Structure of PDB 7ttu Chain a Binding Site BS01

Receptor Information

>7ttu Chain a (length=110) Species: 1280 (Staphylococcus aureus)

KIDKNKVRLKRHARVRTNLSGTAEKPRLNVYRSNKHIYAQIIDDNKGVTL
AQASSKTATKVELATKVGEAIAKKAADKGIKEIVFDRGGYLYHGRVKALA
EAARESGLEF

Ligand information

>7ttu Chain 1 (length=2684)

uaaguuauuaagggcgcacgguggaugccuuggcacuagaagccgaugaa
ggacguuacuaacgacgauaugcuuuggggagcuguaaguaagcuuugau
ccagagauuuccgaauggggaaacccagcaugaguuaugucauguuaucg
auaugugaauacauagcauaucagaaggcacacccggagaacugaaacau
cuuaguacccggaggaagagaaagaaaauucgauucccuuaguagcggcg
agcgaaacgggaagagcccaaaccaacguugggguuguaggacacucuag
uuacaaaggacgacauuagacgaaucaucuggaaagaugaaucaaagaag
guaauaauccuguagucgaaaauguugucucucuugaguggauccugagu
acgacggagcacgugaaauuccgucggaaucugggaggaccaucuccuaa
ggcuaaauacucucuagugaccgauagugaaccaguaccgugagggaaag
gugaaaagcaccccggaaggggagugaaauagaaccugaaaccgugugcu
uacaaguagucagagcccguuaaugggugauggcgugccuuuuguagaau
gaaccggcgaguuacgauuugaugcaagguuaagcaguaaauguggagcc
guagcgaaagcgagucugaauagggcguuuaguauuuggucguagacccg
aaaccaggugaucuacccuuggucagguugaaguucagguaacacugaau
ggaggaccgaaccgacuuacguugaaaagugagcggaugaacugagggua
gcggagaaauuccaaucgaaccuggagauagcugguucucuccgaaauag
cuuuagggcuagccucaagugaugauuauuggagguagagcacuguuugg
acgagcgaauucagacaaacuccgaaugccaauuaauuuaacuugggagu
cagaacaugggugauaagguccguguucgaaagggaaacagcccagacca
ccagcuaaggucccaaaauauauguuaaguggaaaaggauguggcguugc
cacagagugacacugcgccgaaaauguaccggggcuaaacauauuaccga
agcuguggauugucgacaaugguaggagagcguucuaagggcguugaagc
augaucguaaggacauguggagcgcuuagaagugagaaugccggugugag
uagcgaaagacgggugagaaucccguccaccgauugacuaagguuuccag
aggaaggcucguccgcucuggguuagucggguccuaagcugaggccgaca
ggcguaggcgauggauaacagguugauauuccuguaccaccuauaaucgu
aucgauggggggacgcaguaggauaggcgaagcgugcgauuggauugcac
gucuaagcaguaaggcgcugagcugugauggggagaagaccuucgagucg
uugauuucacacugccgagaaaagccucuagauagaaaauaggugcccgu
accgcaaaccgacacagguagucaagaugagaauucuaaggugagcgagc
gaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaag
gggugcucuuuaggguuaacgcccagaagagccgcagugaauaggcccaa
gcgacuguuuaucaaaaacacaggucucugcuaaaccguaaggugaugua
uaggggcugacgccugcccggugcuggaagguuaagaggagugguuagcu
ucugcgaagcuacgaaucgaagccccaguaaacggcggccguaacuauaa
cgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacga
aaggcguaacgauuugggcacugucucaacgagagacucggugaaaucau
aguaccugugaagaugcagguuacccgcgacaggacggaaagaccccgug
gagcuuuacuguagccugauauugaaauucggcuuucuaacccgcaccac
uuaucguggugggagacagugucaggcgggcaguuugacuggggcggucg
ccuccuaaaagguaacggaggcgcucaaagguucccucagaaugguugga
aaucauucauagaguguaaaggcauaagggagcuugacugcgagaccuac
aagucgagcagggucgaaagacggacuuagugauccggugguuccgcaug
gaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuua
ucucccccaagaguucacaucgacggggagguuuggcaccucgaugucgg
cucaucgcauccuggggcuguagucggucccaaggguugggcuguucgcc
cauuaaagcgguacgcgagcuggguucagaacgucgugagacaguucggu
cccuauccgucgugggcguaggaaauuugagaggagcuguccuuaguacg
agaggaccgggauggacauaccucugguguaccaguugucgugccaacgg
cauagcuggguagcuauguguggacgggauaagugcugaaagcaucuaag
caugaagccccccucaagaugagauuucccaacuucgguuauaagauccc
ucaaagaugaugagguuaauagguucgagguggaagcauggugacaugug
gagcugacgaauacuaaucgaucgaagacuuaau

