Structure of PDB 7r81 Chain b1 Binding Site BS01

Receptor Information
>7r81 Chain b1 (length=135) Species: 5141 (Neurospora crassa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKFLKTSRVCLVTRGRYAGKKVVIIQPVDNGSKTHPYGHAIVAGIERYPS
KITRRMSKTRQEKRSKVKPFIKVINYNHLMPTRYTLELEGLKGSVSAETF
KEVSQREDAKKTVKKVLEERYTSGKNRWFFTPLRF
Ligand information
>7r81 Chain A1 (length=3123) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uugaccucggaucagguaggaauacccgcugaacuuaagcauaucaauaa
gcggaggaaaagaaaccaacagggauugcccuaguaacggcgagugaagc
ggcaacagcucaaauuugaaaucuggcuucggcccgaguuguaauuugua
gaggaagcuuuuggugaggcaccuucugaguccccuggaacggggcgcca
uagagggugagagccccguauagucggaugccgauccaauguaaagcucc
uucgacgagucgaguaguuugggaaugcugcucaaaaugggagguaaauu
ucuucuaaagcuaaauaccggccagagaccgauagcgcacaaguagagug
aucgaaagaugaaaagcacuuugaaaagaggguuaaauagcacgugaaau
uguugaaagggaagcguuugugaccagacuugcgccguuccgaucauccg
guguucucaccggugcacucgggacggcucaggccagcaucgguuuuggc
ggggggauaaagguccggggaacguagcuccuccgggaguguuauagccc
cgggcguaaugcccucgccgggaccgagguucgcgcaucugcaaggaugc
uggcguaauggucaucaacgacccgucuugaaacacggaccaaggaguca
agguuuugcgcgaguguuuggguguaaaacccgcacgcguaaugaaagug
aacguaggugagagcuucggcgcaucaucgaccgauccugauguauucgg
auggauuugaguaagagcguuaagccuuggacccgaaagauggugaacua
ugcuuggauagggugaagccagaggaaacucugguggaggcucgcagcgg
uucugacgugcaaaucgaucgucaaaucugagcaugggggcgaaagacua
aucgaaccaucuaguagcugguuaccgccgaaguuucccucaggauagca
guguuguucuucaguuuuaugagguaaagcgaaugauuagggaccauucu
caaacuuuaaauauguaagaagcccuuguuacuuaauugaacgugggcau
ucgaauguaccaacacuagugggccauuuuugguaagcagaacuggcgau
gcgggaugaaccgaacgcgggguuaaggugccggaguggacgcucaucag
acaccacaaaaggcguuaguacaucuugacagcaggacgguggccaugga
agucggaauccgcuaaggacuguguaacaacucaccugccgaauguacua
gcccugaaaauggauggcgcucaagcgucccacccauaccccgcccucag
gguagaaacgaugcccugaggaguaggcggccguggaggucagugacgaa
gccuagggcgugagcccgggucgaacggccucuagugcagaucuuggugg
uaguagcaaauacuucaaugagaacuugaaggaccgaaguggggaaaggu
uccaugugaacagcgguuggacauggguuagucgauccuaagccauaggg
aaguuccguuucaaaggggcagugccccguguggcgaaagggaagccggu
uaacauuccggcaccuggauguggguuuugcgcggcaacgcaacugaacg
cggagacgacggcgggggccccgggcagaguucucuuuucuucuuaacgg
ucuaucacccugaaaacaguuugucuggagauaggguuuaauggccggaa
gagcccgacacuucugucggguccggugcgcucucgacgucccuugaaaa
uccgcgggagggaauaauucucacgccaggucguacucauaaccgcagca
ggucuccaaggugaacagccucugguugauagaacaauguagauaaggga
agucggcaaaauagauccguaacuucgggaaaaggauuggcucuaagggu
uggacaaccaacuuagaacugguacggacagggggaaucugacugucuaa
uuaaaacauagcauugcgauggccagaaagugguguugacgcaaugugau
uucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcgg
guaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgu
caucuaauuagugacgcgcaugaauggauuaacgagauucccacuguccc
uaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaauc
agcggggaaagaagacccuguugagcuugacucuaguuugacauugugaa
aauuuuuuuacuuauucaauuaagcggggcuggauuuucguccaacuucu
gguuuuaagguccuucgcgggccgacccggguugaagacauugucaggug
gggaguuuggcuggggcggcacaucuguuaaaccauaacgcagguguccu
aaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaa
guccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggc
cuaucgauccuuuagucccucgaaauuugaggcuagaggugccagaaaag
uuaccacagggauaacuggcuuguggcggccaagcguucauagcgacguc
gcuuuuugauccuucgaugucggcucuuccuaucauaccgaagcagaauu
cgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuu
agaccgucgugagacagguuaguuuuacccuacugaugaccucaucgcaa
ugguaauugagcuuaguacgagaggaaccgcucauucagauaauugguuu
uugcgguuguccgaccgggcagugccgcgacgcuaccaucugcuggauaa
uggcugaacgccucuaagucagaauccaugccagaacgcgaugauaccuc
cagcacguuguagacguauaagaauaggcuccggccucguaucuuagcag
gcgauuccuccguuggccuugaaguggccagcgguaauucgcguauugua
auuuuaacacgcgcuggaucaaauccuuugcagacgacuuagaugugcga
aaggguccuguaagcaguagaguagccuuguuguuacgaucugcugaggg
uaagcccuccuucgccuagauuu
........................<<<<<<.....<......>......>
>>>>.>.........<<....>>..<<<<<......<<.....>>.....
