Structure of PDB 7oi8 Chain b Binding Site BS01

Receptor Information

>7oi8 Chain b (length=148) Species: 9606 (Homo sapiens)

TARGTPSRFLASVLHNGLGRYVQQLQRLSFSVSRDGASSRGAREFVEREV
IDFARRNPGVVIYVNSRPCCVPRVVAEYLNGAVREESIHCKSVEEISTLV
QKLADQSGLDVIRIRKPFHTDNPSIQGQWHPFTNKPTTFRGLRPREVQ

Ligand information

>7oi8 Chain A (length=1092)

gcuaaaccuagccccaaacccacuccaccuuacuaccaaaccuuagccaa
accauuuacauaaaguauaggcgauagaaauugggcgcaauagauauagu
accgcaagggaaagaugaaaaauaccaagcauaauauagcaaggacuaac
cccuauaccuucugaugaauuaacuagaaauaacuuugcaaggagagcca
aagcuaagacccccgaaaccagacgagcuaccuaagaacagauuuauagg
uagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauag
aaucuuaguucaacuuuaaauuugcccacagaaccaaauccccuuguaaa
uuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaac
cuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagc
caccaauuaagaaagcguucaagcucaacaccucccaaacauauaacuga
acuccucacacccaauuggaccaaucuaucacccuauagaagaacuaaug
uuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucaga
ucacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuau
uacccucacugucaacccaacaggcaugcucauaaggaaagguuaaaaaa
aguaaaaggaaacaucaccucuagcaucaccaguauuagaggccagcugu
cucuuacuuuuaaccagugaaauugaccugcccgugaggcgggcauaaca
cagcaagacgagacccuauggagcuuuaauuuauuaaugcaaacaccugc
auuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgagc
aguacaugcuaagacuucaccagucaaagcgaaccucaauugauccaaua
acuugaccaacggaacaaguuacccuaggguaucuacuuuauuccucccu
guacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucuaaa
ugauaucaucucaacuuaauacccacacccaagaacaggguu

<<<.......<<<<..................................<.
.....>.....<.....<<.....>>....>..>>.>>............
.<<....>>..................>>>...........<<<......
.>>>...<.<....>.>.<<<<<<.........<<<.<<..<<....>>.
..>>.>>>...<<.<...<<<<.<.....<<<<<.<<<....>>>.>>>>
>...<<.......>>......>.>>>>......>.>>..<<<<<<....<
<<<....>>>><<<.<<<<<<<<<<.....<<......>>.....>>>>>
>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>
>>....<<<.<<<...<..............<....<<<.........>>
>....>.......<<<......>>>......................>..
.>>>>>>........>>>>>>...<<<<<......>>>>>.........>
>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<.
...>>>>>......<<<...<<<<.......................>>>
>.......>>>.....<<....>>.>>>>.....>>>>..<<<<...<<<
<<<<<.<<.........<<<<<<.............>>>>>>........
>>.>>>>>>>>>>>>.>>.....>.....<<<<<.....>>>>>......
.<<..<<<.....<<<<<.<<<<<<..<<<<<.<<<<<<<<......>>>
>>>>>>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..
<<.....<<<..<<<<.....>>>>..>>>....>>.........<<<..
..>>>............>>>>..>>>>>>>..>>>.>>..<<<.<<<...
..............>>>.>>><<<<<...<<<....>>>.>>>>>.<<<.
<............>.>>>........<<<<.......>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7oi8 A distinct assembly pathway of the human 39S late pre-mitoribosome.
• Resolution: 3.5 Å
• Binding residue (original residue number in PDB): T2 A3 R4 F10 D36 A38 S39 R68 C70 C71 H90 R114 R116
• Binding residue (residue number reindexed from 1): T1 A2 R3 F9 D35 A37 S38 R67 C69 C70 H89 R113 R115

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0006412 translation
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005761 mitochondrial ribosome
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7oi8, PDBe:7oi8, PDBj:7oi8
• PDBsum: 7oi8
• PubMed: 34315873
• UniProt: Q8N983|RM43_HUMAN Large ribosomal subunit protein mL43 (Gene Name=MRPL43)