Structure of PDB 7qi6 Chain a Binding Site BS01

Receptor Information
>7qi6 Chain a (length=100) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TYSPLPDDYNCNVELALTSDGRTIVCYHPSVDIPYEHTKPIPRPDHDQVL
KTRLEEKVEHLEEGPMIEQLSKMFFTTKHRWYPHGRYHRCRKNLNPPKDR
Ligand information
>7qi6 Chain A (length=1558) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagc
caaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcg
caauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcaua
auauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaa
auaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcu
accuaagaacagcuaaaagagcacacccgucuauguagcaaaauaguggg
aagauuuauagguagaggcgacaaaccuaccgagccuggugauagcuggu
uguccaagauagaaucuuaguucaacuuuaaauuugcccacagaacccuc
uaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuug
gacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauag
uaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacaccca
cuaccuaaaaaaucccaaacauauaacugaacuccucacacccaauugga
ccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaa
acauucuccuccgcauaagccugcgucagauuaaaacgaacugacaauua
acagcccaauaucuacaaucaaccaacaagucauuauuacccucacuguc
aacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaa
cucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcauc
accaguauuagaggcaccgccugcccagugacacauguuuaacggccgcg
guacccuaaccgugcaaagguagcauaaucacuuguuccuuaaauaggga
ccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccag
ugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaa
gacccuauggagcuuuaauuuauuaaugcaaacaguaccuaacaaaccca
cagguccuaaacuaccaaaccugcauuaaaaauuucgguuggggcgaccu
cggagcagaacccaaccuccgagcaguacaugcuaagacuucaccaguca
aagcgaacuacuauacucaauugauccaauaacuugaccaacggaacaag
uuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaau
aggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgc
uauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguuc
agaccggaguaauccaggucgguuucuaucuacuuucaaauuccucccug
uacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccg
uaaaugauaucaucucaacuuaguauuauacccacacccacccaagaaca
ggguuugu
<<<.......<<<<....................................
.<......>...............<<.....>>.............>>.>
>.............<<....>>......................>>>...
........<<<.......>>>...<.<........>.>.<<<<<<.....
....<<<.<<..<<....>>...>>.>>>...<<.<...<<<<.<.....
<<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>
....>>>.>>>>>...<<.......>>......>.>>>>......>.>>.
.<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<......
....>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>
>>>.<.<<<......>>>.>..<<<.<<<...<..............<..
..<<<.........>>>....>.......<<<......>>>.........
...........................>...>>>>>>........>>>>>
>...<<<<<......>>>>>.........>>>>>><......<<..<<<.
...>>><<<<..<<<<........<<<<<.<<.....>>.>>>>>.....
.<<<...<<<<.......................>>>>.......>>>..
...<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<...
......<......<<<<<<..<<<.........>>>...<<<<<<.....
........>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><<<<
<<......>>>>>>........<...........<<<<<<.....>>>>>
>.....>....>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>
>.....>.....<<<<<........>>>>>.......<<..<<<.<<...
...<<<<.<<<<<<..<<<<<.<<<<<<<<...............<<<..
..>>>................>>>>>>>>>>>>>..<<<<.....>>>><
<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>.
.>>>...........>>.........<<<....>>>............>>
>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>
>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>
>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>...
.<<<<<<<....>>>.>>>>....>>..>>>.>>...<.<<<.<<<....
.............>>>.>>><<<<<...<<<....>>>.>>>>>......
<<<................>>>......>..........<<<<.......
>>>>....
Receptor-Ligand Complex Structure
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PDB7qi6 Structure of mitoribosome reveals mechanism of mRNA binding, tRNA interactions with L1 stalk, roles of cofactors and rRNA modifications.
Resolution2.98 Å
Binding residue
(original residue number in PDB)		K120 H121 Y124 P125 H126 G127 R128 Y129 H130 R133 K134 N135 P138
Binding residue
(residue number reindexed from 1)		K78 H79 Y82 P83 H84 G85 R86 Y87 H88 R91 K92 N93 P96
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
GO:0032543 mitochondrial translation
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005762 mitochondrial large ribosomal subunit
GO:0005763 mitochondrial small ribosomal subunit
GO:0005840 ribosome
GO:0005886 plasma membrane
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7qi6, PDBe:7qi6, PDBj:7qi6
PDBsum7qi6
PubMed38769321
UniProtQ9Y6G3|RM42_HUMAN Large ribosomal subunit protein mL42 (Gene Name=MRPL42)

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