaaguccauaaauaaauauauaaaauuauugaaa
aaaauaauauauauuauauauauuaauuauaaauugaaauauguuuaauu
gaauauauuuuaguaauagauaaaaauauguacaguaaaauuguaaggaa
aacaauaauaacuuucucggaaagaauuaaauuaauauaaugguauaacu
gugcgauaauuguaacacaaacgagugaaacaaguacguaaguauggcau
aaugaacaaauaacacugauuguaaagguuauugauaacgaauaaaaguu
acgcuagggaaggguaauauagcgaaagaguagauauuguaagcuauguu
ugccaccuucgacucaacauuuccucuugguuguaaaagcuaagaagggu
uugacuguucgucaauuaaaauguuacgugaguuggguuaaauacgaugu
gaaucaguaugguuccuaucugcugaaggaaauauuaucaaauuaaaucu
cauuauuaguacgcaaggaccauaaugaaucaacccaugguguaucuauu
gauaauaauauaauauauuuauuaauauauuaucuauauuaguuuauauu
uuaauuauuaucauaguagauaagcuaaguugauaauaaauaaauauuga
auacauauuaaauaugaaguuguuuuaauaagauaauuaaucugauaauu
uuauacuaaaauuaauaauuauagguuuuauauauuauuuauaauuauaa
uauuaauaaaauacuaauuuaucaguuaucuauauaauaucuaaucuauu
auucuauau

<<<<<<<<<<<<<<<.<<......<<<<<<<<<<<<.....<<<<<<<<<
<<...<<<<....<<<<<<<<.>>>>>>>>...<<<<<<<<<<..<<<<.
......<<<<<<<...>>>>>>>....>>>>..<<<....>>>....<<<
<<<<<<..<....>..>>>>>>>>>.........<<<<<<.....<<...
.>>......>>>>>.>..<<.....<<....>>..<<<<<<.....<<..
...>>....>>>>>>...<<<.........<<<<<<.......>>>>>>.
.....<<<<..((((.>>>>..>>>....>>.>>>>>>>>.>>.......
...<<....>>....>>>>....>>>>>>>>>>>.......<<<<<.<<<
<<<......>>>>>>.>>>>>...<.<........>.>.<<<<<<....<
<<<<<<<<<<<<..<<<.....>>>....................<<<<.
<......>.>>>>.......>>>>>>>>>>>>>..<<.<..<<<<<<<..
..<<<<<<<<<<..<<<<......>.>>>...<<<..<<<<........>
>>>.>>>....>>>>>>>>>>...<<.....>>.......>>>>>>...>
..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<..<..<<<<<
<<<<<<<<<<<..>>>>>>>>>..<<<<...<<<...<<<<<<<.<<<<<
<<<<<<<>>>>>>>>>>>>>>>>>>>..>>.>...>>>>>>>>>>>...>
.>>>>>>.>>..<<<<<<.<<<......>>>.>>>>>>....<<<.....
.>>>...<<<.<<<<...<<<(((...<<<<<<<.....<<......<<<
<<<<<<<..>>>>>.....<<<<<<<<..>>>>>>>>.>>>>>.......
...)))>>.............>>>>>>><<<<<..>>>>>.<<<<<<<<.
.>>>>>>>>..>>>...>>>>>>><<<<<<<<<<<<...>>>>>>>>>>>
>....>>>>>>..<<<<<<......<<<<<<<<<<<...>>>>>>>>>>>
......>>>>>>........>>>>>><......<<....<<<<<<.....
.>>>>>><<<<<...<<<<<.<.............((..<<<.<<<...<
<<...<..<<<<..>>>>>..>>>...>>>.....)).<<<<<<<.<<<.
....<<.<<<......>>>.>>.<<<<<<<<<<<..>>>>>>>>>.[[..
>>....>>>........>>>>>>>....>>>...>.....<<......>>
>>>>>..<<<.....>>>..>>>>>..<<<<....<<<<<<<<.<<....
.............<<<....<.....>......>>>.............<
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......>>>>>>>..<<<<.<<<..<<<<<<<<.<<.....<.<<<<<<<
<....>>>>>>>>>.....>>>>>>>>..>>>>><<<<<........>>>
>>........<...........<<<<<.......>>>>>.....>....>
>.>>..>>.>>>>>>......>>.>>>>>>>>.>>>>>>.....>.....
<<<<<........>>>>>..<<<<<<<<.<<<.<<<....<<<<<.<<<<
<<..<<<<.<<<<<<<..<<<.<<<<<<<<<<<.<<.....>>>>>>>>>
>>>>...<<<<<<<<<.<....>.>.>>.<<<<<<<<<<<<<..>>>>>>
>>>>>>>.>>>>>>....>>>>>>>>>>..>>>>..<<<<.>>>><<<<<
<...........>>>.>>>..<<....<<<.....<<<....>>>.....
.....<<<<<<<.....>>>>>>>...>>>.....<<<<<<<<<<<....
>>>>>>>>>>>.................<<<<<<<....<<<<<......
.>>>>><<<..<<<<<<.>>>>>>.>>>......<<.[.(((>>....>>
>>>>>....<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))
].......<<<<<<.<<..))))..>>>>>>>>.............>>>>
..>>>>>>>..<<<<.<.<<<<<....<<.......>>....>>>>>...
>>>>.>..<<<<<..<<<<<..<<<<<<<<<.......>>>>>>>..>>.
<<<<<.....>>>>>.....>>>>>......>>>.>>....<<<<<<<..
..>>>.>>>>...>>>..>>>>>>>>>>>.....<<<<<..<<<<<<..<
<<<<<<...............>>>>>>><<<<<<....<<<..<<<<<<<
<<<<<<<<.<<<<<<<<<<....>>>>>>>>>>..<<<<...]].>>>>.
....>>>>>>>>>..>>>>>>..>>>..>>>>>>..<<<.<..<<<<<..
..........>>>>>...>>>>.>>>>>>..>>>>>.....<<<<<<<<<
<.......>>>>>........<<<<<<<<<<..<<...<<<<<..>>>>>
.>>..>>>>>>>.>>>....>>>>>..>>>>>>>>>>>>>>.>>>>>>>>
>>>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5mrc The structure of the yeast mitochondrial ribosome.
• Resolution: 3.25 Å
• Binding residue (original residue number in PDB): G13 G14 L15 L16 W17 K18 P20 W21 R22 S24 H26 Q27 K28 R30 R32 R34 R53 K57 K69 Y71 K72 R74 S75 K76 R79 L80 K83 S85 Q92 S94 S95 K98 Y99 K104 K105 K111 P117 K118 T120 K121
• Binding residue (residue number reindexed from 1): G1 G2 L3 L4 W5 K6 P8 W9 R10 S12 H14 Q15 K16 R18 R20 R22 R41 K45 K57 Y59 K60 R62 S63 K64 R67 L68 K71 S73 Q80 S82 S83 K86 Y87 K92 K93 K99 P105 K106 T108 K109

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:5mrc, PDBe:5mrc, PDBj:5mrc
• PDBsum: 5mrc
• PubMed: 28154081
• UniProt: P14063|RM31_YEAST Large ribosomal subunit protein mL60 (Gene Name=MRPL31)