Structure of PDB 7a5h Chain a Binding Site BS01

Receptor Information
>7a5h Chain a (length=82) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TYSPLPDDYNCNVELALTSDGRTIVCYHPSVDIPYEHTKPIPREEGPMIE
QLSKMFFTTKHRWYPHGRYHRCRKNLNPPKDR
Ligand information
>7a5h Chain A (length=1457) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcuaaaccuagccccaaacccccaccuuacuaccaaaccuuagccaaacc
auuuacauaaaguauaggcgauagaaauugggcgcaauagauauaguacc
gcaagggaaagaugaaaaaaccaagcauaauauagcaaggacuaaccccu
auaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagcca
aagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaagagca
cacccgucuauguagcaaaauagugggaagauuuauagguagaggcgaca
aaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguuc
aacuuuaaauuugcccacagaaccaaauccccuuguaaauuuaacuguua
guccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagag
aguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaag
aaagcguucaagcucaacacaaaaaucccaaacauauaacugaacuccuc
acacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguau
aaguaacaugaaaacauucuccuccgcauaagccugcgucagcaacugac
aauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccuca
cugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaa
aggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucua
gcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacgg
ccgcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaaau
agggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuua
accagugaaauugaccugcccgugaagaggcgggcauaacacagcaagac
gagaagacccuauggagcuuuaauuuauuaaugcaaacaccugcauuaaa
aauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguaca
ugcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuuga
ccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagagu
ccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccg
auggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccuac
gugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuua
uuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcg
ccuucccccguaaaugauaucaucucaacuuagauacccacacccaagaa
caggguu
<<<.......<<<<...............................<....
..>...........<<.....>>.......>>.>>.............<<
....>>.................>>>...........<<<.......>>>
...<.<........>.>.<<<<<<.........<<<.<<..<<....>>.
..>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<...>>>.
..<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.....
..>>......>.>>>>......>.>>..<<<<<<....<<<<....>>>>
<<<.<<<<<<<<<<.....<<......>>.....>>>>>>>>>>..>>>.
<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<
<<...<...................<<<.........>>>..........
..<<<......>>>..........................>...>>>>>>
........>>>>>>...<<<<<......>>>>>.........>>>>>><.
.....<<..<<<....>>><<<<..<<<<........<<<<<...>>>>>
......<<<...<<<<.......................>>>>.......
>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.
<<.........<......<<<<<<..<<<.........>>>...<<<<<<
.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>
><<<<..........>>>>........<...........<<<<<<.....
>>>>>>.....>....>>>....>>.>>>>.....>..>>.>>>>>>>>>
>>>.>>.....>.....<<<<<........>>>>>.......<<..<<<.
<<......<<<<.<<<<<<..<<<<<.<<<<<<<<......>>>>>>>>>
>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<....
.<<<..<<<<.....>>>>..>>>....>>.........<<<....>>>.
...........>>>>..>>>>>>.......<<<..<.<<<<<<...<<..
.....>>...>>>>>>...>.>>.>.......<<<<<..<<<<<..<<.<
<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..
....>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>..<
<<.<<<.................>>>.>>><<<<<...<<<....>>>.>
>>>>......<<<................>>>.........<<<<.....
..>>>>.
Receptor-Ligand Complex Structure
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PDB7a5h Elongational stalling activates mitoribosome-associated quality control.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		K120 H121 Y124 P125 H126 G127 R128 H130 R133 K134 P138
Binding residue
(residue number reindexed from 1)		K60 H61 Y64 P65 H66 G67 R68 H70 R73 K74 P78
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
GO:0032543 mitochondrial translation
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005762 mitochondrial large ribosomal subunit
GO:0005763 mitochondrial small ribosomal subunit
GO:0005840 ribosome
GO:0005886 plasma membrane
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7a5h, PDBe:7a5h, PDBj:7a5h
PDBsum7a5h
PubMed33243891
UniProtQ9Y6G3|RM42_HUMAN Large ribosomal subunit protein mL42 (Gene Name=MRPL42)

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