Structure of PDB 8rbz Chain b Binding Site BS01

Receptor Information
>8rbz Chain b (length=1051) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LQFVSPFAFEAMQKVDVVCLASLSDPELRLLLPCLVRMALCAPADQSQSW
AQDKKLILRLLSGVEAVNSIVALLSVDFHALEQDASKEQQLRHGLTLEFE
HSDSPRRLRLVLSELLAIMNKVSESNGEFFFKSSELFESPVYLEEAADVL
CILQAELPSLLPIVDVAEALLHVRNGAWFLCLLVANVPDSFNEVCRGLIK
NGERQDEESLGGRRRTDALRFLCKMNPSQALKVRGMVVEECHLPGLGVAL
TLDHTKDGVSDLVCFVSGLLLGTNAKVRTWFGTFIRNGQQRKRETSSSVL
WQMRRQLLLELMGILPGLKEEHVVKASALLRLYCALMGIAGLKPTEEEAE
QLLQLMTSRPPATPAGVRFVSLSFCMLLAFSTLVSTPEQEQLMVVWLSWM
IKEEAYFESFGEMLLLVAMYFHSNQLSAIIDLVCSTLGMKIVIKPSSLSR
MKTIFTQEIFTEQVVTAHAVRVPVTSNLSANITGFLPIHCIYQLLRSRSF
TKHKVSIKDWIYRQLCETSTPLHPQLLPLIDVYINSILTPASKSNPEATN
QPVTEQEIQRFSITAQLLVLYYILSYEEALLANTKTLAAMQRKPKSYSSS
LMDQIPIKFLIRQAQGLQQELGGLHSALLRLLATNYPHLCIVDDWICEEE
ITGTDALLRRMLLTNNAKNHSPKQLQEAFSAVPVNNTQVMQIIEHLTLLS
ASELIPYAEVLTSNMSQLLNSGVPRRILQTVNKLWMVLNTVMPRRLWVMT
VNALQPSIKFVRQQKYTQNDLMIDPLIVLRCDQRVHRCPPLMDITLHMLN
GYLLASKAYLSAHLKETEQTREELKNALLAAQDSAAVQILLEICLPTEEE
KADNLLCNLREVQCLICCLLHQMYIADPNIAKLVHFQGYPCELLPLTVAG
IPSMHICLDFIPELIAQPELEKQIFAIQLLSHLCIQYALPKSLSVARLAV
NVMGTLLTVLTQAKRYAFFMPTLPSLVSFCRAFPPLYEDIMSLLIQIGQV
CASDVATQTRDIDPIITRLQQIKEKGSMDPDVQLCHCIERTVIEIINMSV
S
Ligand information
Receptor-Ligand Complex Structure
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PDB8rbz Structural basis of Integrator-dependent RNA polymerase II termination
Resolution3.7 Å
Binding residue
(original residue number in PDB)		I1006 S1034 H1036 I1037 L1070
Binding residue
(residue number reindexed from 1)		I875 S903 H905 I906 L939
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0016180 snRNA processing
GO:0034243 regulation of transcription elongation by RNA polymerase II
GO:0034472 snRNA 3'-end processing
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0031965 nuclear membrane
GO:0032039 integrator complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8rbz, PDBe:8rbz, PDBj:8rbz
PDBsum8rbz
PubMed38570683
UniProtQ9H0H0|INT2_HUMAN Integrator complex subunit 2 (Gene Name=INTS2)

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