Structure of PDB 7pwo Chain a1 Binding Site BS01

Receptor Information
>7pwo Chain a1 (length=97) Species: 184922 (Giardia lamblia ATCC 50803) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MPVKRRNNGRSKYNCGHTNIVRCQNCHRCVPKDKVIKRFTIRNIVDNTIA
DDVLNACVIQGFAIPKLYNKVQYCVSCSIHNHIVRVRSREDRKIRTP
Ligand information
>7pwo Chain 2 (length=1355) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auccggucgauccugccggagcgcgacgcucuccccaaggacgaagccau
gcaugccucaggacgcggcggacggcucaggacaacgguugcaccccccg
uggcggucgccggacaccgcuggcaacccggcgccaagacgugcgcgcaa
gggcgggccccgggcgagcagcgugacgcagcgacggcccgcccgggcuu
ccggggcaucacccggucggcgcggucgcggcgcgccgagggcccgacgc
cuggcggagaaucaggguucgacuccggagagcgggccugcgagacggcc
cgcacauccaaggacggcagcaggcgcggaacuugcccaaugcgcggcgc
gcggcggcgcgacggggugcgcgcgagucaggcgggcccaccccgacccg
ccagggcaaggcuggugccagcagccgcgguaauuccagcucggcgagcg
ucgcgcggcgcugcugcaguugaaacgcccguaguuggccccccgccgcc
acgaggaaacgggagcgcuccaggcagguuggacccgccgcgugggaccg
cggcgggcccggcgcgccgcggcagccccgaggagagcgggcgggggcac
cgguaccggccggggacgggugaaacaggaugaucccgccgagaccgccg
gccgcgcaggcgccugccaagaccgccucugucaaucaagggcgaaggcc
gggggcuagaaggcgaucagacaccaccguauucccggccguaaacggug
ccgccccgcggccggcgcgcgucccgccggccgcccagggaaaccgggag
gcuccgggcucuggggggaguauggccgcaaggcugaaacuugaaggcau
ugacggagggguacaccagacguggagucugcggcucaaucugacucaac
gcgcgcaccucaccaggcccgcgcgguggugcauggccgcucccagcccg
uggcgcgagccgugcuccauugcgacaacgagcgagaccccggccgcggg
ccgcgggacggcccgcagcgggaggacggcggggcgauagcaggucugug
augcccuccgcccugggccgcacgcgcgcuacacuggcggggccagccgg
cgcccgcgaggacgcgagcccccgccguggccgggaccgcgggcuggaac
gcccccgcgcaccaggaaugucuuguaggcgcccgcccccaccgcgcgcc
ggacgcgucccugccccuuguacacaccgcccgucgcuccuaccgacugg
gcgcugcggcgagcgccccggacgggaagggccgcgagccccagcgccug
gaggaaggagaagucguaacaagguauccguaggugaaccugcggaugga
ucccu
..<<<<<.[..(((>>>>>.<<<<<<<<<..<<<....<......<<<.<
<<..<<<.........>>>......<<........<<<..<<..<<...<
<<<<......<<.....<<<<<<....>>>>>>......>>.....<<..
..<<<.......<.....>..>>>...>>.......>.>>>>..>>>>..
>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>
>...<<<<<<<<....>>>>...>>>>.>>.<<<<<<..........>>>
>>>.<.<<....>>.>...>>>>>>.........<<<....<<<...>>>
..>>>..>.....>>>..........<<<.<<.........>>.>>>..<
<<.<(((...<<<<<.....<<.)))>>.......>>>>>>.>>>..>>>
>>>>>>..........<<<((.....<<<<...<<<.......<<<.<<<
<<<.......<<..<<.......>>........>>.....>>>>>..>.>
>><<<<<<.......>>>.>.>>..........<<<<<<<.....<<<<.
.<<..<<<<<.<<<..<.<......>.>.....>>>.>>>>.>.>>....
...<<....>>...>>>>....>>>>.>>>...>>>...>>>>...<<<<
<<<<...<...<<.<.<.....>.>.>>...>>>>>>>>>.........<
<<.<<..<<<<<<<<<<.<...>.>>>>>>>>>>...<<..))>>....>
>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))..]
<<<<<.<<<<<<<.<<.<<<<<<..<<<.<<<<<<......<<.......
.>>.........<<<<<.<.....<<.<<<..<<.<<<<<<....<<.<<
<<<<....>>>..<<......>>....>>>.>>....<<<<<.<<<<<<.
>>>>>>.....<<<<<.>>>>>.......>>>>>....>>>.>>>.....
>>>>>>>..>.>>>>>...>>.>>>>.>>>.....<<<<<<<.......<
<<.<<....>>.>>>....>>>>>>>......<....<<.<<<<......
>>>>.>>....>.....>>>>>>....<<<<<.<<.......>>.>>>>>
......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<.<<....<<
<<<<<<.<<<..<<<.<<<.........>>>.>>>..>>>.>>>>>>>>.
..>>.>>>>>..>.>>...>.....<<<<<<<<<<..>>>>>>>>>>...
.....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7pwo Cryo-EM structure of the ancient eukaryotic ribosome from the human parasite Giardia lamblia.
Resolution2.75 Å
Binding residue
(original residue number in PDB)		M1 P2 V3 K4 R5 R6 N8 G9 R10 Y13 N14 C15 G16 H17 I20 R28 K32 K34 K37 R38 F39 K70 V75 R85 V86 R87 S88 R89 R92 R95 T96 P97
Binding residue
(residue number reindexed from 1)		M1 P2 V3 K4 R5 R6 N8 G9 R10 Y13 N14 C15 G16 H17 I20 R28 K32 K34 K37 R38 F39 K70 V75 R85 V86 R87 S88 R89 R92 R95 T96 P97
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7pwo, PDBe:7pwo, PDBj:7pwo
PDBsum7pwo
PubMed35100413
UniProtA8BQZ7

[Back to BioLiP]