Structure of PDB 6az3 Chain a Binding Site BS01

Receptor Information
>6az3 Chain a (length=125) Species: 5661 (Leishmania donovani) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SHHMKIKDLREKSKDDLLKTLTEYKKELSQLRVVQQTGGAETRLGRIRPI
RKSIARILTVLNQNERSNLKMFYADRKLRCKTPKVLRAKLTHRRRLALKE
NEKNRKTSRQMRQAHKFPKRVYAVK
Ligand information
>6az3 Chain 1 (length=1620) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agaccugaguguggcaggacuacccgccgaacuuaagcauauuacucagc
ggaggaaaagaaaacaaccgugauucucucagugagcggcgagcgaagag
ggaacgaacucguugccgaaucgggucuuacaaggccuugaguuguggca
caaauaucauuucgugguuggugcaggaguggcgaaauucaagcgcaaag
caaacccguugcugaauacaacccuucaugugaguauugagccaaagaag
guguuagcccauugagccauaaaccugagcgccucaugaacaagcgagua
gcacuguuugggaaugcagugucaaguggcagguauuugucugccaaagu
uaaauacagaguaggaagaccgauagcgaacaaguagcgugagcgaaagu
uugaaaagcacuuuggaaagagagugaaauagaaccugaagucgugacaa
agacaauggaaguaccuccauuucaacggccagaaccagcccuacugcau
uauccugucgggggucaaaauccggcgggcaagaagugcaagaagggucu
uggugaaaugagcggaguauuugagcugugcacggcgcgcacgcacucuu
cuccgugaugcuccauguuggcgaugaaauggggugcccccacccgucuu
gaaacacggaccaaggagucaaacagacgcgcaagggaggagauaugguu
gccaguacuuucucguacugaaagggagaugcaaaaugcaucuguggugu
gcacacgucauuugcccaacaccgaccggcccuccguggguugcguugga
gugugccuguuuggacccgaaagguggugaacuaugccugaacaagguga
agcccggggaaacccagguggaggccuguagcgaugcugacgugcaaauc
gcucguaugauuuggguaucggagcgaaagacucaucgaaccaccuagua
gcugguucacaucgaaguuucccucaggauagcuggugcuaguagaagua
uugugcgguaaagcaaaugauuagaggcauugggaccuauucucaaacuu
uaaaugugcaaacaaaccggccuuagccaacugcaaggccggaaagaaaa
gaauuagaggcaccaagugggccuucuucgguaagcggagcaggcgaugc
ggaaugaaccgcuuagggauauguggcgucaaaacuuaugggcucauucu
cgauacguaaaggguguugguggauauccaccggccccgaaaauggauga
cgcuuaagcccaauuagugauugcccauuauuccuuugguaagggcggaa
acaaaggagaaaguguagcccuuccgauguagauguggccuggagguuag
gacgaagcuuauggcgugagccuaagauggaccggccucuagugcagauc
uugguuggcguagcaaagaucuaacggagauauacucaacaugcaacguu
ggauacuggagcggggaaggauuucgugccaacggcacucguacacgagu
uguucggaaacugagcacaacguuauaucguuuuguuaggaaagugaagg
uggucggccauaacugaaaaggggcaacagagaaccugggauuauauucc
aaaaagaaauugcauguggg
......................<<<<<......<<....>>.......>>
>>.>.........<<....>>..<<<<<<......<<.....>>....>>
>>>>...<<<...<<<<<..<<<<<<<......>>>>>.>>....>>>>>
..........<<<<<<...<<<<<<<<.<<<<<......<<<......<<
<<.......>>>>.....<<........>>......>>>.<<.......(
(.....>>)).....>>>>>...>>>..>>>>>.>>>>>>..........
<<<<<<<........>>>>>>>.....<<<<<........>>>>>..>>>
....................................<<....>>......
..........<<<......>>>............................
......(((..<<<<<<.<<<<<<..((.<<<<.<<<<<<<<<...<<<<
...<<<<<<<<<........>>>>>>>>>.....>.>>>....>>>>>..
>>>>........<<<<<.....<<...<<<<.<<...>>...>>>>>>..
>>>>>.....<<<<...>>>>))..>>>>>>>>>>>>..))).<<<<...
.....>>>><<<<<<...<<<<<<<<.<<<<<..<<<.<<<<.<......
......>>>>>>>>...<<....>>..<<<<<.....>>>>>...<<<<<
...<<.<...>.>>....>>>>><<<<<<<<<.....>>>>>>.>>>...
>>>>>.>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<...
.<<<.<<<....>>>.>>>.....>>>...<<<<.<<.<<........>>
>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>.
.>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<.....<<...
<<<<<<<...<<<....<<<....<<<...<..>.>>>....>>>..>.>
>...>>>>>>>.....<<<<<<<<.<<.....>>>>>>>>>>........
...>>...>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>...<<
<<......>>>>..<<<<<<<...<<<(((......<..<<<<.......
.<.........<<<.<<<<<<<<<..>>>>>>>>>>>>..........))
).>....>>>>.>.........>>>...>>>>>>>((((.<<<<<.....
.....>>>>.........>>>>>))))....>>>>>....<<<<<<<<..
.......<<<..<<<....>>>.>>>.......>>>>>>>>........>
>>>>>..............<<<<<<<....................>>>>
>>>....................<<<<<....<<.....>>..>>>>>..
..<<..........<<.<<<<<......>>>>............<..<<.
<..........>.>>..>...>.>>..........<<<<.........>>
....>>.>>...........
Receptor-Ligand Complex Structure
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PDB6az3 Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		R88 H93 R94 L97 N102 N105 R106 K107 S109 R110 Q111 M112 R113 K120
Binding residue
(residue number reindexed from 1)		R87 H92 R93 L96 N101 N104 R105 K106 S108 R109 Q110 M111 R112 K119
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6az3, PDBe:6az3, PDBj:6az3
PDBsum6az3
PubMed29150609
UniProtE9BIP6

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