Structure of PDB 6hcj Chain b3 Binding Site BS01

Receptor Information
>6hcj Chain b3 (length=104) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AKSKNHTTHNQSRKWHRNGIKKPRSQRYESLKGVDPKFLRNMRFAKKHNK
KGLKKMQANNAKAMAARAEAIKALVVSRKLHRLAYIAHPKLGRRARARIA
RGLR
Ligand information
>6hcj Chain 51 (length=3635) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuaguc
agcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaac
agggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaau
guggcguacggaagacccacuccccggcgccggggggcccaaguccuucu
gaucgaggcccagcccguggacggugugaggccgguagcggcccccggcg
cgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaa
agcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauag
ucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguuc
aagagggcgugaaaccguuaagagguaaacgggugggguccgcgcagucc
gcccggaggauucaacccggcggcgcgguccggccgugccggcggggcgg
aucucccgcucccgucggcgggggaccgccccccggccggcgaccggccg
ccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggac
ggcugggaaggccccggcggggaagguggcccgggggccccggguguuac
agccccgccccggcagcagcagcucgccgaaucccggggccgagggagcg
agacccgugcgccgcgcucuccccccucgggggggccgggccaccccucc
cacggcgcgaccgcucucccacccggggggcggggcggacuguccccagu
gcgccccgggcgggucgcgccgucgggcccgggggagguucucucggggc
cacgcgucccccgcgagcgcacggggucggcggcgaugucggcuacccac
ccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucg
ggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcggcgcg
ccgccggccgaggugggaucccgaggccuuccaguccgccgagggcgcac
caccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacg
uguuaggacccgaaagauggugaacuaugccugggcagggcgaagccaga
ggaaacucugguggagguccguagcgguccugacgugcgaaucggucguc
cgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguu
cccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccg
guaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauuc
ucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcg
uggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcug
cgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucag
accccagaaaagguguugguugauauagacagcaggaugguggccaugga
agucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacua
gcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgc
uggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgac
gaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccgg
guggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaac
gagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguug
aacaugggucagucgguccugagagaugggcgagcgccguuccgaaggga
cgggcgauggccuccguugcccucagccgaucgaaagggagucggguuca
gauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugc
gguaacgcgaccgaucccggagaagccggcgggagccccggggagaguuc
ucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagag
aggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagc
ucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgg
gccguacccauauccgcagcaggucuccaaggugaacagccucuggcaug
uuggaacaauguagguaagggaagucggcaagccggauccguaacuucgg
gauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggac
caggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcgg
cggguguugacgcgaugugauuucugcccagugcucugaaugucaaagug
aagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucu
uaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggau
gaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaa
gggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuug
acucuagucuggcacggugaagagacaugagagguguagaauaaguggga
ggcccgggccgccggugaaauaccacuacucugaucguuuuuucacugac
ccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcc
cggccggccgggcgcgacccgcuccggggacagugccagguggggaguuu
gacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgag
cucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuu
gaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgau
ccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccaca
gggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuug
auccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagc
guuggauuguucacccacuaauagggaacgugagcuggguuuagaccguc
gugagacagguuaguuuuacccuacugaugauguguuguugccaugguaa
uccugcucaguacgagaggaaccgcagguucagacauuugguguaugugc
uuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacug
aacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagcc
ucgguuggccucggauagccggucccccgcccgggguccggugcggagag
cccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcc
cgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguaga
cgaccugcuucugggucgggguuucguacguagcagagcagcugcugcga
ucuauugaaagucagcccucgacacaaggguuugu
.........................<<<<<<.....<......>......
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....>>>>.............<<<.......>>>...>.>>>>>>>...>
>>..>>>...>>>>.>>>>.......<<<<<<<........>>>>>>>..
....<<<<..(((((.>>>>...>>>........................
..........<<....>>...............<<<......>>>.....
.............................<<<<<<<<..<<..<....<<
<<<<<<.........<<<<<<<<<<....<<<<<<<.<<....<<<<<<<
.<<<<<<<<<......>>>>>>>>>>>>>>>>...>>>>>>...>>>.>>
>>>>>>>>..........>>>.>>>>>...<<<<<<<.<<<<<<<<<<.<
<<<.........<..<<<<<<.......<<<<.<<<.>>>.>>>>.....
...>>>>>>...>............>>>>...>>>>>>>>>>.....<<.
......>>.............<<<<<<..>>>>>>...<.<<.<<<<.<<
<<<<<...<<<<<<....<..<<...>>>.<<<<<<<...<<....>>..
.>>>>>>>.>>.>>>>...>>>>.>>>...>.>>>...........>>.>
..........................>>.>>>>>....>.>>...>>>>>
>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<.
