Structure of PDB 7a08 Chain a Binding Site BS01

Receptor Information

>7a08 Chain a (length=360) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DKLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNT
GSYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKRIPRGNP
LSHFLEGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLL
IRNPEEISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYL
VPKNAKDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKEC
LKLMKYLLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSS
CFDKLLAFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYER
NNGFPIFDKL

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

7a08 Chain a Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7a08 Structural basis for sequestration and autoinhibition of cGAS by chromatin.
Resolution	3.11 Å
Binding residue (original residue number in PDB)	C392 R394
Binding residue (residue number reindexed from 1)	C245 R247
Annotation score	1

Enzymatic activity

Enzyme Commision number

2.7.7.86: cyclic GMP-AMP synthase.

External links

PDB	RCSB:7a08, PDBe:7a08, PDBj:7a08
PDBsum	7a08
PubMed	32911480
UniProt	Q8C6L5\|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)

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