Structure of PDB 5lf0 Chain b Binding Site BS01

Receptor Information

>5lf0 Chain b (length=203) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TTIMAVQFDGGVVLGADSRTTTGSYIANRVTDKLTPIHDRIFCCRSGSAA
DTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEMCYRYREDLMAGIII
AGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREGMTKE
ECLQFTANALALAMERDGSSGGVIRLAAIAESGVERQVLLGDQIPKFAVA
TLP

Ligand information

>5lf0 Chain h (length=4) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

IITg

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5lf0 The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design.
Resolution	2.41 Å
Binding residue (original residue number in PDB)	T1 T20 T21 G47 A49 S169
Binding residue (residue number reindexed from 1)	T1 T20 T21 G47 A49 S169

Enzymatic activity

Enzyme Commision number

3.4.25.1: proteasome endopeptidase complex.

Gene Ontology

	Molecular Function
GO:0004298	threonine-type endopeptidase activity

	Biological Process
GO:0051603	proteolysis involved in protein catabolic process

	Cellular Component
GO:0005839	proteasome core complex

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Cellular Component

External links

PDB	RCSB:5lf0, PDBe:5lf0, PDBj:5lf0
PDBsum	5lf0
PubMed	27493187
UniProt	P28072\|PSB6_HUMAN Proteasome subunit beta type-6 (Gene Name=PSMB6)

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