Structure of PDB 6ywx Chain a Binding Site BS01

Receptor Information

>6ywx Chain a (length=161) Species: 367110 (Neurospora crassa OR74A)

QSTANRTKRMLNIPPHESFLNVPVEGDRIIFNPPSSEASVYHTPFKFLPR
SDPRRRANIYKLFDLPPVLYNPTKSYNVTPEQVEEIRELRAKDPKKYSVT
YLSNKYNCTKVFIMMCTQAPREHQEQHKLARARTAENWGPRRAAAKLDAR
RRKEMLHRGEI

Ligand information

>6ywx Chain A (length=2838)

guaauggauauaaagcuuauguuuauauauauauauaaguauauaaagag
acuacuaccaauagcuacacuauguauuaaggagaguauaacuuaauuua
uguuuaugauagagguuaucaacauaugaacucuuagagaaauuacuuaa
uaaacgaagugaauugaaauaucuuauuaacuucaggaaaagaaaucaaa
cgagauucuaugauuagugugaacgaaaauagagcagccuauuaaaauaa
guaaaauggcuuuaaagcuguuugaauauuguggggaaccuuccucaaag
gcuaaauauaauacaugaguuacagagaaaaguaccgugagggaaagcuu
ugaaauaguaguuuuauaagcagcucaagcaauaagaaagcgagagcgua
ccuuuugcauaaugggucaccaaguuaauuuuagaugcgagcgaauuaga
ugugcauaguuaaaccgaucauuaaaauaaugaauagugucuaaaguuag
acccgaagccuggugaucuuacuauagucaggacuauaaagguccgaacg
gguuaucguugcaaagauauccgaagaacuaugguaagcgagugaaagac
aacacugacuaggauagcugguuuucugcgaaaccuauaauaguaggcaa
uuuaaguaacaucuuaguagguacagaacuuaaucucagacaagauguag
auuuucauaccuagguaugaaaugcauuuuuuuuuguauacaucggggga
ucgugaagauuuuaucggugaguauguagacucggaaugacaaagaugaa
ucuugaauaaucagacauagaaugauaagguuguaugucaaaagggaaac
agcccagaacaagaguuaagguuccaaaauuauuauuaagugaaauaaag
aaaguuuuuauauaagucgacaagaagaugggcuuggaagcagccauaau
uuaaagaucucguaacagagcacuuguuaaaucuuaaaagcaucgaaaau
uuaacggaucuaaauaauauaccgaaaccuuguccauauguaacauuagu
aauaauauuaauguuauuugaugggguagcagaacguugagugaaucuua
gauuuuuuuuuuauaacuaaauauagaugauaacucaagugagaauggug
acaugaguaacaaaaaagaguuuaagguaccuaaaagguaucuuagaguc
ucgccuaaagcuuauggcuacgucaaguaacggccucuaaguuuauaauc
ugaagauuaugacgaugagaaaacuuugguaccaacauuuaaaagugaaa
auugugcaggaaggauaaaccguaccuagaaucugaaacaaguaagcuag
uagagaauacgaaggcgugaaugagauaacaaucauaaaggaacucggca
aacuaacuaccguaacuuagggauaaggagagcucauuagucucgaacga
guaaaaaggaagaagcauggaauauuguuguacgacuguuuaauuaaaac
aaagcacuuugcaaaaagacgauaagucuaaguauugagugugauuucug
cccgaugccggcugguuaacgaauuuucuaaauugaaaaaaaauuugguu
ucagaggaacccccgguuaauggcggccuuagcgugaggguccuaaggua
gcgaaaugccuuggccguuaaaugcggucuugcaugaaugauguaacgau
acaacagcugucucuaugauugacucagugaaauuggaauaacugugcag
auacaguuuaccucuaguuagacgagaagacccuaugcagcuuuacuguu
acuaauuauugaauacgauucugaaaauuuccaguguaaaagguaaucga
uaagauauaauugaaacaccuuuauuuuucuaucguauuauuaaaccuua
aauuaaggaacaauuguuagaagacaguuuaugcggggcacaggccccau
aaagaguaaaugggugugucuaaaauguuugcaauuuuuuauaguauaua
ucaaaucaucuuuaugcuauucauagaccuuggguacaguauaaaaauua
uauauguauuaauuuacauauauuuuuucuaagaaauuagguaagauuuu
guuuauagagaaauuagauguaaaaaaaaaaucuuaugagggcggauccg
cuucuaauauuuuuuuguaguuauuauuauaauaauaaucauguuuauua
cuuaaaaagcuuaauggcuuaaucuugccuuacuguuugauuaacaacaa
aucuuacagucgcguaagcggggcauaggaucacaagauacaaaaaggaa
agaucuuggauuuuuggaaaagcuacgcuagggauaacaggcuaauuugc
gcaagaguguacaaaaugagugcgcgguuuggcaccuccggcuugacuaa
uccucauggaugcagaaacuauguaggguacgacuguucgucgauuaaaa
aguuacaugagcuggguuaaauacgucgugagacaguaugguuucuaucu
ucuagagggaauuagaauauaauaaggauuaaccuuuguacgaaaggaac
augggguacuauuguuaacaguuuuauuaaccucugguuuaccuguuguu
uaugugccuuagggauguuaccgucacuugaguaaauacaauagcauaag
cauggcaggaaagcuaaguuagucaaaaauaagugcugaaagcauauagg
cacgaaauuuaccuuaagauauuucuuaaauauacguaagaaaauauuac
guuaauaggcuuaguuuguaauaaucuagagauuuuaaggaacuaaguac
uaauuuuauaaaaaacugaaugauuaauauaucuuaca