<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......
<<<<<<.[...((.>>>.....<<<<<<<..<<.))...]..>>.....>
>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<
<<<<<<.........>>>>>>>.>>.>>....<<<<<......<<....>
>.......>>>>.>.........<<....>>..<<<<<......<<....
.>>.....>>>>>..(((....<<<<..>>>>......<<<<<.......
........<.<<<<<<<.<<<...<<<<<......>>>>>((......<<
<.....))>>>...>>>...>>>>>>>..>.........>..>>>>....
.<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..
)))......]].>>>>>>>.]]...............<<....>>....]
].........<<<<....>>>>.............}....>>>>>>>>>>
>.......<<<<..<<<<......>>>>..>>>>...<.<........>.
>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>
...<<....>>..<<<<.....>>>>.....>>>>>.>>>>>>>..<<.<
...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>
.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>.
..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<
<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<
<........>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>
..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<
<.<<<...<<<(((.....<<<<<<...........<<..<<<<.<.<<.
.......>>.>.>>>>.>>...........))).....>>>>>>.>>>..
.>>>>>>><<<<<..>>>>>....>>>>>><.<<<<<<<.<<......<<
<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><....
..<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<
<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....
>>>...>>>...>>...<<<<<........>>>>>))<<<<<<.......
.<<...<<<<....<<<<...<<...<......<<<.........>>>..
.<....<<<<...<<..>>...>>>>.....>..................
.>....>>...>>>>.........>>>>..>>.......>>>>>>>>>>.
.>>.....<<......>>>>>>>.<<<.......>>>..>>>>..<<<<.
...<<<<<<<<.<<...............<<<<<....<<..>>.....>
>>>><<<<<<<.<<<<....>>>>.>>>>>>>............<<<<<<
<<<..<<<.........>>>..<<<<<<<.....<<......>>......
.>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<..<<...<<<<<<.<<.
...>>..>>>>>>...>>..>>>>>>>>>..>>>>><<<<<<.......>
>>>>>........<...........<<<<<<.....>>>>>>.....>..
..>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>.>.....>..
...<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[
[<<<<..<<<<<.<<<<<<<<..<<<<......>>>>....<<.<<<<<<
.....>>>>>>>>......>>>>>>>>..>>>>>..<<<<.....>>>><
<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.....
..>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<....
..>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>
>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<
.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<
<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>
>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>...
.]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<.......
........>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<....>>>>
>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>
>>>....>>>.>>>>.......>>>>>>>.<<<....>>>....<<<<<<
<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>.
..>>>..>>>>>.>>>...>>>>....>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7ttu A Structurally Characterized Staphylococcus aureus Evolutionary Escape Route from Treatment with the Antibiotic Linezolid.
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): R14 R17 L22 F94 R96 Y101 R113 F119
• Binding residue (residue number reindexed from 1): R11 R14 L19 F85 R87 Y92 R104 F110

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0008097 5S rRNA binding
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7ttu, PDBe:7ttu, PDBj:7ttu
• PDBsum: 7ttu
• PubMed: 35736238
• UniProt: Q2FW22|RL18_STAA8 Large ribosomal subunit protein uL18 (Gene Name=rplR)