Structure of PDB 6ywx Chain b Binding Site BS01

Receptor Information

>6ywx Chain b (length=161) Species: 367110 (Neurospora crassa OR74A)

ATVKQHVQLALSLPPRLRTFLARYPPASILPAGADPETHKTPYQEESPNP
FMPTKHPITGKWHNPKYSLRRQAELVKLAQEHGVEELLPFTRKLNEEKLR
KRVELGLRVKGTGVGEKVKGHKHERTLVAKMEKRREAMLAMPDLIREWKK
VGKRNWTKFPK

Ligand information

>6ywx Chain A (length=2838)

guaauggauauaaagcuuauguuuauauauauauauaaguauauaaagag
acuacuaccaauagcuacacuauguauuaaggagaguauaacuuaauuua
uguuuaugauagagguuaucaacauaugaacucuuagagaaauuacuuaa
uaaacgaagugaauugaaauaucuuauuaacuucaggaaaagaaaucaaa
cgagauucuaugauuagugugaacgaaaauagagcagccuauuaaaauaa
guaaaauggcuuuaaagcuguuugaauauuguggggaaccuuccucaaag
gcuaaauauaauacaugaguuacagagaaaaguaccgugagggaaagcuu
ugaaauaguaguuuuauaagcagcucaagcaauaagaaagcgagagcgua
ccuuuugcauaaugggucaccaaguuaauuuuagaugcgagcgaauuaga
ugugcauaguuaaaccgaucauuaaaauaaugaauagugucuaaaguuag
acccgaagccuggugaucuuacuauagucaggacuauaaagguccgaacg
gguuaucguugcaaagauauccgaagaacuaugguaagcgagugaaagac
aacacugacuaggauagcugguuuucugcgaaaccuauaauaguaggcaa
uuuaaguaacaucuuaguagguacagaacuuaaucucagacaagauguag
auuuucauaccuagguaugaaaugcauuuuuuuuuguauacaucggggga
ucgugaagauuuuaucggugaguauguagacucggaaugacaaagaugaa
ucuugaauaaucagacauagaaugauaagguuguaugucaaaagggaaac
agcccagaacaagaguuaagguuccaaaauuauuauuaagugaaauaaag
aaaguuuuuauauaagucgacaagaagaugggcuuggaagcagccauaau
uuaaagaucucguaacagagcacuuguuaaaucuuaaaagcaucgaaaau
uuaacggaucuaaauaauauaccgaaaccuuguccauauguaacauuagu
aauaauauuaauguuauuugaugggguagcagaacguugagugaaucuua
gauuuuuuuuuuauaacuaaauauagaugauaacucaagugagaauggug
acaugaguaacaaaaaagaguuuaagguaccuaaaagguaucuuagaguc
ucgccuaaagcuuauggcuacgucaaguaacggccucuaaguuuauaauc
ugaagauuaugacgaugagaaaacuuugguaccaacauuuaaaagugaaa
auugugcaggaaggauaaaccguaccuagaaucugaaacaaguaagcuag
uagagaauacgaaggcgugaaugagauaacaaucauaaaggaacucggca
aacuaacuaccguaacuuagggauaaggagagcucauuagucucgaacga
guaaaaaggaagaagcauggaauauuguuguacgacuguuuaauuaaaac
aaagcacuuugcaaaaagacgauaagucuaaguauugagugugauuucug
cccgaugccggcugguuaacgaauuuucuaaauugaaaaaaaauuugguu
ucagaggaacccccgguuaauggcggccuuagcgugaggguccuaaggua
gcgaaaugccuuggccguuaaaugcggucuugcaugaaugauguaacgau
acaacagcugucucuaugauugacucagugaaauuggaauaacugugcag
auacaguuuaccucuaguuagacgagaagacccuaugcagcuuuacuguu
acuaauuauugaauacgauucugaaaauuuccaguguaaaagguaaucga
uaagauauaauugaaacaccuuuauuuuucuaucguauuauuaaaccuua
aauuaaggaacaauuguuagaagacaguuuaugcggggcacaggccccau
aaagaguaaaugggugugucuaaaauguuugcaauuuuuuauaguauaua
ucaaaucaucuuuaugcuauucauagaccuuggguacaguauaaaaauua
uauauguauuaauuuacauauauuuuuucuaagaaauuagguaagauuuu
guuuauagagaaauuagauguaaaaaaaaaaucuuaugagggcggauccg
cuucuaauauuuuuuuguaguuauuauuauaauaauaaucauguuuauua
cuuaaaaagcuuaauggcuuaaucuugccuuacuguuugauuaacaacaa
aucuuacagucgcguaagcggggcauaggaucacaagauacaaaaaggaa
agaucuuggauuuuuggaaaagcuacgcuagggauaacaggcuaauuugc
gcaagaguguacaaaaugagugcgcgguuuggcaccuccggcuugacuaa
uccucauggaugcagaaacuauguaggguacgacuguucgucgauuaaaa
aguuacaugagcuggguuaaauacgucgugagacaguaugguuucuaucu
ucuagagggaauuagaauauaauaaggauuaaccuuuguacgaaaggaac
augggguacuauuguuaacaguuuuauuaaccucugguuuaccuguuguu
uaugugccuuagggauguuaccgucacuugaguaaauacaauagcauaag
cauggcaggaaagcuaaguuagucaaaaauaagugcugaaagcauauagg
cacgaaauuuaccuuaagauauuucuuaaauauacguaagaaaauauuac
guuaauaggcuuaguuuguaauaaucuagagauuuuaaggaacuaaguac
uaauuuuauaaaaaacugaaugauuaauauaucuuaca

