Structure of PDB 7po4 Chain a Binding Site BS01

Receptor Information

>7po4 Chain a (length=100) Species: 9606 (Homo sapiens)

TYSPLPDDYNCNVELALTSDGRTIVCYHPSVDIPYEHTKPIPRPDHDQVL
KTRLEEKVEHLEEGPMIEQLSKMFFTTKHRWYPHGRYHRCRKNLNPPKDR

Ligand information

>7po4 Chain A (length=1145)

gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagc
caaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcg
caauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcaua
auauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaa
auaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcu
accuaagaacagcuaaaagagcaagauuuauagguagaggcgacaaaccu
accgagccuggugauagcugguuguccaagauagaaucuuaguucaacuu
uaaauuugcccacagaacccucuaaauccccuuguaaauuuaacuguuag
uccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagaga
guaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaaga
aagcguucaagcucaacacaucccaaacauauaacugaacuccucacacc
caauuggaccaaucuaucacccuauagaagaacuaauguuaguauaagua
acaugaaaacauucuccuccgcauaagccugcgucagauuaaaaugaacu
gacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuaccc
ucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaagu
aaaaggaacucggcaccuguuuaccaaaaacaucaccucuagcaucacca
guauuagaggcaguucagcugucucuuacuuuuaaccagugaaauugacc
ugcccgugaagaggcgggcauaacacagcaagacgagacccuauggagcu
uuaauuuauuaaugcaaacaguaccaaaccugcauuaaaagcaguacaug
cuaagacuucaccagucaaagcgaacuauccaauaacuugaccaacggaa
caaguuacccuaggcuaucuacuuucaaauuccucccuguacgaaaggac
aagagaaauaaggccuacuucacaaagcgccuuccccuaaaugauaucau
cucaacuuaguauuauacccacacccacccaagaacaggguuugu

<<<.......<<<<....................................
.<......>...............<<.....>>.............>>.>
>.............<<....>>......................>>>...
........<<<.......>>>...<.<........>.>.<<<<<<.....
....<<<.<<..<<....>>...>>.>>>...<<.<..<<<<<.<.....
<<<<<.<<<..<<.......>>....>>>.>>>>>...<<.......>>.
.....>.>>>>...>..>.>>..<<<<<<....<<<<....>>>><<<.<
<<<<<<<<<.....<<..........>>.....>>>>>>>>>>..>>>.<
<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<<
<...<...................<<<.........>>>...........
.<<<......>>>......................>...>>>>>>.....
...>>>>>>...<<<<<......>>>>>.........>>>>>><......
<<..<<<....>>><<<<..<<<<........<<<<<.<<.....>>.>>
>>>......<<<...<<<<.......................>>>>....
...>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<
<<.<<.......<<...<<<<<.....>>>>>...<<<<<<.........
....>>>>>>.......>>...>>.>>>>>>>>>>>>.>>.....>....
.<<<<<........>>>>>.......<<..<<<.......<<<.<.<<<<
........<<<<<<<<....<..>......>>>>>>>>...........<
<<..<<<<.....>>>>..>>>........<<<....>>>..........
..>>>>...>>>>....>>>.>>...<.<<<.<<<...............
..>>>.>>><<<<<...<<<....>>>.>>>>>.....<<.<........
....>.>>.......>..........<<<<.......>>>>....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7po4 Mechanism of mitoribosomal small subunit biogenesis and preinitiation.
• Resolution: 2.56 Å
• Binding residue (original residue number in PDB): K120 H121 Y124 P125 H126 G127 R128 Y129 H130 R133 K134 N135 P138 P139
• Binding residue (residue number reindexed from 1): K78 H79 Y82 P83 H84 G85 R86 Y87 H88 R91 K92 N93 P96 P97

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005763 mitochondrial small ribosomal subunit
• GO:0005840 ribosome
• GO:0005886 plasma membrane
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7po4, PDBe:7po4, PDBj:7po4
• PDBsum: 7po4
• PubMed: 35676484
• UniProt: Q9Y6G3|RM42_HUMAN Large ribosomal subunit protein mL42 (Gene Name=MRPL42)