Structure of PDB 7ods Chain b Binding Site BS01

Receptor Information

>7ods Chain b (length=149) Species: 9606 (Homo sapiens)

TARGTPSRFLASVLHNGLGRYVQQLQRLSFSVSRDGASSRGAREFVEREV
IDFARRNPGVVIYVNSRPCCVPRVVAEYLNGAVREESIHCKSVEEISTLV
QKLADQSGLDVIRIRKPFHTDNPSIQGQWHPFTNKPTTFRGLRPREVQD

Ligand information

>7ods Chain A (length=1445)

gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagc
caaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcg
caauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcaua
auauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaa
auaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcu
accuaagaacagcuaaaagagcacacccgucuauguagcaaaauaguggg
aagauuuauagguagaggcgacaaaccuaccgagccuggugauagcuggu
uguccaagauagaaucuuaguucaacuuuaaauuugcccacagaacccuc
uaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuug
gacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauag
uaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacacaaa
aaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuau
cacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucucc
uccgcauaagccugcgucagauuaaaacacugaacugacaauuaacagcc
caauaucuacaaucaaccaacaagucauuauuacccucacugucaaccca
acacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggc
aaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccagu
auuagaggcaccgccugcuggcuccacgaggguucagcugucucuuacuu
uuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaa
gacgagaagacccuauggagcuuuaauuuauuaaugcaaacagaaaccug
cauuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgag
caguacaugcuaagacuucaccagucaaagcgaacacucaauugauccaa
uaacuugaccaacggaacaaguuacccuagggaagcgcaauccuauucua
gaguccauaucaacaauaggguuuacgaccucguuggaucaggacauccc
gauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccua
cgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuu
caaauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaa
agcgccuucccccguaaaugauaucaucucaacuuaguauacccacccca
cccaagaacaggguuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuu

<<<.......<<<<....................................
.<......>...............<<.....>>.............>>.>
>.............<<....>>......................>>>...
........<<<.......>>>...<.<........>.>.<<<<<<.....
....<<<.<<..<<....>>...>>.>>>...<<.<...<<<<.<.....
<<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>
....>>>.>>>>>...<<.......>>......>.>>>>......>.>>.
.<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<......
....>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>
>>>...<<<......>>>....<<<.<<<...<..............<..
..<<<.........>>>....>.......<<<......>>>.........
..................>...>>>>>>........>>>>>>...<<<<<
......>>>>>.........>>>>>><......<<..<<<....>>><<<
<..<<<<........<<<<<..............>>>>>......<<<..
.<<<<.......................>>>>.......>>>.....<<.
.....>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<.........
.......<<<<<<..<<<.........>>>...<<<<<<...........
..>>>>>>....<<<....>>>....>>.>>>>........>>.>>>>>>
>>>>>>.>>.....>.....<<<<<........>>>>>.......<<..<
<<.<<<....<<<<<.<<<<<<..<<<<<.<<<<<<<<..........>>
>>>>>>>>>>>..<<<<((((.>>>><<<<<<...........>>>>>>.
.<<.....<<<..<<<<.....>>>>..>>>.....>>.........<<<
....>>>............>>>>..>>>>>>>......<<<<<<<<<...
<<.......>>...>>>>>>>>>.....)))).<<<<<..<<<<<..<<.
<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>.
.....>>>>>.....<<<<<<<....>>>.>>>>...>>>..>>>.>>..
.<.<<<.<<<.................>>>.>>><<<<<...<<<....>
>>.>>>>>......<<<................>>>...>.........<
<<<.......>>>>...............................

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7ods Stepwise maturation of the peptidyl transferase region of human mitoribosomes.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): X2 A3 R4 D36 A38 P69 C71 V72 R74 H90 R114 R116 K117 P118 F119
• Binding residue (residue number reindexed from 1): X1 A2 R3 D35 A37 P68 C70 V71 R73 H89 R113 R115 K116 P117 F118

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0006412 translation
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005761 mitochondrial ribosome
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7ods, PDBe:7ods, PDBj:7ods
• PDBsum: 7ods
• PubMed: 34135320
• UniProt: Q8N983|RM43_HUMAN Large ribosomal subunit protein mL43 (Gene Name=MRPL43)