Structure of PDB 7r81 Chain a2 Binding Site BS01

Receptor Information

>7r81 Chain a2 (length=71) Species: 5141 (Neurospora crassa)

KAQHAVILDKSTSDKLYKDVQSYRLVTVATLVDRLKINGSLARRCLKDLE
EKGQIKQVVGHSKMKIYTRAI

Ligand information

>7r81 Chain A2 (length=1769)

uaccugguugauucugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguuuaagcaauuaaaccgcgaaacugcgaauggcucau
uaaaucaguuauaguuuauuugauaguaccuuacuacauggauaaccgug
guaauucuagagcuaauacaugcuaaaaaccccgacuucagggguguauu
uauuagauuaaaaaccaaugcccuucggggcuaacuggugauucauaaua
acuucucgaaucgcauggccuugcgcuggcgaugguucauucaaauuucu
gcccuaucaacuuucgacggcugggucuuggccagccauggugacaacgg
guaacggaggguuagggcucgaccccggagaaggagccugagaaacggcu
acuacauccaaggaaggcagcaggcgcgcaaauuacccaaucccgacacg
gggagguagugacaauaaauacugauacagggcucuuuugggucuuguaa
uuggaaugaguacaauuuaaaucccuuaacgaggaacaauuggagggcaa
gucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaa
guuguugagguuaaaaagcucguaguugaaccuugggcucggcccgucgg
uccugggucgggccuuuccuggagaaccgcaugcccuucacugggugugu
cggggaaccaggacuuuuaccgugaacaaaucagaucgcucaaagaaggc
cuaugcucgaauguacuagcauggaauaauagaauaggacgugugguucu
auuuuguugguuucuaggaccgccguaaugauuaauagggacagucgggg
gcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacu
aacuacugcgaaagcauuugccaaggauguuuucauuaaucaggaacgaa
aguuaggggaucgaagacgaucagauaccgucguagucuuaaccauaaac
uaugccgauuagggaucggacgguguuauuuuuugacccguucggcaccu
uacgauaaaucaaaauguuugggcuccugggggaguauggucgcaaggcu
gaaacuuaaagaaauugacggaagggcaccaccagggguggagccugcgg
cuuaauuugacucaacacggggaaacucaccagguccagacacgaugagg
auugacagauugagagcucuuucuugauuucgugggugguggugcauggc
cguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacga
gaccuuaaccugcuaaauagcccguauugcuuuggcaguacgcuggcuuc
uuagagggacuaucggcucaagccgauggaaguuugaggcaauaacaggu
cugugaugcccuuagauguucugggccgcacgcgcgcuacacugacacag
ccagcgaguacucccuuggccggaagguccggguaaucuuguuaaacugu
gucgugcuggggauagagcauugcaauuauugcucuucaacgaggaaucc
cuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuugu
acacaccgcccgucgcuacuaccgauugaauggcucagugaggcuuccgg
acuggcccagggaggucggcaacgaccacccagggccggaaagcuaucca
aacucggucauuuagaggaaguaaaagucguaacaaggucuccguuggug
aaccagcggagggaucauu

...<<<<<.[.((((>>>>><<<<.<<<<<<...<.<...<......<<<
.<<<..<<....<<<...<<.........>>..>>>.>>......<<...
.....<<<..<<..<<....<<<...............<<.....<..<<
<.....>>>..>......>>........<<<<<.......>>>>><...<
<<<<<......[.......<<<<....>>>>..............>>>>>
>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>
>.<<<....<<<......<<<<<<.......>>>>>>..>>>......>>
>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>
.>>.<.<<<..>>>.>...>>>>>>.........<<<....<<<<...>>
>>..>>>..>....>.>....<<<<.<<<<<<..........>>>>>>..
>>>>.....<<..<...........>..>>.........<<<<<((....
..<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>..
.......<<<((.....<.<<...<<<.<<....<<<<<<<<<<<<....
...>>>>>>>>>>>>..<<<..............................
.........>>>....<<<<<<<<.......<<..<<.......>>.<<<
....>>>....>>......>>>>>..>>>.........<<<.<<<<<<<<
<...........].>>>>>>>>>>>>.....>>....<<<<<<.<<...<
<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>
.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>...
.<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>.......
...<<<.<<.<<<..<<<<<<<<.<<<<.....>>>>>>>>>>>>..>>>
...<<..))>>...>>.....>>>.>>>.<<<......<<<<....>>>>
....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<..<<<.
.......<<........>>..........<<<<<<.....<<<<<.....
...<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<
<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>..
..<<<<<.<<..<<<<..<<<<..<<<..........>>>....>>>>..
>>>>.>>....<<<<<<....>>>>>>.......>>>>>....>>>.>>>
.....>>>>>>>.....>>>.>>>......>>>..>>>.....<<<<<<<
......<<.....<<<.<<<<....>>>>.>>>....>>.......>>>>
>>>......<....<<<<<<..........>>>>>>....>.....>>>>
>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>
.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<.<..<..
.<<<<<<<.<<<.<<<<<....>>>>>.>>>.>>>>>>>...>..>.>>.
.>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<.
.>>>>>>>>>>........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7r81 Structure of the translating Neurospora ribosome arrested by cycloheximide
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): K23 H26 N60 G61 S62 R65 H83 S84 K85 K87
• Binding residue (residue number reindexed from 1): K1 H4 N38 G39 S40 R43 H61 S62 K63 K65

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7r81, PDBe:7r81, PDBj:7r81
• PDBsum: 7r81
• PubMed: 34815343
• UniProt: Q7SC06|RS25_NEUCR Small ribosomal subunit protein eS25 (Gene Name=rps-25)