Structure of PDB 8fvy Chain a Binding Site BS01

Receptor Information
>8fvy Chain a (length=96) Species: 941442 (Giardia intestinalis assemblage A) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PVKRRNNGRSKYNCGHTNIVRCQNCHRCVPKDKVIKRFTIRNIVDNTIAD
DVLNACVIQGFAIPKLYNKVQYCVSCSIHNHIVRVRSREDRKIRTP
Ligand information
>8fvy Chain 2 (length=1441) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cauccggucgauccugccggagcgcgacgcucuccccaaggacgaagcca
ugcaugcccgcucaccggacgcggcggacggcucaggacaacgguugcac
cccccgcggcgguccuagccggacaccgcuggcaacccggcgccaagacg
ugcgcgcaagggcgggcgcccgggcgagcagcgugacgcagcgacggccc
gcccgggcuuccggggcaucacccggucggcgcggucgcggcgcgccgag
ggcccgacgccuggcggagaaucaggguucgacuccggagagcgggccug
cgagacggcccgcacauccaaggacggcagcaggcgcggaacuugcccaa
ugcgcggcgcgcgaggcagcgacggggagcgcgcgagcgaggcgggccca
cagcccccgccgcggagccgagggcaagcuggugccagcagccgcgguaa
uuccagcucggcgagcgucgcgcggcgcugcugcaguugaaacgcccgua
guuggccccccgccgccacgaggaaacgggagcgcuccaggcaggcccgu
uggacccgccgcgugggaccgcgcagcgggcgcggcgcgccgcggcagcc
ccgaggagagcgggcgggggcaccgguaccggccggggacgggugaaaca
ggaugaucccgccgagaccgccggccgcgcaggcgccugccaagaccgcc
ucugucaaucaagggcgaaggccgggggcuagaaggcgaucagacaccac
cguauucccggccguaaacggugccgccccgcggccggcgcgcgcguccc
gccggccgcccagggaaaccgggaggcuccgggcucuggggggaguaugg
ccgcaaggcugaaacuugaaggcauugacggagggguaccaccagacgug
gagucugcggcucaaucugacccaacgcgcgcaccucaccaggcccggac
gcgcggaggaccgacagccgggcgcgcuuucgcgaucgcgcgggcggugg
ugcauggccgcucccagcccguggcgcgagccgucugcuccauugcgaca
acgagcgagaccccggccgcgggcgccgcgggacggcccgcgcgagcggg
aggacggcggggcgauagcaggucugugaugcccucagacgcccugggcc
gcacgcgcgcuacacuggcggggccagccggcgcccgcgaggacgcgcgg
agcccccgccguggccgggaccgcgggcuggaacgcccccgcgcaccagg
aaugucuuguaggcgcccgcccccaccgcgcgccggacgcgucccugccc
cuuguacacaccgcccgucgcuccuaccgacugggcgcggcggcgagcgc
cccggacgcgcgaagggccgcgagcccccgcgccuggaggaaggagaagu
cguaacaagguauccguaggugaaccugcggauggaucccu
...<<<<<.{..(((>>>>>.<<<<<<<<<..<<<<<..<......<<<.
<<<..<<.<<<.........>>>>>......<<........<<<..<<..
<<...<<<<..........<<.....<<<<<<....>>>>>>......>>
.....<<....<<<...(((..<.....>..>>>...>>.........>>
>>..>>>>..>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>
>>......>>>...<<<<<<<<....>>>>...>>>>.>>.<<<<<<...
.......>>>>>>.<.<<....>>.>...>>>>>>.........<<<...
.<<<<...>>>>..>>>..>...>>>>>............<<<<<<....
.....>>>>>>.....<<<<<((....<<<<<.....<<..))>>.....
..>>>>>>>>>>..>>>>>>>>>..........<<<[[.....<<<<...
<<<.......<<<.<<<<<<.<.....<<..<<.......>>........
....>>..>..>>>>>..>.>>>..<<.<<<..)))..>>>...>>....
......<<<<<<<.....<<<<..<<..<<<<<.<<<..<.<......>.
>.....>>>.>>>>.>.>>.......<<....>>...>>>>....>>>>.
>>>...>>>...>>>>...<<<<<<<<...<...<<.<.<.....>.>.>
>...>>>>>>>>>.........<<<.<<..<<<<<<<<<<.<.....>.>
>>>>>>>>>...<<..]]>>....>>.....>>>.>>>.<<<......<<
<<....>>>>....>>>..)))..}<<<<<.<<<<<<<..<<..<<<<<.
.<<<.<<<<<<......<<........>>.........<<<<<.<....<
<<<<<......<<<.<<<.......>>>.>>>....>>>>>>...<<.<<
<..<<.<<<<<<....<<.<<<<<<....>>>....<<......>>....
>>>.>>....<<<<..<<<<<<...>>>>>>.....<<<<<....>>>>>
........>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...
>>.>>>>.>>>.....<<<<<<<.....<.<<<.<<....>>.>>>..>.
...>>>>>>>......<....<<.<<<<......>>>>.>>....>....
.>>>>>.....<<<<<.<<.......>>.>>>>>......>>...>>>>>
>>>>>.>>....<..<<.<.<<<<<.<<....<<<<<<<<.<<<..<<<.
<<<...........>>>.>>>..>>>.>>>>>>>>...>>.>>>>>..>.
>>...>.....<<<<<<<<<....>>>>>>>>>........
Receptor-Ligand Complex Structure
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PDB8fvy The Giardia lamblia ribosome structure reveals divergence in several biological pathways and the mode of emetine function
Resolution2.94 Å
Binding residue
(original residue number in PDB)		P11 K13 R14 R15 N16 N17 G18 R19 Y22 N23 C24 G25 H26 K43 K46 R47 F48 K79 V84 S85 I88 H89 V95 R96 R101 R104
Binding residue
(residue number reindexed from 1)		P1 K3 R4 R5 N6 N7 G8 R9 Y12 N13 C14 G15 H16 K33 K36 R37 F38 K69 V74 S75 I78 H79 V85 R86 R91 R94
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8fvy, PDBe:8fvy, PDBj:8fvy
PDBsum8fvy
PubMed38242118
UniProtA8BQZ7

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