Structure of PDB 6hcf Chain a1 Binding Site BS01

Receptor Information
>6hcf Chain a1 (length=75) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RDKLNNLVLFDKATYDKLCKEVPNYKLITPAVVSERLKIRGSLARAALQE
LLSKGLIKLVSKHRAQVIYTRNTKG
Ligand information
>6hcf Chain A1 (length=1732) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugacccccuucgcggggggga
ugcgugcauuuaucagaucaaaaccaacccggucaggcggcuuuggugac
ucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucga
acgucugcccuaucaacuuucgaugguagucgccgugccuaccaugguga
ccacgggugacggggaaucaggguucgauuccggagagggagccugagaa
acggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacuccc
gacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggc
ccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauugg
agggcaagucuggugccagcagccgcgguaauuccagcuccaauagcgua
uauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggc
cguccccugccucucggcgccccggggcccgaagcguuuacuuugaaaaa
auuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaaugg
aauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauu
aagagggacggccgggggcauucguauugcgccgcuagaggugaaauucu
uggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuu
cauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucg
uaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauuccc
augacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggg
gaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccac
caggaguggagccugcggcuuaauuugacucaacacgggaaaccucaccc
ggcccggacacggacaggauugacagauugauagcucuuucucgauuccg
ugggugguggugcauggccguucuuaguugguggagcgauuugucugguu
aauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccc
ggucggcguaacuucuuagagggacaaguggcguucagccacccgagauu
gagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcg
cuacacugacuggcucagcgugugccuacccuacgccggcaggcgcgggu
aacccguugaaccccauucgugauggggaucggggauugcaauuauuccc
caugaacgaggaauucccaguaagugcgggucauaagcuugcguugauua
agucccugcccuuuguacacaccgcccgucgcuacuaccgauuggauggu
uuagugaggcccucggaucggccccgccggggugcccuggcggagcgcug
agaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagg
uuuccguaggugaaccugcggaaggaucauua
...<<<<<.{.((((>>>>><<<.<<<<<<.....<<..<......<<<.
<<<...<....<<....<<..........>>...>>.>.......<<...
.....<<<.<....<<....<<<<..........<<.....<<.<<<...
..>>>.>>......>>.........<<<<...<<<<<<....>>>>>>..
.>>>><<..<<<<<......((((.((.<<..<...>.>>....<.....
.>..>>>>>......>>...<<<<..<<<.>>>.>>>>..>.>>>...>>
..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>..
....>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<.......
...>>>.>>...<<....>>.....>>>>>>.........<<<....<<<
.....>>>..>>>..>...>>.......<<<<<<<<<.<<......>>..
>>>>>>.>>>......<<..<...........>..>>.........<<<<
<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>
>.>>>.........<..[[.....<.<<...<<<.<<....<<<.<<<..
>>>.>>>...........<.<<<.>>>>.........<<<<<<.<.....
..<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>...
.......<<.<<<<<<<......)).))))..>>>>>>>.>>......>>
....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>.
.....>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>
>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>.
..>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<......
..>>>>>>>>>.>..>>>...<<..]]>>...>>.....>>>...>.<<<
......<<<......>>>....>>>..)))).}<<<<<.<<<<<<<...<
..<<<<<..<<<.<<<<<<......<<........>>..........<<<
<<......<<<<<........<<.<<<........>>>.>>......>>>
>>...<<.<<<..<<.<<<<<.....<<<.<<<<......>>...<<<..
....>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<.<<<..
>>>..>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........
>>>.....>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>
>>.....<<.<<<................<<<.<<<<....>>>>.>>>.
.............>>>.>>............<<<<<..........>>>>
>...........>>>>>.....<<<<<<<<.......>>>>>>>>.....
.>....>>>>>>>>>>.>>.......<<.<..<<<<.<<....<<<<<<<
<.<<<..<<<<.<<...<<<<<.<<<<<<<<<..>>>>>>>>>...>>>>
>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>........
..<<<<<<<<....>>>>>>>>..........
Receptor-Ligand Complex Structure
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PDB6hcf ZNF598 Is a Quality Control Sensor of Collided Ribosomes.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		L44 N46 R80 G81 S82 R85 R104
Binding residue
(residue number reindexed from 1)		L4 N6 R40 G41 S42 R45 R64
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006364 rRNA processing
GO:0042274 ribosomal small subunit biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0014069 postsynaptic density
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0045202 synapse
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6hcf, PDBe:6hcf, PDBj:6hcf
PDBsum6hcf
PubMed30293783
UniProtG1TDB3|RS25_RABIT Small ribosomal subunit protein eS25 (Gene Name=RPS25)

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