>>>>>..<<<..<<.......<<.<<<....>>>.>>.......>>....
<<<<.<<<<<.<<<...<<<<<<..<<....<<<<......>>>>.((..
....<<<.....))>>>....>>..>>.>>>>...>>>.....>>>>>.>
>>>........<<<<<<<........>>>>>>>.....<<<<<..(((((
(>>>>>..>>>..................................<<...
.>>...............<<<<....>>>>....................
..............<<<<.<<<<<<.....<<.<<<<<<<....<....<
<....>>....>........>>>.>>>>.>>.<<<<<<<.<<<<<<<<<<
<<<<<.....<.<<<<<<<<......<<<<<....>>>>>.......>>>
>>>>>....>.>>>>>>>>>>>>>>>........<<<..>>>.....>>>
>>>>.....>>>>>>.>>>>..<<<<........>>>><<<<<<....<<
<<<<<<.<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.
......<<<<<..<<....>>...>>>>>.<<<<<<<<...<<....>>.
..>>>.>>>.>>....>>>>.>>>>>>>>..<<.<..<<<<<<<.....<
<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<.
.<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>.
.....>>>>>>...>..>.>>...<<<<<....<.<<<....>>>.><<<
<<<<<<.....<<.<<<<<<<.....<<<....<<<..<.<<.>>.>..>
>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>..
...>>>>...>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>...
.<<<......>>>...<<<<<<<...<<<(((.....<<<<<<......<
..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.....
....>>...>>>.........<........>...>>>>>...>>>>>>>>
>>>>>..........))).>....>>>>>>.>>>...>>>>>>><<<<<<
<<<.........>>>>>>>>>....>>>>>.<.<<<<<<<<.<<......
<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<
.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<..
.<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<...<<<
....>>>........<<<<<<.>>>>>>....>>>....>>...<<<<<.
.......>>>>>))<<<<.<<<<.<<<....<<<....>>>......(<<
<<<<...<<<<.<<<<<<<<<<<<<.<<<<.......>>>>.><...<<<
<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>...
.><<<<<<<<....>>>>>>>>>>>>.>.>>>>>>>.>>>>.........
>>>>>>.........>>>...>>>>>>>>>>>>..>>.....<<......
>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<..
.......<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<
<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<....
.....>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...
<<..<<<..<<<<<<....<<<....<<<<<....>>>>.>...>>>.>>
>>..>>>>><<<<<<.......>>>>>>........<...........<<
<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.
>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<
<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<
<....>>>>>>...<<<<<.....<<<<..<<<<......>>>>......
....)...<<<<<.....>>>>>..>>>>..>>>>>.....>>>>>>>>.
.>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<.
..<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....
>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)
))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>
>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>
>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>
>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>...
.<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<..
<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<..
..<<<<<<<<<<....>>>>>..>>>>>...>>>>..>>>>>.<<<<...
<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>....<<
<<<<.<<<.<<......<<.......<<<....>>>....>>........
<<<<.....<<<<<<<<<.......>>>>>>>>>....>>>>........
......>>>>>.>>>>>>..<<.<.<<.............>>....<.<<
.<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>
....>>>>..>>..>...>.>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7r81 Structure of the translating Neurospora ribosome arrested by cycloheximide
Resolution2.7 Å
Binding residue
(original residue number in PDB)
R14 G15 R16 H35 Y37 R47 K51 T53 R54 R55 M56 S57 R60 K68 K72 V73 I74 N75 N77 H78 R106 K115 E118 R134 F135
Binding residue
(residue number reindexed from 1)
R14 G15 R16 H35 Y37 R47 K51 T53 R54 R55 M56 S57 R60 K68 K72 V73 I74 N75 N77 H78 R106 K115 E118 R134 F135
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component
External links
PDB RCSB:7r81, PDBe:7r81, PDBj:7r81
PDBsum7r81
PubMed34815343
UniProtQ1K580

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