Structure of PDB 7oyc Chain b1 Binding Site BS01

Receptor Information

>7oyc Chain b1 (length=63) Species: 8355 (Xenopus laevis)

AKSKNHTTHNQSRKWHRNGIKKPKSQRYESLKGVDPKFMRNMRFAKKHNK
KGFKKMLANNAKN

Ligand information

>7oyc Chain 51 (length=3245)

ucagaccucagaucagacgcggcgacccgcugaauuuaagcauauuacua
agcggaggaaaagaaacuaaccaggauucccccaguaacggcgagugaag
agggaagagcccagcgccgaauccccgcccgcgggcgcgggacguguggc
guacgggagaccggacccccccggcgcgcgggggcccaaguccuucugau
cgaggcccagcccgcggacgguguuaggccgguggcggcccccggcgcgg
cgggacccggucuccucggagucggguuguuugggaaugcagcccaaagc
gggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagcgg
acaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaag
agggcgugaaaccguuaagagguaaacgggugggguccgugcgguccgcc
cggaggauucaacccggcggguccgccggccggaccgggccacucggcgg
gacgcggcccgggcggccccggcgcccgcagggcgcauuuccuccgcggc
ggugcgccgcgaccggcuccgggccggcugggaaggcccagggguucagg
ggaguuacagcccccccccaggcagcaucgccgucgcccggggccgaggg
uccgcggccuccuccccaagggggaaggggccccccgcucccggcgcggc
gcggacugcccccagugcgcgccgcgccgccgaggcgggagggcccgcgg
gagccgccagggguccgcggcgaugucggugucccacccgacccgucuug
aaacacggaccaaggagucuaacgcgcgcgcgagucggagggacgcgaaa
cccuguggcgcaaugaaggugagggccggggcgccccggcugagguggga
ucccgccgcgccggcgggcgcaccaccggcccgucucgcccgccccgucg
gggagguggagcgugagcgcgcgcgauaggacccgaaagauggugaacua
ugccugggcagggcgaagccagaggaaacucugguggagguccguagcgg
uccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacua
aucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcu
ggcgcucguccgucgcaguuuuauccgguaaagcgaaugauuagagguac
cuauucucaaacuuuaaauggguaagaagcccggcucgcuggcuuggagc
cgggcguggaaugcgagcacgccuagugggccacuuuugguaagcagaac
uggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacg
cucaucagaccccagaaaagguguugguugauauagacagcgccgaauca
acuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccg
ucgccggcgcugggcuaggccgcgacgaguaggagggccgccgcgguggg
cgcggaagccccgggcgagggcccggguggagccgccgcgggugcagauc
uuggugguaguagcaaauauucaaacgagaacuuugaaggccgaagugga
gaaggguuccaugugaacagcaguugaacaugggucagucgguccuaaga
gaugggcgagcgccguucggaagggcggccgaucgaaagggagucggguu
cagauccccgaacccggagcggagacgggcguccagugcggcgacgcgac
cgaucccggagaagccggcgggagccccggggagaguucucuuuucuuug
ugaagggcagggccgcccuggaauggguucgccccgagagaggggcccgc
gccuuggaaagcgucgcgggcggcguccggugagcucucgcuggcccuug
aaaauccgggggagaggguguaaaucucgcgccgggccguacccauaucc
gcagcaggucuccaaggugaacagccucuggcauguuagaacaauguagg
uaagggaagucggcaagucagauccguaacuucgggauaaggauuggcuc
uaagggcuggcagcugacuuagaacuggugcggaccaggggaauccgacu
guuuaauuaaaacaaagcaucgcgaaggcccgaggcggguguugacgcga
ugugauuucugcccagugcucugagucaaagugaagaaauucaaugaagc
gcggguaaacggcaagguagccaaaugccucgucaucuaauuagugacgc
gcaugaauggaugaacgagauucccacugucccuaccuacuaucuagcga
aaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacc
cuguugagcuugacucuagucugcaacugugaaguuucacuuacccggug
aggcggggggcuucuggacccaagcgcccggcgggcgcgacccgcuccga
ggacaguggcagguggggaguuugacuggggcgguacaccugucaaaccg
uaacgcagguguccuaaggcgagcucagggaggacagaaaccucccgugg
agcagaagggcaaaagcucgcuugaucuugauuuucaguaugaauacaga
ccgugaaagcggggccucacgauccuucugacuuuuuggguuuuaagcag
gaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagc
guucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuauca
uugugaagcagaauucaccaagcguuggauuguucacccacuaauaggga
acgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacug
augauguguugucgcaauaguaauccugcucaguacgagaggaaccgcag
guucagacauuugguguaugugcuuggcugaggagccaauggggcgaagc
uaccaucugugggauuaugacugaacgccucuaagucagaauccccccua
aacgugacgauaagcgccgcggagccucggucggccucggauagccggcg
cgccggcgggcagagccgcucgccucgggaccggagcgcggacgaaaggg
ggccgccucucucccggagcgcaccgcacguucguggggaaccuggugcu
aaaucauucguagacgaccugauucugggucaggguuucgugcguagcag
agcagcgcugcgaucuauugaaagucaucccuugagccauuuugu