<<<<..<<<<<<.......<<<<<<<<<..>>>>...<<<.......<<<
<<<<<<<......<<.....<<<<<<<<..<<<<<<.....>>.....<<
<<<<................>>>>>>....>>>>..<<....>>......
....<<<<<<.....<<....>>......>>>>>.>.........<<...
.>>..<<<<<<.....<<....>>....>>>>>>..<<............
...<<<<<<<<....>>>>>>>>........<<<<<..[[[[>>>>>...
>>.......>>>>>>>>.................<<....>>....>>..
.....>>>>>>>>>>.......<<<<..<<.........>>..>>>>...
<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<.......
..>>>...<......>..<<<<<.....>>>>>...>>>>>>>>>>>>>.
.<<.<..<<<<<<<.....<<<<<<<<<..<<<<<....>>.>>>...<<
<..<<<<........>>>>.>>>....>>>>>>>>>.....<<.....>>
.......>>>>>>.>..>.>>..<<<<<<....<<<<<....>>>>>..<
<<<<<<...<<<<<<.<<.....<<<...<..<<<<<<.<<<<<<<<..<
..<<<<<<<<<..>>>>>>>>>>.>>>>.....>>>>.....<<<<.<<<
<<.....>>>>>..>>>>>>>>.>>..>..>>.>.....>>.>>>>>>..
.>>>>>>>.....<<<<<<.<<<......>>>.>>>>>>....<<<....
..>>>...<<<<<.<<...<<<(((.....<<<<<<.....<<......<
<..<<<<<<<........<<<<<<.<....<<<<.......>>>>....>
........<<<......>>>..>>>>>>......>>>>>>>.>>......
.....)))>>...>>>>>>.>>>...>>>>>>><<<<..<<<<<<<<<<<
<....>>>>>>>>>>>>...>>>>....>>>>>>..<<<<<<..<<<...
.<<..<<..<<...>>..>>..>>....>>>.>>>>>>........>>>>
>><......<<.....<<<.<<<<<<<<<<<.....>>>>>>>>>>>.>>
><<<<<...<<<<<.<<........((...<<<.<<<...<<<.<<<<<<
<..>>>>>>>>>>...>>>....)).........<<<.<<..(((((..>
>.>>>..............>>>..>>......<<......>>>>>>>..<
<<.....>>>..>>>>>....<<<<....<<<<<<<<.<<.........<
......<<.<<....<<..>>.....>>>>..<<<.<<...<<<<..>>>
>....>>.>.>>.............<<<<<<<<<..<<<.........>>
>..<<<<<<.......<<<<.....>>>>.......>>>>>>....<<.<
<<..<<<<<<<..<<....<.......<<<<<<<.......>>>>>>>..
.....>....>>>>>>>..>>>>><<<<<........>>>>>........
<...........<<<<<<.....>>>>>>.....>....>>.....>>.>
>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<.....
...>>>>>..<<<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.
.<<<<<.<<..<<<<<<<<...<<<<<...........<<<<<<.<<<..
...>>>...........>>>>>>..>>>>>.>>>>>>>>......<<<<.
....>>>>....>>.>>>>>...>>>>>...<<.......>>.<<<<<<.
..........>>>>.>>..<<.....<.......<<<..<<<<...>>>>
..>>>.>..........<<<<<<.......>>>>>>.............<
<<<<<<<<......>>>>>>>>>................<<<<<<<....
.<<<<.........>>>>.<<<<..<<<<<<<.<<<.<..<<<<<..>>>
>>.>>>>.>>>.>>>>...<<<<<<<<<..>>>>>>>>>........>>>
>......<<<...(((>>>...>>>>>>>...<<<<..<<<.........
>>>..>>>>.<<<....>>>.>>))).......<<<<<<.<...]]]]..
.>>>>>>>............>>>>..>>>>>>.......<<<<.<...<<
<<<...<.........>...>>>>>....>>>>.>...<<<<.<<<<<..
.<<<<<<<<.........>>>>>..>>>..<<<<.....>>>>.......
>>>>..>...>>>.>.....<<<<<<<....>>>.>>>>....>>..>>>
.>>>>>>>.....<<<<<<...<<<<<...<<<<<...............
>.>>......<<<<<..>>>>>>>.<<<<<<...<<<<...<<<<<<<<<
<<<<<.<<<..>>>...<<<<...)))))..>>>>........>>>>>>>
>>..>>>>>...>>>>.>>>>>>..<<<.<..<<<<<...........>>
>>>...>>>>.>>>>>...>>>.>>>....<<<.<<<<<.......>>>>
>....<<<<<<<<<<<<.....<<<<....>>>>....>>.>>>>>>>.>
>>.....>>>....>>>>>>>>.....>>>>>>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6ywx Analysis of translating mitoribosome reveals functional characteristics of translation in mitochondria of fungi.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): Q41 A44 R46 K48 R49 M50 N52 P54 P55 Y134 K138 S139 Y140 V142 R154 S162 V163 T164 N171 C172 K174 V175 F176 M178 M179 Q182 A183 R185 Q188 E189 H191 K192 R195 T198 N201 W202 G203 R205 R206 A209 K210 R214 K217
• Binding residue (residue number reindexed from 1): Q1 A4 R6 K8 R9 M10 N12 P14 P15 Y70 K74 S75 Y76 V78 R90 S98 V99 T100 N107 C108 K110 V111 F112 M114 M115 Q118 A119 R121 Q124 E125 H127 K128 R131 T134 N137 W138 G139 R141 R142 A145 K146 R150 K153

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Cellular Component

• GO:0005739 mitochondrion
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6ywx, PDBe:6ywx, PDBj:6ywx
• PDBsum: 6ywx
• PubMed: 33056988
• UniProt: Q1K6U7|RM20_NEUCR Large ribosomal subunit protein mL58 (Gene Name=mrpl20)