Structure of PDB 7pnv Chain b Binding Site BS01

Receptor Information
>7pnv Chain b (length=323) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LHIPVMVDQVVHCLAPQKGQVFLDMTFGSGGHTRAILQKEPDVMVYALDR
DPVAYAIAEQLSRLYPTQIQALLGQFSQAEALLMKAGVQPGTIDGILMDL
GCSSMQLDAPERGFSLRKDGPLDMRMDGDRYPDTPTASDVVNALDQQALA
SILRAYGEEKHAKKIASAIIQARSTYPISRTQQLASIVAGAFPPSAVYAR
KDLLQRSTHIATKTFQALRIFVNNELNELYAGLRTAEKFLKTGGRLVALS
FHSLEDRIVKRFLLGISMTERFNLSIRQKVKQTSVRAPLKWELIHKKVLT
PEDQDVQDNPRGRSAKLRAAIKL
Ligand information
>7pnv Chain A (length=951) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aaagguuugguccuggccuuauaauuaauuagagguaaaauuacacaugc
aaaccuccauagaccgguguaaaaucccuuaaacauuuacuuaaaauuua
aggagaggguaucaagcacauuaaaauagcuuaagacaccuugccuagcc
acacccccacgggacucagcagugauaaauauuaagcaauaaacgaaagu
uugacuaaguuauaccucuuaggguugguaaauuucgugccagccaccgc
ggucauacgauuaacccaaacuaauuaucuucggcguaaaacgugucaac
uauaaauaaauaaauagaauuaaaauccaacuuauaugugaaaauucauu
guuaggaccuaaacucaauaacgaaaguaauucuagucauuuauaauaca
cgacagcuaagacccaaacugggauuagauaccccacuaugcuuagccau
aaaccuaaauaauuaauuaacaaaacuauuugccagagaacuacuagcca
uagcuuaaaacucaaaggacuuggcgguacuuuauauccaucuagaggag
ccuguucuauaaucgauaaaccccgcucuaccucaccaucucuugcuaau
ucagccuauauaccgccaucuucagcaaacccuaaaaagguauuaaagua
agcaaaagaaucaaacauaaaaacguuaggucaagguguagccaaugaaa
ugggaagaaaugggcuacauuuucuuauaaaagaacauuacuauacccuu
uaugaaacuaaaggacuaaggaggauuuaguaguaaauuaagaauagaga
gcuuaauugaauugagcaaugaaguacgcacacaccgcccgucacccucc
ucaaauuaaauuaaacuuaacauaauuaauuucuagacauccguuuauga
gaggagauaagucguaacaagguaagcauacuggaaagugugcuuggaau
a
..((((..<<<<<<.)))).<<<<<<<.<..<<<<<<<<..<.<<<.<<<
..<......>......<<......<<<<<<<<<..<<<<..>>>>.>>>>
>>>.>>.<<<....<<...<<....>>..>>......>>>..<<...>>.
>>.<<<....>>>.....>>>>>>>.........<<....<<<<....>>
>>..>>...>>.>>>>>>...<<<<<<<<.....(((.....((.>>>))
.......)))..>>>>>..>.>>>>>>>....<<<((.....<<<<....
<<............<<<<<<....<<<<<<<....<<......>>.....
>>>.>>>..>..........<<....>>.>>>>>>......>>....>>>
>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>...
.......<<<<.<<.....))..>>.>>>>.>>>.<<<.......<<<..
..>>>.....>>>..>>>>>><<<<<.<<<<<<........<<<<<..<<
<<<<<<<<.....<<........>>..........<<<<.<<........
...<<.<<<..<<<<<<.......<<..<<<<<....>>>.......>>.
.>>......<<.....>>..........>>>...>>>>>>>>....>>.>
>>>..>>.>>>>>>>>.....<<<<<....>>>>>.....<<..<.<<<<
<<......>>>>>>..>.>>.....>>>>>.....<<<<<<<........
.>>>>>>>............>>>>>>>>>.>>....<..<<.<...<<<<
<<..<.<<<<<....<<....<<.....>>....>>......>>>>>>..
>>>>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>.....
.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7pnv Mechanism of mitoribosomal small subunit biogenesis and preinitiation.
Resolution3.06 Å
Binding residue
(original residue number in PDB)		K230 H231 F262 P263 R270 S323 S345 V350 K351 Q352 K380
Binding residue
(residue number reindexed from 1)		K160 H161 F192 P193 R200 S253 S275 V280 K281 Q282 K297
Enzymatic activity
Enzyme Commision number 2.1.1.-
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0071424 rRNA (cytosine-N4-)-methyltransferase activity
Biological Process
GO:0032259 methylation
GO:0070475 rRNA base methylation
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7pnv, PDBe:7pnv, PDBj:7pnv
PDBsum7pnv
PubMed35676484
UniProtQ9DCL4|MET15_MOUSE 12S rRNA N4-methylcytidine methyltransferase (Gene Name=Mettl15)

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