Structure of PDB 7yf0 Chain b Binding Site BS01

Receptor Information
>7yf0 Chain b (length=1074) Species: 538123 (Mammalian orthoreovirus 3) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QCHVCSAVLFSPLDLDAHVASHGLHGHITEFISSWQNHPIVQVSADVENR
KTAQLLHADTPRLVTWDAGLCTSFKIVPIVPAQVPQDVLAYTFFTSSYAI
QSPFPEAAVSRIVVHTRWASNVDFDRDSSVIMAPPTENNIHLFKQLLNTE
TLSVRGANPLMFRANVLHMLLEFVLDNLYLNRHTGFSQDHTPFTEGANLR
SLPGPDAEKWYSIMYPTRMGTPNVSKICNFVASCVRNRVGRFDRAQMMNG
AMSEWVDVFETSDALTVSIRGRWMARLARMNINPTEIEWALTECAQGYVT
VTSPYAPSVNRLMPYRISNAERQISQIIRVMNIGNNATVIQPVLQDISVL
LQRISPLQIDPTIISNTMSTSPASSILGKLRPSNSDFSSFRVALAGWLYN
GVVTTVIDDSSYPKDGGSVTSLENLWDFFILALALPLTTDPCAPVKAFMT
LANMMVGFETIPMDNQIYTQSRRASAFSTPHTWPRCFMNIQLISPIDAPI
LRQWAEIIHRYWPNPSQIRYGTPNVFGSANLFTPPEVLLLPIDHQPANVT
TPTLDFTNELTNWRARVCELMKNLVDNQRYQPGWTQSLVSSMRGTLGKLK
LIKSMTPMYLQQLAPVELAVIAPMLPFPPFQVPYVRLDRDRVPTMVGVTR
QSRDTITQPALSLSTTNTTVGVPLALDARAITVALLSGKYPPDLVTNVWY
ADAIYPMYADTEVFSNLQRDVITCEAVQTLVTLVAQISETQYPVDRYLDW
IPSLRASAATAATFAEWVNTSMKTAFDLSDMLLEPLLSGDPRMTQLAIQY
QQYNGRTFNVIPEMPGSVIADCVQLTAEVFNHEYNLFGIARGDIIIGRVQ
STHLWSPLAPPPDLVFDRDTPGVHIFGRDCRISFGMNGAAPMIRDETGMM
VPFEGNWIFPLALWQMNTRYFNQQFDAWIKTGELRIRIEMGAYPYMLHYY
DPRQYANAWNLTSAWLEEITPTSIPSVPFMVPISSDHDISSAPAVQYIIS
TEYNDRSLFCTNSSSPQTIAGPDKHIPVERYNILTNPDAPPTQIQLPEVV
DLYNVVTRYAYETPPITAVVMGVP
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7yf0 Chain b Residue 2001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7yf0 In situ structures of polymerase complex of mammalian reovirus illuminate RdRp activation and transcription regulation.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		C183 H199 H203
Binding residue
(residue number reindexed from 1)		C2 H18 H22
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006370 7-methylguanosine mRNA capping
Cellular Component
GO:0019028 viral capsid
GO:0039625 viral inner capsid

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7yf0, PDBe:7yf0, PDBj:7yf0
PDBsum7yf0
PubMed36469786
UniProtC9E874

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