Structure of PDB 6t0b Chain b Binding Site BS01

Receptor Information
>6t0b Chain b (length=236) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DVPTPYACYFQDSATPNQEGILELHDNIMFYLLVILGLVSWMLYTIVMTY
SKNPIAYKYIKHGQTIEVIWTIFPAVILLIIAFPSFILLYLCDEVISPAM
TIKAIGYQWYWKYEYSDFINDSGETVEFESYVIPDELLEEGQLRLLDTDT
SMVVPVDTHIRFVVTAADVIHDFAIPSLGIKVDATPGRLNQVSALIQREG
VFYGACSELCGTGHANMPIKIEAVSLPKFLEWLNEQ
Ligand information
Ligand IDCUA
InChIInChI=1S/2Cu
InChIKeyALKZAGKDWUSJED-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Cu][Cu]
FormulaCu2
NameDINUCLEAR COPPER ION
ChEMBL
DrugBank
ZINC
PDB chain6t0b Chain b Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6t0b Rcf2 revealed in cryo-EM structures of hypoxic isoforms of mature mitochondrial III-IV supercomplexes.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		H186 C221 E223 C225 H229 M232
Binding residue
(residue number reindexed from 1)		H171 C206 E208 C210 H214 M217
Annotation score1
Enzymatic activity
Enzyme Commision number 7.1.1.9: cytochrome-c oxidase.
Gene Ontology
Molecular Function
GO:0004129 cytochrome-c oxidase activity
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0006123 mitochondrial electron transport, cytochrome c to oxygen
GO:0009060 aerobic respiration
GO:0022900 electron transport chain
GO:0042773 ATP synthesis coupled electron transport
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0045277 respiratory chain complex IV

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6t0b, PDBe:6t0b, PDBj:6t0b
PDBsum6t0b
PubMed32291341
UniProtP00410|COX2_YEAST Cytochrome c oxidase subunit 2 (Gene Name=COX2)

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