..<<<.......>>>.....>>>...<<....>>...<<<<<<<<<<..>
>>>>>>>>>..<<<<<...<<<..<<........[...>>..>>>....>
>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>
>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<...<<.......<<.
<.....>>>........>>....<<<..<..<<........>>.>.>>>.
...>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..
<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<<.
...<<<....<<<...<<<<..<<<.<<.........>.>>>>>>>.>..
>>>...>>>....>>>>>>...<<<<<<<<<.<......>>>>>>>>>>.
...>>>>>>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....
<<<......>>>...<<<<<<<...<<.(((.......<<<<<.....<<
..........<<<.<<<..<<<.....................<<.....
....>>...............<<......>>.............>>>..>
>>>>>..........))).>>...>>>>>...>>...>>>>>>><<<<<.
.<<<.....................]................>>>.>>>>
>....>>>>>>..<<<<<<<<..<<......<<<<.<<<<....>>>>>>
>>...>>.>>>>>>>.>......>>>>>><<<....<<.....<<<<<<.
......>>>>>>.<<......<<.<..<<...<<<<<<...<<.....>>
.>>>>>>....(.<<<<<<...<<....<<<....>>>............
.<<<<<.<<<...>>>.>>>>>........>>....>>>...<<<<....
....>>>>..)<<<<....<<<......<<<<<......>>>>>....<<
<....>>>......<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..[
[[..>>>>>>.....<<<..<<<<.<<<<.....<<<.....>>>.....
>>>>>>>>...>>>......<<<<<<<.......>>>>>>>>>>>.>.>>
>>>>>>>>>>.........>>>>>>>................>>>.>>>>
.>>>..>>.....<<......>>.>.>>.<<<<.....>>>>...>>...
.<<<<.....<<<<<<..<<...............<<<<<..........
.....>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>.........
...<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<....
.>>>>......>>>>>>>..<.<..<<<..<<<<<.....<<<......<
<<....>>>......>>>..>>>..>>>>><..<<.........>>...>
.......<...........<<<<<.......>>>>>.....>.....>..
>..>>.>>>>>>>.....>>..>>>>>>..>>>>>>...>>>....<<<<
<........>>>>>.....<<<<..<<<.<<......<<<<....<<<..
<<<<..<<<<<<<<..<<<.<<<<...<.<<<<..........<<<<<..
.<<<..>>>.............>>>>>.>>>>.>...>.>>.>>>>...<
<<<<.....<<<<.................................<<<<
<.<<..>>.>>>>>...>>>>..>>>>>.....>>>>>>>>...>>>>..
..<<.....>>...<<<<<<...........>>>>>>..<<...<<<<<<
<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>.
..<<.<<<<<<.......>>>>.>>>>.<<<....>>>.>>)))].....
.<<<<<<..<<<...))))).>>>>>>>>>..........>>>.....>>
>>.......<<..<<.<<<<<<...<<.......>>...>>>>>>...>>
.>.>.........<<<.<.<<<...<...<<<<<......>>>>>.....
>.<<<.........>>>......>>>...>...>>>.......<<<<<<<
....>>>.>>>>....>>..>>>.>>>>......<.<<<<....<<<..<
.<<<<<.................>>>>>.><<<<....<<<<....<<..
<.<<<.]]]..>>>....>.>>...>>>>...>>>><<<.....<<<<..
...........>>>>.....>>>.>>>.....>>>>.>.<<<<<<<..<<
<.....<<.........<<<<<....<<<..>>>...>>>>>........
>>...<<<..<<<<....<<<.<<<<<........>>>>>..>>>...>>
>>..>>>...............>>>..>>.>>>>>.<<<<<.<.......
......>....<<.<<<<<<<.<<.....<<<<.<..<<<<<.>>>>>..
>>>>>....>>....>>>>.>>>.>>..>>>>>..
Receptor-Ligand Complex Structure
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PDB6hcj ZNF598 Is a Quality Control Sensor of Collided Ribosomes.
Resolution3.8 Å
Binding residue
(original residue number in PDB)
A2 K3 K5 N6 H7 T8 T9 H10 Q12 S13 R14 K15 H17 R18 R28 Y29 F39 R41 N42 M43 R44 F45 K47 K48 H49 K52 M57 N60 M65 R91 H101 K103 R106 R111 A113 R114 G115 L116 R117
Binding residue
(residue number reindexed from 1)
A1 K2 K4 N5 H6 T7 T8 H9 Q11 S12 R13 K14 H16 R17 R27 Y28 F38 R40 N41 M42 R43 F44 K46 K47 H48 K51 M56 N59 M64 R78 H88 K90 R93 R98 A100 R101 G102 L103 R104
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:6hcj, PDBe:6hcj, PDBj:6hcj
PDBsum6hcj
PubMed30293783
UniProtG1SGR6|RL29_RABIT Large ribosomal subunit protein eL29 (Gene Name=RPL29)

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