Structure of PDB 6zvk Chain a3 Binding Site BS01

Receptor Information

>6zvk Chain a3 (length=313) Species: 9986 (Oryctolagus cuniculus)

TEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETN
YGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRF
VGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWV
SCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVS
PDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAA
TGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAG
YTDNLVRVWQVTI

Ligand information

>6zvk Chain K3 (length=1869)

uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaa
cugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucg
cgggggggaugcgugcauuuaucagaucaaaaccaacccggucagccccu
cuccggccccggccggggggcgggcgccggcggcuuuggugacucuagau
aaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaac
gucugcccuaucaacuuucgaugguagucgccgugccuaccauggugacc
acgggugacggggaaucaggguucgauuccggagagggagccugagaaac
ggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccga
cccggggagguagugacgaaaaauaacaauacaggacucuuucgaggccc
uguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggag
ggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguaua
uuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcg
ggcgguccgccgcgaggcgagccaccgcccguccccgccccuugccucuc
ggcgcccccucgaugcucuuagcugagugucccgcggggcccgaagcguu
uacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauac
cgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuuc
ggaacugaggccaugauuaagagggacggccgggggcauucguauugcgc
cgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagc
auuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaa
gacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcga
ugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaa
gucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaa
uugacggaagggcaccaccaggaguggagccugcggcuuaauuugacuca
acacgggaaaccucacccggcccggacacggacaggauugacagauugau
agcucuuucucgauuccgugggugguggugcauggccguucuuaguuggu
ggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcu
aacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagg
gacaaguggcguucagccacccgagauugagcaauaacaggucugugaug
cccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgug
ugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgug
auggggaucggggauugcaauuauuccccaugaacgaggaauucccagua
agugcgggucauaagcuugcguugauuaagucccugcccuuuguacacac
cgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggc
cccgccggggucggcccacggcccuggcggagcgcugagaagacggucga
acuugacuaucuagaggaaguaaaagucguaacaagguuuccguagguga
accugcggaaggaucauua

...<<<<<.{.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<...<<<..........>>>..>>.>>......<<...
.....<<<.<....<<....<<<<<..................<<.....
<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<...
.>>>>>>...>>>>....<<<<<.....((.{......<<.....<<<.<
<<<<<........>>>>>>..>>>......>>.....<......>..>>>
>>...........<<<<.<<<<......>>>>>>>>.>>>.>>...>>..
>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>....
..>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<.........
.>>>.>>...<<....>>.....>>>>>>.........<<<....<<<<.
..>>>>..>>>..>...>>.>.....<<.<<<.<..<........>..>.
.>>>..>>......<<..<...........>..>>.........<<<<<(
(....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>.
>>>.........<.<[[.....<.<<...<<<.<<.....<<.<<<<<<<
<.<<<<.<<<<....>>>>....>>>>.>>>..>>>>>>>........<<
<<.<<<<<...<<<<<<<......>>>>>>>....>>>>>>>>>.....<
<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>.
.....>.>>>..>>>.......<<....<<<<<<<...........})).
>>>>>>>...>>....>>....<<<<<<......<<<<..<<..<<<<<<
<<...<<<......>>>......>>>>>>>>..>>.......<<....>>
...>>>>.....>>>.>>>...>>>...>>.>....<<<<<<....<...
<<<<.<.....>.>>>>...>.>>>>>>..........<<<.<<.<<<..
<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..]]>>...
>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).
}<<<<<.<<<<<<...<<..<<<<<..<<<.<<<<<<......<<.....
...>>..........<<<<<.<....<<<<<<...........<<.....
...>>.........>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<
<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<
<<..<<<.....<<.<..<<......>>>..>>.....>>>..>>>>..>
.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>
>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<.........
.......<<<.<<<<....>>>>.>>>..............>>>.>>...
.......<.<<<<<..........>>>>>>..........>>>>>.....
<<<<<<<<.......>>>>>>>>......>>....>>>>>>>>>.>>...
.<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<
<<<<<<<<<<<<.......>>>>>>>>>>>.>.>>>>>...>>.>>>>..
>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..
>>>>>>>>>>.........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6zvk The Halastavi arva Virus Intergenic Region IRES Promotes Translation by the Simplest Possible Initiation Mechanism.
• Resolution: 3.49 Å
• Binding residue (original residue number in PDB): G61 S63 H64 R88 R100 K280 E282
• Binding residue (residue number reindexed from 1): G60 S62 H63 R87 R99 K279 E281

Gene Ontology

Molecular Function

• GO:0005080 protein kinase C binding
• GO:0043022 ribosome binding
• GO:0045182 translation regulator activity

Biological Process

• GO:0001934 positive regulation of protein phosphorylation
• GO:0006417 regulation of translation
• GO:0006915 apoptotic process
• GO:0007369 gastrulation
• GO:0048511 rhythmic process
• GO:0072344 rescue of stalled ribosome

Cellular Component

• GO:0001891 phagocytic cup
• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0005886 plasma membrane
• GO:0030425 dendrite
• GO:0042995 cell projection
• GO:0043204 perikaryon
• GO:0048471 perinuclear region of cytoplasm
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6zvk, PDBe:6zvk, PDBj:6zvk
• PDBsum: 6zvk
• PubMed: 33296660
• UniProt: G1SJB4|RACK1_RABIT Small ribosomal subunit protein RACK1 (Gene Name=RACK1)