Structure of PDB 6g4w Chain b Binding Site BS01

Receptor Information

>6g4w Chain b (length=82) Species: 9606 (Homo sapiens)

PLAKDLLHPSPEEEKRKHKKKRLVQSPNSYFMDVKCPGCYKITTVFSHAQ
TVVLCVGCSTVLCQPTGGKARLTEGCSFRRKQ

Ligand information

>6g4w Chain 2 (length=1563)

uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugacccccuucgcggggggga
ugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacg
ccggcggcgacgacccauucgaacgucugcccuaucaacuuucgauggua
gucgccgugccuaccauggugaccacgggugacggggaaucaggguucga
uuccggagagggagccugagaaacggcuaccacauccaaggaaggcagca
ggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaa
caauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaa
uccuuuaacgaggauccauuggagggcaagucuggcagcuccaauagcgu
auauuaaaguugcugcaguuaaaaagcucguaguuggaucucucucggcc
gaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggau
accgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuu
ucggaacugaggccaugauuaagagggacggccgggggcauucguauugc
gccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaa
gcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucg
aagacgauaccgucguaguuccgaccauaaacgaugccgaccggcgaugc
ggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaaguc
uuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauug
acggaagggcaccaccaggaguggagccugcggcuuaauuugacucaaca
cgggaaaccucacccggcccggacacggacaggauugacagauugauagc
ucuuucucgauuccguggguggugcauggccguuccugguuaauuccgau
gacucuggcaugcuauucuuagagggacaaguggcguucagccacccgag
auugagcuaacaggucugugugcccuguccggggcugcacgcgcgcuaca
cugacuggcucagcguguccuacgccggcaggcgcggguaacccguugaa
ccccauucgugauggggaucggggauugcaauuauuccccaugaacgagg
aauucccaguaagugcgggucauaagcuugcguugauuaagucccugccc
uuugcaccgcgucgcuacuaccgauuggaugguuuagugaggcccucgga
ucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuu
gacuaucuagaggaaguaaaagucggguuuccguaggugaaccugcggaa
ggaucauuaacgg

...<<<<<.[.(((.>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<......<<....<<<<<.........<<.....<<.<<<...
..>>>.>>......>>.........<<<<...<<<<<<....>>>>>>..
.>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<
<..>>>>>>>.>>.>>>...>>....>>>.<<<....<<<....<<<<<<
<.........>>>>>>>>>>......>>>...<<<<<<<<....>>>>..
.>>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>
>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....
<<<<<<.<<.<<<....>>>.>>..>>>.>>>......<<..<.......
....>..>>.........<<<<<........<<<.>>>.>>>>>..>>>>
>>.>>>.........<.........<.<<...<<<.<<...<<.<<<<>>
>>>>...<<<<<<.<.......<<...<.......>.<<<<.>>>>...>
>......>.>>>..>>>........<.<<.<<<<<<<.............
..>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<<.<<<<
<<<<...<<<......>>>......>>>>>>>>.>>>.......<<....
>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<.
..<<<<....>>>>...>>>>>>>>..........<<<.<<.<<<..<.<
<<<<<.<<<........>>>>>>>>>.>..>>>...<<....>>...>>.
....>>>...>.<<<......<<<<....>>>>....>>>...))).]..
.<<.<<<<<<<..<<..<<<<<.<<<<.<<<<<<.......<........
>...........<<<<<......<<<<<<.......<..<<<........
>>>..>.....>>>>>>...<<<<<<<<<<<<<...<<<......>>>..
..<<<...<...<<......>>..>.....<<<<<.....>>>>>.....
...>>>...>>.>>>>.>>>>>>>....>>>>>...>>.>>>>.>>>.>.
..<<.<<<........<.<<<.<<<<....>>>>.>>>....>.......
..>>>.>>......<.....<<<<<..........>>>>>.....>....
.>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>
>>>>.<<<.<<....<<<<.<<....<<<<<<<<.<<<..<<<<.<<...
<<<<<<<<<<<<<<<<>>>>>>>>>>.>.>>>>>...>>.>>>>..>>>.
>>>>>>>>...>>.>>>>.....>>>>><<<<<<<<<....>>>>>>>>>
.............

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6g4w Visualizing late states of human 40S ribosomal subunit maturation.
• Resolution: 4.5 Å
• Binding residue (original residue number in PDB): R17 H19 P28 G68 G69 K70
• Binding residue (residue number reindexed from 1): R16 H18 P27 G67 G68 K69

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding
• GO:0008270 zinc ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0000028 ribosomal small subunit assembly
• GO:0002181 cytoplasmic translation
• GO:0006364 rRNA processing
• GO:0006412 translation
• GO:0042274 ribosomal small subunit biogenesis

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0014069 postsynaptic density
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:0032040 small-subunit processome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6g4w, PDBe:6g4w, PDBj:6g4w
• PDBsum: 6g4w
• PubMed: 29875412
• UniProt: P42677|RS27_HUMAN Small ribosomal subunit protein eS27 (Gene Name=RPS27)