.........................<<<<<<.....<......>......
>>>>>.>.........<<....>>..<<<<<......<<.....>>....
.>>>>>..<<<..<<<<<...<<<<<<<<<..>>>>>.>>>>.....>>>
>>..<<<<<<<<<......<<<<.<<<<<<<<<<<<.....<<<<.....
.>>>>.....((......<<<.....))>>>.....>>>>>>>>.>>>>.
>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....
<<<<<..((((((>>>>>..>>>...........................
.......<<....>>...............<<<......>>>........
..........................<<<<<<<<..<<<.......<<<<
.<<<<<<.....<<<.<<<<<<...<.<<.......<<.....<<.....
>>.....>>........>>.>..>>>>>>.>>>......>>>>>>..>>>
>.....<...<.<.<.<<<.<<.<.<....<<........<<<<......
............>>>>...........>>.>.>...>>.>>>.>.>....
...<<<<<.<<<<<<....>>>>>>.<<<<<<<<<<<<<..<<<<<<<<<
<<<.<<<<....>>>>.>>>>>>>>>>>>....>>>>>>.>>>>>>.>..
..>>>>>......>....>.......>>>...>>>>>>>>..<<<<....
....>>>><<<<<<....<<<.<<<<<<<<<..<<<..<<<<........
>>>>..>>>...<<....>>...<<<<<<<....>>>>>>>..<<<<<..
.<<<<<<<...>>>>>>>....>>>>>.<<<<<<<<<.<<<<......>>
>>>>>>>>>.>>....>>>>>>>>>.>>>..<<.<..<<<<<<<.....<
<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<.
.<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>.
.....>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.
<<<<<<<.......<<<.<<<<<<<<<...<<<....<<<....<<<..>
>>....>>>..>>.>...>>>>>>>...<<<<<<<<<.........>>>>
>>>>>....>>>>>>>>>..>>>..>>..<<<<.<<<<<.....>>>>>.
>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<
<.....<<..........<<<.<<<<<<<<<<.......<..>...>>>>
>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<
<<<<.<<<..........>>>>>>>>>....>>>>>>...<<<<<<<<.<
<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>
>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<
<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<
....<<<....>>>..................>>....>>...<<<<<..
......>>>>>))<<<<.<<<<....<<<..>>>...<<<....>>>...
<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>.
...<<<<<.<<<<..<<<<.....<<<.....>>>.....>>>>>>>>..
>>>>>.....<<<<<<<..>>>>>>>>>>>...>>>>>>>>>>>>.....
....>>>>>>>..>..........>..>>>.>>>>>>>>..>>.....<<
......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<
<<.<<.........<.....<<<<<...............>>>>><<.<<
<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<
<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>
>>>...<<...<<..<<<<<<.<.<<.....<<<<....>>>>.....>>
.>>>>>..>>>>.......<...........<<<<<.......>>>>>..
...>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>..
..>>....<<<<<........>>>>>....<<<<<..<<<.<<......<
<<<.<<<<<<..<<<<<.<<<<<<.<<.<<<<<..>>>>>...<.<<<..
...<<<<................<<<<<<<.>>>>>>>..>>>>..>>>.
>....>>.>>>>>>..>>>>>...<<<.....>>>..<<<<<<.......
....>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>....
.<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>
<<<<....>>>>>>)))].....<<<<<<<...<<..)))))).>>.>>>
>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<
.......>>...>>>>>>....>.>.>.......<.<<<.<<<<<<..<.
<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>
..>...>>>..>....<<<<<<<....>>>.>>>>....>>..>>>.>>>
>>.....<<<<<<<<..<<<....<<<<<.................>>>>
>..<<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>
>>...>>>>.<<<....<<<<<...........>>>>>....>>>..>>>
...>>>>>>>>.<<<<<<<..<..<<<.....<<<........<<<<<<.
.>>>>>>.......>>>...<<<...<<<<...<<<.<<<<.........
..>>>>>>>..>>>>...>>>...............>>>..>.>>>>>>>
<<<...<.............>....<<<.<<<<<<.<<.....<<<<...
.<<<<..>>>>...>>>>....>>....>>>.>>>.>>>.>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7oyc A molecular network of conserved factors keeps ribosomes dormant in the egg.
• Resolution: 2.4 Å
• Binding residue (original residue number in PDB): A2 K3 S4 K5 N6 H7 T8 T9 H10 Q12 S13 R14 K15 H17 R18 N19 K22 S26 Q27 R28 Y29 S31 K33 G34 D36 K38 F39 R41 N42 M43 R44 F45 A46 K47 K48 H49 N50 K51 G53 K56 M57 N60 N61
• Binding residue (residue number reindexed from 1): A1 K2 S3 K4 N5 H6 T7 T8 H9 Q11 S12 R13 K14 H16 R17 N18 K21 S25 Q26 R27 Y28 S30 K32 G33 D35 K37 F38 R40 N41 M42 R43 F44 A45 K46 K47 H48 N49 K50 G52 K55 M56 N59 N60

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7oyc, PDBe:7oyc, PDBj:7oyc
• PDBsum: 7oyc
• PubMed: 36653451
• UniProt: Q66KW1