<<<<..<<<<<<.......<<<<<<<<<..>>>>...<<<.......<<<
<<<<<<<......<<.....<<<<<<<<..<<<<<<.....>>.....<<
<<<<................>>>>>>....>>>>..<<....>>......
....<<<<<<.....<<....>>......>>>>>.>.........<<...
.>>..<<<<<<.....<<....>>....>>>>>>..<<............
...<<<<<<<<....>>>>>>>>........<<<<<..[[[[>>>>>...
>>.......>>>>>>>>.................<<....>>....>>..
.....>>>>>>>>>>.......<<<<..<<.........>>..>>>>...
<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<.......
..>>>...<......>..<<<<<.....>>>>>...>>>>>>>>>>>>>.
.<<.<..<<<<<<<.....<<<<<<<<<..<<<<<....>>.>>>...<<
<..<<<<........>>>>.>>>....>>>>>>>>>.....<<.....>>
.......>>>>>>.>..>.>>..<<<<<<....<<<<<....>>>>>..<
<<<<<<...<<<<<<.<<.....<<<...<..<<<<<<.<<<<<<<<..<
..<<<<<<<<<..>>>>>>>>>>.>>>>.....>>>>.....<<<<.<<<
<<.....>>>>>..>>>>>>>>.>>..>..>>.>.....>>.>>>>>>..
.>>>>>>>.....<<<<<<.<<<......>>>.>>>>>>....<<<....
..>>>...<<<<<.<<...<<<(((.....<<<<<<.....<<......<
<..<<<<<<<........<<<<<<.<....<<<<.......>>>>....>
........<<<......>>>..>>>>>>......>>>>>>>.>>......
.....)))>>...>>>>>>.>>>...>>>>>>><<<<..<<<<<<<<<<<
<....>>>>>>>>>>>>...>>>>....>>>>>>..<<<<<<..<<<...
.<<..<<..<<...>>..>>..>>....>>>.>>>>>>........>>>>
>><......<<.....<<<.<<<<<<<<<<<.....>>>>>>>>>>>.>>
><<<<<...<<<<<.<<........((...<<<.<<<...<<<.<<<<<<
<..>>>>>>>>>>...>>>....)).........<<<.<<..(((((..>
>.>>>..............>>>..>>......<<......>>>>>>>..<
<<.....>>>..>>>>>....<<<<....<<<<<<<<.<<.........<
......<<.<<....<<..>>.....>>>>..<<<.<<...<<<<..>>>
>....>>.>.>>.............<<<<<<<<<..<<<.........>>
>..<<<<<<.......<<<<.....>>>>.......>>>>>>....<<.<
<<..<<<<<<<..<<....<.......<<<<<<<.......>>>>>>>..
.....>....>>>>>>>..>>>>><<<<<........>>>>>........
<...........<<<<<<.....>>>>>>.....>....>>.....>>.>
>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<.....
...>>>>>..<<<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.
.<<<<<.<<..<<<<<<<<...<<<<<...........<<<<<<.<<<..
...>>>...........>>>>>>..>>>>>.>>>>>>>>......<<<<.
....>>>>....>>.>>>>>...>>>>>...<<.......>>.<<<<<<.
..........>>>>.>>..<<.....<.......<<<..<<<<...>>>>
..>>>.>..........<<<<<<.......>>>>>>.............<
<<<<<<<<......>>>>>>>>>................<<<<<<<....
.<<<<.........>>>>.<<<<..<<<<<<<.<<<.<..<<<<<..>>>
>>.>>>>.>>>.>>>>...<<<<<<<<<..>>>>>>>>>........>>>
>......<<<...(((>>>...>>>>>>>...<<<<..<<<.........
>>>..>>>>.<<<....>>>.>>))).......<<<<<<.<...]]]]..
.>>>>>>>............>>>>..>>>>>>.......<<<<.<...<<
<<<...<.........>...>>>>>....>>>>.>...<<<<.<<<<<..
.<<<<<<<<.........>>>>>..>>>..<<<<.....>>>>.......
>>>>..>...>>>.>.....<<<<<<<....>>>.>>>>....>>..>>>
.>>>>>>>.....<<<<<<...<<<<<...<<<<<...............
>.>>......<<<<<..>>>>>>>.<<<<<<...<<<<...<<<<<<<<<
<<<<<.<<<..>>>...<<<<...)))))..>>>>........>>>>>>>
>>..>>>>>...>>>>.>>>>>>..<<<.<..<<<<<...........>>
>>>...>>>>.>>>>>...>>>.>>>....<<<.<<<<<.......>>>>
>....<<<<<<<<<<<<.....<<<<....>>>>....>>.>>>>>>>.>
>>.....>>>....>>>>>>>>.....>>>>>>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6ywx Analysis of translating mitoribosome reveals functional characteristics of translation in mitochondria of fungi.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): R24 Y44 P54 I59 T60 W63 H64 N65 S69 L70 R71 R72 A74 E75 K78 R93 K94 K102 R103 R109 V110 K111 V119 K120 G121 H122 K123 H124 R126 T127 V129 A130 K131 R135 R155
• Binding residue (residue number reindexed from 1): R23 Y43 P53 I58 T59 W62 H63 N64 S68 L69 R70 R71 A73 E74 K77 R92 K93 K101 R102 R108 V109 K110 V118 K119 G120 H121 K122 H123 R125 T126 V128 A129 K130 R134 R154

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Cellular Component

• GO:0005739 mitochondrion
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6ywx, PDBe:6ywx, PDBj:6ywx
• PDBsum: 6ywx
• PubMed: 33056988
• UniProt: Q7SEK9|RM25_NEUCR Large ribosomal subunit protein mL59 (Gene Name=mrpl25)